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[ CAS No. 122733-39-5 ] {[proInfo.proName]}

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Chemical Structure| 122733-39-5
Chemical Structure| 122733-39-5
Structure of 122733-39-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 122733-39-5 ]

CAS No. :122733-39-5 MDL No. :MFCD00085131
Formula : C9H7N3O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :205.17 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 122733-39-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 122733-39-5 ]

[ 122733-39-5 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 7439-89-6 ]
  • [ 122733-39-5 ]
  • [ 122733-40-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; potassium hydroxide In ethanol; dichloromethane 5 5-(2,5-Dimethylphenoxy)-2,2-dimethyl-N-[3-(5-methyl1,3,4-oxadiazol-2-yl)phenyl]pentanamide Iron powder, 27.9 g (0.5 mol), is added to a mixture of 2-methyl-5-(3-nitrophenyl)-1,3,4-oxadiazole, (0.053 mol), in 1000 ml of ethyl alcohol with stirring. The mixture is heated to reflux and 1.73 ml of concentrated hydrochloric acid in 10 ml of ethyl alcohol is added dropwise. The mixture is reluxed three hours, 20 ml of 1 normal potassium hydroxide is added, the mixture filtered, and the filtrate evaporated. The residue is dissolved in dichloromethane, washed with water, and the methylene chloride layer separated and evaporated to give 7.05 g of 3-(5-methyl-1,3,4-oxadiazol-2-yl) benzenamine after recrystallization from 2-propanol; mp 139°-140° C.
  • 2
  • [ 122733-39-5 ]
  • [ 122733-40-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogen In ethyl acetate for 4h; 84 340 mg of 2-Methyl-5-(3-nitro-phenyl)-[1 ,3,4]oxadiazole and 5 mg of palladium on charcoal (10%) in 30 ml of EtOAc are flushed with hydrogen gas and stirred under an atmosphere of hydrogen for4 hours. The mixture obtained is filtered through celite and the filtrate obtained is concentrated.3-(5-Methyl-[1 ,3,4]oxadiazol-2-yl)-phenylamine is obtained.
  • 3
  • [ 1445-45-0 ]
  • [ 618-94-0 ]
  • [ 122733-39-5 ]
YieldReaction ConditionsOperation in experiment
93% With Al3+-K10 montmorillonite clay; In neat (no solvent); at 55℃; for 0.25h;Microwave irradiation; General procedure: A 5 mL microwave vial was charged with acidhydrazide (100 mg, 1 eq), trimethyl orthoester (2 eq) and Al3+-K10 clay (75 mg). The resulting mixture was kept under microwave irradiation maintaining the temperature at 55 C for 15 min (Microwave irradiations were performed on CEM-discover model No. 908010). The reaction was monitored by TLC. After completion of the reaction, reaction mixture was diluted with ethyl acetate stirred well, filtered, washed well with ethyl acetate. Filtrate was evaporated under reduced pressure to obtain highly pure product. In some cases, products were purified by column chromatography using 60-120 mesh silica with 20-100 % ethyl acetate in pet ether as eluting solvents. The catalyst recovered by filtration was reused for another 5 more times.
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