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[ CAS No. 1201676-02-9 ] {[proInfo.proName]}

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Chemical Structure| 1201676-02-9
Chemical Structure| 1201676-02-9
Structure of 1201676-02-9 * Storage: {[proInfo.prStorage]}
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CAS No. :1201676-02-9 MDL No. :
Formula : C9H8BrCl2NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 312.98 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1201676-02-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1201676-02-9 ]
  • Downstream synthetic route of [ 1201676-02-9 ]

[ 1201676-02-9 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1201676-02-9 ]
  • [ 1201676-03-0 ]
YieldReaction ConditionsOperation in experiment
86% With ammonium hydroxide In tetrahydrofuran at 20℃; for 18 h; A mixture of 3-bromomethyl-2,6-dichloroisonicotinic acid ethyl ester (13.4 g, 42.7 mmol), tetrahydrofuran (100 ml_), and ammonium hydroxide (300 ml. of 28-30percent ammonia) is stirred at room temperature for 18 h. The solvents are then removed by rotary evaporation. The nearly dry solid is treated with a small amount of water. The salmon-colored solid is isolated by filtration, washed with small amounts of water and then diethyl ether, and dried under vacuum. Filtration of the cooled filtrate yields additional salmon-colored solid (7.47g, 36.8 mmol, 86percent). MS(ESI) m/z 203.2 (M+1 ). 1H NMR (400 MHz, DMSOd6) δ ppm 9.29 (br. s., 1 H), 7.83 (s, 1 H), 4.45 (s, 2 H).
Reference: [1] Patent: WO2009/150230, 2009, A1, . Location in patent: Page/Page column 180-181
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5422 - 5438
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