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Chemical Structure| 1201652-50-7 Chemical Structure| 1201652-50-7

Structure of Retro-2
CAS No.: 1201652-50-7

Chemical Structure| 1201652-50-7

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Retro-2 is a selective inhibitor of endosome-to-Golgi retrograde transport and a drug inhibiting Ebola virus (EBOV) infection, with an EC50 of 12.2 µM in HeLa cells. It can also induce autophagy.

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Product Details of Retro-2

CAS No. :1201652-50-7
Formula : C19H16N2OS
M.W : 320.41
SMILES Code : O=C(NC1=CC=CC=C1)C2=CC=CC=C2/N=C/C3=CC=C(C)S3
MDL No. :MFCD01042512
InChI Key :QEGJLRIARJEIPG-UHFFFAOYSA-N
Pubchem ID :727405

Safety of Retro-2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

Description
Retro-2 acts as a specific inhibitor, blocking retrograde protein transport at the interface between the endosome and the trans-Golgi network. It also serves as an inhibitor against ebolavirus (EBOV) infection, demonstrating an effective concentration (EC50) of 12.2 µM in HeLa cells. Furthermore, Retro-2 triggers autophagy in cells[1][2][3].

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3.12mL

0.62mL

0.31mL

15.61mL

3.12mL

1.56mL

31.21mL

6.24mL

3.12mL

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