[ CAS No. 121058-88-6 ] {[proInfo.proName]}

Name: 121058-88-6|Ac-rC Phosphoramidite|95%
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Quality Control of [ 121058-88-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 121058-88-6 ]

Product Details of [ 121058-88-6 ]

CAS No. :	121058-88-6	MDL No. :	MFCD09842111
Formula :	C₄₇H₆₄N₅O₉PSi	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	902.10	Pubchem ID :	-
Synonyms :

Safety of [ 121058-88-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 121058-88-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 121058-88-6 ]
Downstream synthetic route of [ 121058-88-6 ]

[ 121058-88-6 ] Synthesis Path-Upstream 1~8

1
[ 124482-92-4 ]
[ 121058-85-3 ]
[ 121058-88-6 ]

Reference： [1] Tetrahedron Letters, 1995, vol. 36, # 49, p. 8929 - 8932
[2] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74

2
[ 102691-36-1 ]
[ 121058-85-3 ]
[ 121058-88-6 ]

Reference： [1] Chemical Communications, 2014, vol. 50, # 56, p. 7463 - 7465

3
[ 40615-36-9 ]
[ 121058-88-6 ]

Reference： [1] Tetrahedron Letters, 1995, vol. 36, # 49, p. 8929 - 8932
[2] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74

4
[ 121058-82-0 ]
[ 121058-88-6 ]

Reference： [1] Tetrahedron Letters, 1995, vol. 36, # 49, p. 8929 - 8932
[2] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74

5
[ 18162-48-6 ]
[ 121058-88-6 ]

Reference： [1] Tetrahedron Letters, 1995, vol. 36, # 49, p. 8929 - 8932
[2] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74

6
[ 3768-18-1 ]
[ 121058-88-6 ]

Reference： [1] Tetrahedron Letters, 1995, vol. 36, # 49, p. 8929 - 8932
[2] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74

7
[ 51432-41-8 ]
[ 121058-88-6 ]

Reference： [1] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74

8
[ 65-46-3 ]
[ 121058-88-6 ]

Reference： [1] Tetrahedron Letters, 1989, vol. 30, # 1, p. 71 - 74

[ 121058-88-6 ] Synthesis Path-Downstream 1~44

1
[ 124482-92-4 ]
[ 121058-85-3 ]
[ 121058-88-6 ]

Reference： [1]Tetrahedron Letters,1995,vol. 36,p. 8929 - 8932
[2]Tetrahedron Letters,1989,vol. 30,p. 71 - 74

2
[ 121058-88-6 ]
C₄₁H₅₁N₄O₁₀PSi [ No CAS ]

Reference： [1]Tetrahedron Letters,1999,vol. 40,p. 8971 - 8974
[2]Journal of the American Chemical Society,2017,vol. 139,p. 16154 - 16160

3
[ 121058-88-6 ]
[ 121058-85-3 ]

Reference： [1]Tetrahedron Letters,1999,vol. 40,p. 8971 - 8974

4
[ 40615-36-9 ]
[ 121058-88-6 ]

Reference： [1]Tetrahedron Letters,1995,vol. 36,p. 8929 - 8932
[2]Tetrahedron Letters,1989,vol. 30,p. 71 - 74

5
[ 121058-82-0 ]
[ 121058-88-6 ]

Reference： [1]Tetrahedron Letters,1995,vol. 36,p. 8929 - 8932
[2]Tetrahedron Letters,1989,vol. 30,p. 71 - 74

6
[ 18162-48-6 ]
[ 121058-88-6 ]

Reference： [1]Tetrahedron Letters,1995,vol. 36,p. 8929 - 8932
[2]Tetrahedron Letters,1989,vol. 30,p. 71 - 74

7
[ 3768-18-1 ]
[ 121058-88-6 ]

Reference： [1]Tetrahedron Letters,1995,vol. 36,p. 8929 - 8932
[2]Tetrahedron Letters,1989,vol. 30,p. 71 - 74

8
[ 51432-41-8 ]
[ 121058-88-6 ]

Reference： [1]Tetrahedron Letters,1989,vol. 30,p. 71 - 74

9
[ 65-46-3 ]
[ 121058-88-6 ]

Reference： [1]Tetrahedron Letters,1989,vol. 30,p. 71 - 74

Yield	Reaction Conditions	Operation in experiment
83%		5'-O-Dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N4-acetylcytidine 3'-N,N-diisopropyl(cyanoethyl)phosphoramidite (48) Compound (48) was obtained as an off white foam via the standard phosphitylation procedure (as described for compound 9 in example 1) using-2-cyanoethyl-N,N-diisopropylchlorophosphoramidite (2.5 eq), N,N-diisopropylethylamine (4 eq) and 1-methylimidazole (0.5 eq). Yield 83%.
83%		5'-O-Dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N4-acetylcytidine 3'-N,N-diisopropyl(cyanoethyl)phosphoramidite (48) Compound (48) was obtained as an off white foam via the standard phosphitylation procedure (as described for compound 9 in example 1) using -2-cyanoethyl-N,N-diisopropylchlorophosphoramidite (2.5 eq), N,N-diisopropylethylamine (4 eq) and 1-methylimidazole (0.5 eq). Yield 83%.

Yield	Reaction Conditions	Operation in experiment
84%		5'-O-Dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N4-acetylcytidine 3'-N,N-diisopropyl(cyanoethyl)phosphoramidite (43) Compound (43) was obtained as white foam via the standard phosphitylation procedure (as described for compound 9 in example 1) using 2-cyanoethyl-N,N-diisopropylchlorophosphoramidite (2.5 eq), N,N-diisopropylethylamine (4 eq) and 1-methylimidazole (0.5 eq). Yield 84%.

Yield	Reaction Conditions	Operation in experiment
84%		5'-O-Dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N4-acetylcytidine 3'-N,N-diisoproply(cyanoethyl)phosphoramidite (43) Compound (43) was obtained as white foam via the standard phosphitylation procedure (as described for compound 9 in example 1) using 2-cyanoethyl-N,N-diisopropylchlorophosphoramidite (2.5 eq), N,N-diisopropylethylamine (4 eq) and 1-methylimidazole (0.5 eq). Yield 84%.

13
[ 121058-88-6 ]
[ 897626-57-2 ]

Reference： [1]Organic Letters,2008,vol. 10,p. 2793 - 2796

14
[ 922522-12-1 ]
[ 7144-08-3 ]
[ 98796-51-1 ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
[ 147201-04-5 ]
5'-[6-[[2-((cholesteryl-3-yl)oxycarbonyl)aminoethoxy]carbonyl]aminohexyl]-r(UCGUCCAUGUGGUCAUGGC)TT-3' [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2144 - 2147

15
[ 1146731-42-1 ]
[ 121058-88-6 ]
[ 1174673-48-3 ]

Reference： [1]Chemistry - A European Journal,2009,vol. 15,p. 6244 - 6257

16
[ 944138-03-8 ]
[ 1196511-54-2 ]
C₃₈H₄₆N₃O₈PolSi [ No CAS ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
5'-[{5'-[3-hydroxymethyl-5-(naphth-1-yl)phenyl]methyloxy}C]CCAGUGUUCAGACUACCUGUUC-3' [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 7299 - 7302

17
[ 944138-03-8 ]
[ 1196511-54-2 ]
C₄₄H₄₈N₅O₇PolSi [ No CAS ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
3'-AUUGGUUACACGUCUGAUGAC[5'-[3-hydroxymethyl-5-(naphth-1-yl)phenyl]methyloxy}A]-5' [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 7299 - 7302

18
[ 944138-03-8 ]
C₃₈H₄₆N₃O₈PolSi [ No CAS ]
[ 1261237-72-2 ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
5'-[{5'-{3-hydroxymethyl-5-[4-(dimethylamino)naphth-1-yl]phenyl}methyloxy}C]CCAGUGUGCAGACUACUGUUC-3' [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 7299 - 7302

19
[ 944138-03-8 ]
C₃₈H₄₆N₃O₈PolSi [ No CAS ]
[ 1261237-72-2 ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
5'-[{5'-{3-hydroxymethyl-5-[4-(dimethylamino)naphth-1-yl]phenyl}methyloxy}C]CCAGUGUUCAGACUACCUGUUC-3' [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 7299 - 7302

20
[ 944138-03-8 ]
[ 1261237-72-2 ]
C₄₄H₄₈N₅O₇PolSi [ No CAS ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
3'-AUUGGUUACAAGUCUGAUGGAC[5'-{{3-hydroxymethyl-5-[4-(dimethylamino)naphth-1-yl]phenyl}methyloxy}A]-5' [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 7299 - 7302

21
[ 944138-03-8 ]
[ 1261237-72-2 ]
C₄₄H₄₈N₅O₇PolSi [ No CAS ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
3'-AUUGGUUACACGUCUGAUGAC[5'-{{3-hydroxymethyl-5-[4-(dimethylamino)naphth-1-yl]phenyl}methyloxy}A]-5' [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 7299 - 7302

22
[ 944138-03-8 ]
C₂₃H₃₀N₅O₅PolSi [ No CAS ]
[ 1227873-20-2 ]
[ 121058-88-6 ]
[ 144490-31-3 ]
[ 104992-55-4 ]
5'-CUUAC-[OCH₂(S)CH(NHCOC₆H₄-4-NN-Ph)(S)CHMeOPO₃]-ACUGA-3' [ No CAS ]