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Chemical Structure| 120685-11-2 Chemical Structure| 120685-11-2

Structure of Midostaurin
CAS No.: 120685-11-2

Chemical Structure| 120685-11-2

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Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor that inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDGFRβ, and VEGFR1/2 with IC50s ranging from 22 to 500 nM. It also upregulates endothelial nitric oxide synthase (eNOS) gene expression and exhibits powerful anticancer effects.

Synonyms: PKC412; CGP 41251; Rydapt

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Product Details of Midostaurin

CAS No. :120685-11-2
Formula : C35H30N4O4
M.W : 570.64
SMILES Code : O=C(N([C@H]1[C@@H](OC)[C@@](O2)(C)N3C4=CC=CC=C4C5=C3C6=C(C7=CC=CC=C7N6[C@@]2([H])C1)C8=C5CNC8=O)C)C9=CC=CC=C9
Synonyms :
PKC412; CGP 41251; Rydapt
MDL No. :MFCD00871372

Safety of Midostaurin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Midostaurin

epigenetics
GPCR

Isoform Comparison

Biological Activity

Target
  • PKCη

    PKCη, IC50:160 nM

  • PKCβ

    PKCβ2, IC50:31 nM

    PKCβ1, IC50:30 nM

  • PKCγ

    PKCγ, IC50:24 nM

  • PKCε

    PKCε, IC50:1.25 μM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03951961 Acute Myeloid Leukemia, Adult PHASE2 TERMINATED 2021-02-28 Klinikum Chemnitz gGmbH, Chemn... More >>itz, 09113, Germany|Universit?tsklinikum Carl Gustav Carus an der Technischen Universit?t Dresden, Dresden, 01307, Germany|Universit?tsklinikum Jena, Jena, 07747, Germany|Universit?tsklinikum Leipzig A?R, Leipzig, 04103, Germany Less <<
NCT00233454 Systemic Mastocytosis, Aggress... More >>ive (ASM)|Leukemia, Mast Cell|Hematological Non-mast Cell Lineage Disease (AHNMD) Less << PHASE2 COMPLETED 2011-04-16 Stanford University School of ... More >>Medicine, Stanford, California, 94305, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States|Washington University-St. Louis, Saint Louis, Missouri, 63110, United States Less <<
NCT03114228 FLT3-mutated Acute Myeloid Leu... More >>kemia Less << NO_LONGER_AVAILABLE - Novartis Investigative Site, H... More >>amilton, Ontario, L8V 1C3, Canada|Novartis Investigative Site, Montreal, Quebec, H1T 2M4, Canada Less <<
NCT02723435 Acute Myeloid Leukemia With Ge... More >>ne Mutations|Adult Acute Myeloid Leukemia in Remission Less << PHASE2 WITHDRAWN 2025-04-18 -
NCT05488613 Acute Myeloid Leukemia (AML) COMPLETED 2021-01-26 Novartis Investigative Site, H... More >>elsinki, Finland Less <<
NCT01282502 Adenocarcinoma of the Rectum PHASE1 COMPLETED 2025-12-18 Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States Less <<
NCT03686345 Core Binding Factor Acute Myel... More >>oid Leukemia (CBF-AML) Less << PHASE2 RECRUITING 2025-12-31 Ospedale Cà Granda - Niguarda ... More >>S.C: Ematologia, Milano, 20162, Italy Less <<
NCT02624570 Acute Myeloid Leukemia (AML) W... More >>ith|FLT3 Mutation, Internal Tandem Duplication (ITD) or Tyrosine Kinase Domain (TKD) Less << NO_LONGER_AVAILABLE - Mayo Clinic Arizona, Phoenix, ... More >>Arizona, 85054, United States|The Jordan Research and Education Center ABSMC Comprehensive Cancer Ctr, Berkeley, California, 94705, United States|City of Hope National Medical Center Department of Hematology & HCT, Duarte, California, 91010, United States|St. Judes Medical Center, Fullerton, California, 92835, United States|University of Calif Irvine Medical Center Family Comp Cancer Cntr, Orange, California, 92868, United States|Kaiser Permanente Northwest Kaiser, Denver, Colorado, 80209, United States|Poudre Valley Hospital Poudre Valley Hospital -U of C, Fort Collins, Colorado, 80528, United States|Memorial Healthcare System Memorial Healthcare System, Hollywood, Florida, 33021, United States|UF Health Cancer Center at Orlando Health Orlando Health, Orlando, Florida, 32806, United States|H Lee Moffitt Cancer Center and Research Institute SC - 5, Tampa, Florida, 33612, United States|Augusta University Georgia Cancer Center Pharmacy, Augusta, Georgia, 30912, United States|Rush University Medical Center Dept.of Rush UniversityMedCtr., Chicago, Illinois, 60612, United States|University of Chicago Medical Center, Chicago, Illinois, 60637, United States|Indiana Blood and Marrow Institute Indiana Blood and Marrow Trans, Beech Grove, Indiana, 46107, United States|Ft Wayne Medical Oncology and Hematology Inc, Fort Wayne, Indiana, 46815, United States|Norton Cancer Institute Norton Cancer Institute, Louisville, Kentucky, 40202, United States|University of Louisville / James Graham Brown Cancer Center Louisville 529-539, Louisville, Kentucky, 40202, United States|Tulane University Medical Center, New Orleans, Louisiana, 70112, United States|Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States|Tufts Medical Center, Boston, Massachusetts, 02111, United States|Karmanos Cancer Institute Harper Hosp. Invest. Pharmacy, Detroit, Michigan, 48201, United States|Henry Ford Hospital SC, Detroit, Michigan, 48202-2689, United States|Mayo Clinic Mayo Clinic, Rochester, Minnesota, 55905, United States|Nebraska Cancer Specialist/Missouri Valley Cancer Consortium, Omaha, Nebraska, 68106, United States|Healthcare Partners Medical Group, Las Vegas, Nevada, 89109, United States|Weill Cornell Medical College NY Presbyterian Hospital, New York, New York, 10021, United States|University of Rochester Medical Center Univ of Rochester (7), Rochester, New York, 14642, United States|Kaiser Permanente NW Region Kaiser Permanente Northwest, Clackamas, Oregon, 97015, United States|Penn State University / Milton S. Hershey Medical Center Penn State Cancer Institute, Hershey, Pennsylvania, 17033-085, United States|University of Pennsylvania Cancer Center University of Pen/Abr Canc ctr, Philadelphia, Pennsylvania, 19104 4283, United States|Medical University of South Carolina Hematology-Oncology Division, Charleston, South Carolina, 29425, United States|Erlanger Medical Center Erlanger Health System, Chattanooga, Tennessee, 37403, United States|Vanderbilt University Medical Center, Clinical Trials Center Division Hematology/Oncology, Nashville, Tennessee, 37212, United States|University of Texas Medical Branch University of Texas MB, Galveston, Texas, 77555-1188, United States|McGovern Medical School at the University of Texas Health, Houston, Texas, 77004, United States|Oncology Consultants Oncology Consultants, Houston, Texas, 77024, United States|Methodist Healthcare System, San Antonio, Texas, 78229, United States|Intermountain Healthcare - Huntsman Cancer Clinics Intermountain Healthcare (2), Murray, Utah, 84107, United States|Huntsman Cancer Institute Univ of Utah, Salt Lake City, Utah, 84112 0550, United States|Virginia Oncology Associates Virginia Oncology Assoc. (6), Norfolk, Virginia, 23502, United States|Swedish Cancer Institute Cancer Institute, Seattle, Washington, 98104, United States|Veterans Affairs Puget Sound Health Care System VAMC Seattle, WA Divison, Seattle, Washington, 98108, United States|Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, 98801, United States|Cheyenne Regional Medical Center, Cheyenne, Wyoming, 82001, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.75mL

0.35mL

0.18mL

8.76mL

1.75mL

0.88mL

17.52mL

3.50mL

1.75mL

References

 

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