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[ CAS No. 1211586-14-9 ] {[proInfo.proName]}

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Product Details of [ 1211586-14-9 ]

CAS No. :1211586-14-9 MDL No. :MFCD18382710
Formula : C12H22N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :XEDSJRNOTLOESP-UHFFFAOYSA-N
M.W : 226.32 Pubchem ID :66823462
Synonyms :

Safety of [ 1211586-14-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1211586-14-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1211586-14-9 ]

[ 1211586-14-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 24424-99-5 ]
  • [ 1211586-14-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine; dmap / dichloromethane / 20 °C 2: hydrogen; acetic acid; platinum(IV) oxide / 24 h / 50 °C / 30003 Torr
  • 2
  • [ 272-49-1 ]
  • [ 1211586-14-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: triethylamine; dmap / dichloromethane / 20 °C 2: hydrogen; acetic acid; platinum(IV) oxide / 24 h / 50 °C / 30003 Torr
  • 3
  • [ 1018950-15-6 ]
  • tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With platinum(IV) oxide; hydrogen; acetic acid at 50℃; for 24h; 6.2 To a solution of tert-butyl 1H-pyrrolo[3,2-b]pyridine-1-carboxylate 6b (1.00 g, 4.59 mmol) in 30 mL acetic acid was added PtO2 (104 mg, 0.460 mmol), the resulting mixture was stirred under H2 (4 MPa) atmosphere at 50° C. for 24 h. The reaction mixture was cooled to room temperature, filtered, and concentrated under reduced pressure to give crude tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate 6c (1.0 g, colorless oil, 96%) which was used in the next step without further purification. MS-ESI calc'd. [M+H]+ 227, found 227.
  • 4
  • [ 1211586-14-9 ]
  • [ 501-53-1 ]
  • [ 1821236-82-1 ]
YieldReaction ConditionsOperation in experiment
1.35 g With N-ethyl-N,N-diisopropylamine at 0 - 20℃; Inert atmosphere; 6.3 To a solution of tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate 6c (1.00 g, 4.42 mmol) in 30 mL dichloromethane was added N,N-diisopropylethylamine (2.4 mL, 13.3 mmol) and Carboxylic acid chloride benzyl ester (1.13 g, 6.63 mmol) at 0° C. under N2 atmosphere. The resulting mixture was stirred at room temperature overnight, then was concentrated under reduced pressure. The residue was added 20 mL water, the aqueous mixture was extracted with EtOAc (30 mL*3). The combined organic layers were washed with brine (30 mL), dried over anhydrous Na2SO4, filtered, and concentrated to give crude product which was purified by silica gel column chromatography (10% EtOAc/PE) to give 4-benzyl 1-tert-butyl hexahydro-1H-pyrrolo[3,2-b]pyridine-1,4(2H)-dicarboxylate 6d (1.35 g, yellow oil, yield: 85%). MS-ESI calc'd. [M+H]+ 361, found 361.
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