Structure of Ciforadenant
CAS No.: 1202402-40-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
CPI-444 is an orally administered antagonist of the adenosine A2A receptor. Upon oral administration, CPI-444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs).
Synonyms: CPI-444; V81444
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Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 1202402-40-1 |
Formula : | C20H21N7O3 |
M.W : | 407.43 |
SMILES Code : | NC1=NC(C2=CC=C(C)O2)=C(N=NN3CC4=NC(CO[C@@H]5COCC5)=CC=C4)C3=N1 |
Synonyms : |
CPI-444; V81444
|
MDL No. : | MFCD31540410 |
InChI Key : | KURQKNMKCGYWRJ-HNNXBMFYSA-N |
Pubchem ID : | 44537963 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
CD8+ T cells | 10 μM | 3 days | To evaluate the effect of Ciforadenant on reversing Spp1hi-TAM-mediated suppression of CD8+ T cell proliferation. Results showed that Ciforadenant significantly reduced the suppression of T cell proliferation by Spp1hi-TAMs. | PMC11779626 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
Mice | CRPC model | Oral gavage | 10 mg/kg | Once daily for 10 consecutive days | To evaluate the inhibitory effect of Ciforadenant on CRPC growth. Results showed that Ciforadenant significantly reduced CRPC growth and decreased the frequency and number of exhausted CD8+ T cells. | PMC11779626 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03708224 | Cancer Carcin... More >>oma Squamous Cell Carcinoma Head and Neck Cancer Less << | Phase 2 | Not yet recruiting | November 30, 2025 | United States, California ... More >> University of San Francisco, California San Francisco, California, United States, 94115 Less << |
NCT03337698 | Carcinoma, Non-Small-Cell Lung | Phase 1 Phase 2 | Recruiting | April 20, 2022 | United States, Connecticut ... More >> Smilow Cancer Hospital at Yale New Haven Recruiting New Haven, Connecticut, United States, 06510 United States, Massachusetts Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 United States, New York Columbia University Medical Center; Research Pharmacy, Irving Pavillion, Ip 7-749 Recruiting New York, New York, United States, 10032 United States, Tennessee Sarah Cannon Research Institute Recruiting Nashville, Tennessee, United States, 37203 Australia, Victoria Peter Mac Callum Cancer Center Recruiting East Melbourne, Victoria, Australia, 3002 France Centre Léon Bérard Recruiting Lyon, France, 69008 Hôpital Nord Not yet recruiting Marseille, France, 13915 Institut Universitaire du Cancer de Toulouse-Oncopole; PHARMACIE Recruiting Toulouse, France, 31100 Korea, Republic of Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 03080 Severance Hospital, Yonsei University Health System; Pharmacy Recruiting Seoul, Korea, Republic of, 03722 University of Ulsan College of Medicine - Asan Medical Center (AMC) - Asan Cancer Center (ACC) Recruiting Songpa-gu, Korea, Republic of, 05505 Spain Clínica Universidad de Navarra Recruiting Pamplona, Navarra, Spain, 31620 Hospital Universitari Vall d'Hebron Recruiting Barcelona, Spain, 08035 Fundación Jimenez Díaz Recruiting Madrid, Spain, 28040 South Texas Accelerated Research Therapeutics Madrid - CIOCC - Universitario Sanchinarro Recruiting Madrid, Spain, 28050 United Kingdom Barts Cancer Institute Recruiting London, United Kingdom, E1 2AT Royal Marsden Hospital; Institute of Cancer Research Recruiting Sutton, United Kingdom, SM2 5PT Less << |
NCT03454451 | Non-Small Cell Lung Cancer ... More >> Renal Cell Cancer Colorectal Cancer Triple Negative Breast Cancer Cervical Cancer Ovarian Cancer Pancreatic Cancer Endometrial Cancer Sarcoma Squamous Cell Carcinoma of the Head and Neck Bladder Cancer Metastatic Castration Resistant Prostate Cancer Less << | Phase 1 | Recruiting | December 2023 | United States, Connecticut ... More >> Yale School of Medicine Recruiting New Haven, Connecticut, United States, 06519 Contact: Site Coordinator 203-785-3482 ycci@yale.edu Principal Investigator: Patricia LoRusso, MD United States, Florida University of Miami Recruiting Miami, Florida, United States, 33136 Contact: Study Coordinator 305-243-0865 txl351@med.miami.edu Principal Investigator: Jaime Merchan, MD United States, Illinois The University of Chicago Recruiting Chicago, Illinois, United States, 60637 Contact: Site Coordinator 773-702-1835 mweist@medicine.bsd.uchicago.edu Principal Investigator: Jason Luke, MD United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Site Coordinator 212-824-7309 ccto@mssm.edu Principal Investigator: Thomas Marron, MD United States, North Carolina Carolina BioOncology Institute Recruiting Huntsville, North Carolina, United States, 28078 Contact: Study Coordinator 704-947-6599 info@carolinabiooncology.org Principal Investigator: John Powderly United States, Oklahoma University of Oklahoma - Stephenson Cancer Center Recruiting Oklahoma City, Oklahoma, United States, 73104 Contact: Site Coordinator 405-271-1112 SCC-Clinical-Trials-Office@ouhsc.edu Principal Investigator: Abhishek Tripathi, MD United States, Tennessee Sarah Cannon Research Institute Recruiting Nashville, Tennessee, United States, 37203 Contact: Site Coordinator 615-329-7274 asksarah@sarahcannon.com Principal Investigator: Melissa Johnson, MD United States, Texas Mary Crowley Cancer Research Recruiting Dallas, Texas, United States, 75230 Contact: Study Coordinator 972-566-3000 information@marycrowley.org Principal Investigator: Minal Barve, MD United States, Wisconsin Froedtert Hospital & Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Site Coordinator 414-805-8900 CCCTO@mcw.edu Principal Investigator: Matthew Riese, MD Less << |
NCT03237988 | Healthy Subjects | Phase 1 | Completed | - | United States, Texas ... More >> Covance Clinical Research Unit Dallas, Texas, United States, 75247 Less << |
NCT02655822 | Non-Small Cell Lung Cancer ... More >> Malignant Melanoma Renal Cell Cancer Triple Negative Breast Cancer Colorectal Cancer Bladder Cancer Metastatic Castration Resistant Prostate Cancer Less << | Phase 1 | Recruiting | October 2021 | - |
NCT02764892 | Parkinson's Disease | PHASE1 | COMPLETED | 2025-03-13 | - |
NCT01634568 | Parkinson's Disease | PHASE1 | COMPLETED | 2025-02-12 | Hammersmith Medicines Research... More >>, London, NW10 7EW, United Kingdom Less << |
Tags: Ciforadenant | CPI-444 | V81444 | CPI444 | CPI 444 | V81444 | V 81444 | V-81444 | Adenosine Receptor | P1 receptor | 1202402-40-1
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P222 | Do not allow contact with air. |
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P230 | Keep wetted |
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P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
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P240 | Ground/bond container and receiving equipment. |
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P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
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P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
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Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
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P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
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P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
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P321 | |
P322 | |
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P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
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P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
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P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
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P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
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P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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