[ CAS No. 123495-48-7 ] {[proInfo.proName]}

Name: 123495-48-7|(S)-Ethyl piperidine-2-carboxylate hydrochloride|97%
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Quality Control of [ 123495-48-7 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 123495-48-7 ]

Product Details of [ 123495-48-7 ]

CAS No. :	123495-48-7	MDL No. :	MFCD09264372
Formula :	C₈H₁₆ClNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	KGAWPIXNSIYQPC-FJXQXJEOSA-N
M.W :	193.67	Pubchem ID :	49802334
Synonyms :

Calculated chemistry of [ 123495-48-7 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.88
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	53.42
TPSA :	38.33 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.44 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.0
Log Po/w (XLOGP3) :	1.46
Log Po/w (WLOGP) :	1.11
Log Po/w (MLOGP) :	1.0
Log Po/w (SILICOS-IT) :	1.22
Consensus Log Po/w :	0.96

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.76
Solubility :	3.35 mg/ml ; 0.0173 mol/l
Class :	Very soluble
Log S (Ali) :	-1.87
Solubility :	2.61 mg/ml ; 0.0135 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.56
Solubility :	5.37 mg/ml ; 0.0277 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.22

Safety of [ 123495-48-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 123495-48-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 123495-48-7 ]
Downstream synthetic route of [ 123495-48-7 ]

[ 123495-48-7 ] Synthesis Path-Upstream 1~3

1
[ 1258422-24-0 ]
[ 123495-48-7 ]

Reference： [1] Russian Journal of Organic Chemistry, 2010, vol. 46, # 9, p. 1277 - 1281
[2] Tetrahedron Asymmetry, 2017, vol. 28, # 2, p. 349 - 354

2
[ 64-17-5 ]
[ 3105-95-1 ]
[ 123495-48-7 ]

Reference： [1] Tetrahedron Letters, 2006, vol. 47, # 29, p. 5017 - 5020
[2] Patent: EP931078, 2006, B1, . Location in patent: Page/Page column 33

3
[ 1258422-16-0 ]
[ 123495-48-7 ]

Reference： [1] Tetrahedron Asymmetry, 2017, vol. 28, # 2, p. 349 - 354

[ 123495-48-7 ] Synthesis Path-Downstream 1~18

1
[ 78553-60-3 ]
[ 123495-48-7 ]
[ 123495-49-8 ]

Reference： [1]Zeitschrift fur Chemie,1989,vol. 29,p. 20 - 21

2
[ 2969-81-5 ]
[ 123495-48-7 ]
(S)-1-(3-Ethoxycarbonyl-propyl)-piperidine-2-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 5017 - 5020

3
[ 64-17-5 ]
[ 3105-95-1 ]
[ 123495-48-7 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; for 0.333333h;Heating / reflux;	L-Pipecolinic acid (0.9g, 6.97 mmol) is dissolved in 40 mL of absolute EtOH. HCl gas is bubbled for -1 minute. The reaction mixture is refluxed for 20 min, cooled and the solvents removed by rotary evaporation to give 1.34g of the title compound, a wax that is used without further purification.

Reference： [1]Tetrahedron Letters,2006,vol. 47,p. 5017 - 5020
[2]Patent: EP931078,2006,B1 .Location in patent: Page/Page column 33

4
[ 123495-48-7 ]
[ 123495-50-1 ]

Reference： [1]Zeitschrift fur Chemie,1989,vol. 29,p. 20 - 21

5
[ 123495-48-7 ]
[ 117659-74-2 ]

Reference： [1]Zeitschrift fur Chemie,1989,vol. 29,p. 20 - 21

6
[ 123495-48-7 ]
[ 123518-90-1 ]

Reference： [1]Zeitschrift fur Chemie,1989,vol. 29,p. 20 - 21

7
[ 2991-42-6 ]
[ 123495-48-7 ]
(2S)-1-(4-trifluoromethyl-benzenesulfonyl)-piperidine-2-carboxylic acid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40%	With triethylamine; In dichloromethane; at 20℃; for 15.0h;	To a solution of (2S)-ethyl-2-piperidinecarboxylate hydrochloride (0.200g, 1. 03mmol) (ref : PCT hit. Appl. (2002), W00200653) in dichloromethane (lOmL) was added 4-trifluoromethylbenzenesulphonyl chloride (0.240g, 0. 98mmol) followed by triethylainine (0.29mL, 2. 06mmol) and the reaction mixture was stirred at room temperature for 15h. The mixture was diluted with dichloromethane and washed with saturated aqueous sodium bicarbonate followed by brine. The organic layer was dried over MgS04. The MgS04 was removed by filtration and the filtrate evaporated to afford (2-ethyl-1- (4-trifluoromethylbenzenesulphonyl) piperidine-2-carboxylate as a colourless oil (0.152g, 40%). HPLC (Method A) retention time 4. 32min (Solvent: MeCN/H20/0.05% HCOzH, 5-95% gradient H20-6 min. Column : Waters Xterra 50 x 4.60 mm i. d., C18 reverse phase. Flow rate: 1.5 mL/min. ). Mass spectrum (ES+) m/z 366 (M+H).

Reference： [1]Patent: WO2005/68448,2005,A1 .Location in patent: Page/Page column 47

8
[ 3436-04-2 ]
[ 123495-48-7 ]
[ 3105-95-1 ]
(S)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-2-piperidinecarboxylicacid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
2.3 g (69%)	With thionyl chloride; potassium iodide; potassium carbonate; In diethyl ether; ethanol; n-heptane; water; ethyl acetate; butanone;	Example 27 (S)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-2-piperidinecarboxylic acid hydrochloride STR30 Crude (S)-(-)-2-piperidinecarboxylic acid (19.5 g, prepared as described in example 26) was suspended in ethanol (250 ml), and thionyl chloride (40 ml, 0.46 mol) was added dropwise. After addition was complete, the suspension was heated at reflux temperature for 2 h. The mixture was filtered hot, and the filtrate was cooled to room temperature. Filtration and evaporation in vacuo afforded an oil, which was crystallized by rubbing. Ethanol (10 ml) was added, followed by slow addition of diethyl ether (150 ml). The precipitated solid was filtered off, washed with diethyl ether and dried by suction to give 13.8 g (35% calculated from 2-piperidinecarboxylic acid) <strong>[123495-48-7](S)-(-)-2-piperidinecarboxylic acid ethyl ester hydrochloride</strong>. [alpha]25D =-10.7 (c=4.5% in water) Gas Chromatography (run as described in example 26) of N-acetyl derivative: Rt =47.2 minutes. Enantiomeric excess=96%. 5-(3-Bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2.7 g, 8.6 mmol, prepared as described in WO 9518793), potassium carbonate (7.14 g, 52 mmol), potassium iodide (1.4 g, 8.6 mmol), and <strong>[123495-48-7](S)-(-)-2-piperidinecarboxylic acid ethyl ester hydrochloride</strong> (3.3 g, 17 mmol) were mixed in methyl ethyl ketone (50 ml) and heated at reflux temperature for 3 days. After cooling to room temperature, ethyl acetate (100 ml) was added and the mixture was washed with water (2*100 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by column chromatography on silica gel (600 ml), using a mixture of ethyl acetate and heptane (1:4) as eluent. This afforded 2.3 g (69%) of (S)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-2-piperidinecarboxylicacid ethyl ester as an oil. TLC: Rf =0.22 (SiO2: ethyl acetate/heptane=1:4)
2.3 g (69%)	With thionyl chloride; potassium iodide; potassium carbonate; In diethyl ether; ethanol; n-heptane; water; ethyl acetate; butanone;	Example 27 (S)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-2-piperidinecarboxylic acid hydrochloride Crude (S)-(-)-2-piperidinecarboxylic acid (19.5 g, prepared as described in example 26) was suspended in ethanol (250 ml), and thionyl chloride (40 ml, 0.46 mol) was added dropwise. After addition was complete, the suspension was heated at reflux temperature for 2 h. The mixture was filtered hot, and the filtrate was cooled to room temperature. Filtration and evaporation in vacuo afforded an oil, which was crystallized by rubbing. Ethanol (10 ml) was added, followed by slow addition of diethyl ether (150 ml). The precipitated solid was filtered off, washed with diethyl ether and dried by suction to give 13.8 g (35% calculated from 2-piperidinecarboxylic acid) <strong>[123495-48-7](S)-(-)-2-piperidinecarboxylic acid ethyl ester hydrochloride</strong>. [alpha]25D=-10.7 (c=4.5% in water) Gas Chromatography (run as described in example 26) of N-acetyl derivative: Rt=47.2 minutes. Enantiomeric excess=96% 5-(3-Bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2.7 g, 8.6 mmol, prepared as described in WO 9518793), potassium carbonate (7.14 g, 52 mmol), potassium iodide (1.4 g,8.6 mmol), and <strong>[123495-48-7](S)-(-)-2-piperidinecarboxylic acid ethyl ester hydrochloride</strong> (3.3 g, 17 mmol) were mixed in methyl ethyl ketone (50 ml) and heated at reflux temperature for 3 days. After cooling to room temperature, ethyl acetate (100 ml) was added and the mixture was washed with water (2*100 ml), dried. (MgSO4) and evaporated in vacuo. The residue was purified by column chromatography on silica gel (600 ml), using a mixture of ethyl acetate and heptane (1:4) as eluent. This afforded 2.3 g (69%) of (S)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-2-piperidinecarboxylicacid ethyl ester as an oil. TLC: Rf=0.22 (SiO2: ethyl acetate/heptane=1:4)

Reference： [1]Patent: US6110913,2000,A
[2]Patent: US6239148,2001,B1

9
[ 3436-04-2 ]
[ 123495-48-7 ]
[ 3105-95-1 ]
[ 183786-22-3 ]

Yield	Reaction Conditions	Operation in experiment
2.3 g (69%)	With thionyl chloride; potassium iodide; potassium carbonate; In diethyl ether; ethanol; n-heptane; water; ethyl acetate; butanone;	STR30 Crude (S)-(-)-2-piperidinecarboxylic acid (19.5 g, prepared as described in example 26) was suspended in ethanol (250 ml), and thionyl chloride (40 ml, 0.46 mol) was added dropwise. After addition was complete, the suspension was heated at reflux temperature for 2 h. The mixture was filtered hot, and the filtrate was cooled to room temperature. Filtration and evaporation in vacuo afforded an oil, which was crystallized by rubbing. Ethanol (10 ml) was added, followed by slow addition of diethyl ether (150 ml). The precipitated solid was filtered off, washed with diethyl ether and dried by suction to give 13.8 g (35% calculated from 2-piperidinecarboxylic acid) <strong>[123495-48-7](S)-(-)-2-piperidinecarboxylic acid ethyl ester hydrochloride</strong>. [alpha]25D =-10.7 (c=4.5% in water) Gas Chromatography (run as described in example 26) of N-acetyl derivative: Rt =47.2 minutes. Enantiomeric excess=96%. 5-(3-Bromo-1-propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene (2.7 g, 8.6 mmol, prepared as described in WO 9518793), potassium carbonate (7.14 g, 52 mmol), potassium iodide (1.4 g, 8.6 mmol), and <strong>[123495-48-7](S)-(-)-2-piperidinecarboxylic acid ethyl ester hydrochloride</strong> (3.3 g, 17 mmol) were mixed in methyl ethyl ketone (50 ml) and heated at reflux temperature for 3 days. After cooling to room temperature, ethyl acetate (100 ml) was added and the mixture was washed with water (2*100 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by column chromatography on silica gel (600 ml), using a mixture of ethyl acetate and heptane (1:4) as eluent. This afforded 2.3 g (69%) of (S)-1-(3-(10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-1-propyl)-2-piperidinecarboxylicacid ethyl ester as an oil. TLC: Rf =0.22 (SiO2:ethyl acetate/heptane=1:4)

Reference： [1]Patent: US6071901,2000,A

10
[ 123495-48-7 ]
[ 183788-13-8 ]
[ 204574-58-3 ]
[ 204574-57-2 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dichloromethane; at 25℃; for 72.0h;	3-Bromo-8,11-dichloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (1.10 g, 3.00 mmol) and L-pipecolinic acid ethyl ester hydrochloride from Example 12, Step A1 (1.34 g, 6.98 mmol), triethylamine (2.91 muL, 21 mmol) are dissolved in dry CH2Cl2 (20ml) and the mixture is stirred at 25C under nitrogen for 72h. The reaction mixture is washed with saturated NaHCO3, H2O, brine and then filtered through Na2SO4 and evaporated to dryness. The product is chromatographed on a silica gel column using 1% ethyl acetate-dichloromethane as the eluant to separate the two separable diastereomeric isomers (i.e. Isomers A1 ester and B1 ester), the less polar being referred to as Isomer A1 ester and the more polar isomer being referred to as Isomer B1 ester. FABMS MH+ = 464.

Reference： [1]Patent: EP931078,2006,B1 .Location in patent: Page/Page column 34

11
[ 5781-53-3 ]
[ 123495-48-7 ]
ethyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-piperidinecarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20℃;	To a stirred solution of ethyl piperidine-2-carboxylate (7, 20.0 g, 103.3 mmol) in CH2Cl2 (30 mL) at 0 0C was added NJV-diisopropylethylamine (45.0 mL, 258.2 mmol) and methyl chlorooxoacetate (1 1.9 mL, 129.1 mmol). The reaction mixture was stirred at rt for 1.5 h, then diluted with CH2Cl2 (250 mL) and washed with water (300 mL) and brine (200 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (20% EtOAc in petroleum ether) to afford amide 8 (17.5 g, 69%) as a reddish oil: 1H NMR (CDCl3, 400 MHz, delta 5.00 (d , J= 5.2 Hz, IH), 4.13 (q, J= 14.4 Hz, 2H), 3.80 (s, 3H), 3.41 (br d, J= 13.2 Hz, IH), 3.20-3.17 (m, IH), 2.15 (br d, y= 14.4 Hz, IH), 1.69-1.61 (m, 4H), 1.39-1.27 (m, 4H).

Reference： [1]Patent: WO2010/77317,2010,A2 .Location in patent: Page/Page column 102; 103

12
[ 1258422-24-0 ]
[ 123495-48-7 ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: To a solution of compound (R,S)-12 (130 mg, 0.5 mmol) in 10 mlof methanol, 5 mol% of palladium on carbon (5% Pd) was added.Then a rubber ball filled with hydrogen was connected to the flaskand the mixture was stirred in the hydrogen atmosphere for 4 h atroom temperature. After the total disappearance of starting compound(TLC monitoring) the reaction mixture was filtered and3 M HCl was added to filtrate. Solvents were evaporated usingrotary evaporator. The residue was washed with ethyl acetateand dried in high vacuum for 30 min to afford white powder in a79 mg (80%) yield. Ethyl (R)-1-piperidine-2-carboxylatehydrochloride (R)-13: [a]D22 = +1.8 (c 0.2, H2O); 1H NMR (D2O) d:4.25 (q, J = 7.0 Hz, 2H); 4.00 (d, J = 12 Hz, 1H), 3.45 (d, J = 12 Hz,1H), 3.08 (d, J = 12 Hz, 1H), 2.50 (m, 1H), 1.8 (m,2H), 1.50-1.70(m, 3H),1.30 (t, J = 7.1 Hz, 3H); 13C NMR (D2O) d: 169.7, 63.5,56.9, 44.1, 25.6, 21.2, 13.2. Ethyl (S)-1-piperidine-2-carboxylatehydrochloride (S)-13: [a]D22 = 2.1 (c 0.15, H2O); 1H and 13C NMRspectra are identical to those of compound (R)-13.

Reference： [1]Russian Journal of Organic Chemistry,2010,vol. 46,p. 1277 - 1281
[2]Tetrahedron Asymmetry,2017,vol. 28,p. 349 - 354

13
[ 123495-48-7 ]
[ 3105-95-1 ]

Reference： [1]Russian Journal of Organic Chemistry,2010,vol. 46,p. 1277 - 1281

14
[ 123495-48-7 ]
[ 22328-78-5 ]

Reference： [1]Organometallics,2013,vol. 32,p. 1971 - 1978

15
[ 123495-48-7 ]
C₂₆H₁₅BF₁₅NO₂ [ No CAS ]

Reference： [1]Organometallics,2013,vol. 32,p. 1971 - 1978

16
[ 123495-48-7 ]
C₂₆H₁₅BF₁₅NO₂ [ No CAS ]

Reference： [1]Organometallics,2013,vol. 32,p. 1971 - 1978

17
(R)-N-[(S)-(1-phenylethyl)amino]pent-4-enoic acid ethyl ester [ No CAS ]
[ 123495-48-7 ]

Reference： [1]Tetrahedron Asymmetry,2017,vol. 28,p. 349 - 354

18
[ 1258422-16-0 ]
[ 123495-48-7 ]

Reference： [1]Tetrahedron Asymmetry,2017,vol. 28,p. 349 - 354

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P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 123495-48-7 ] {[proInfo.proName]}

Quality Control of [ 123495-48-7 ]

Related Doc. of [ 123495-48-7 ]

Product Details of [ 123495-48-7 ]

Calculated chemistry of [ 123495-48-7 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 123495-48-7 ]

Application In Synthesis of [ 123495-48-7 ]

[ 123495-48-7 ] Synthesis Path-Upstream 1~3

[ 123495-48-7 ] Synthesis Path-Downstream 1~18

Related Functional Groups of [ 123495-48-7 ]

Esters

Related Parent Nucleus of [ 123495-48-7 ]

Aliphatic Heterocycles

Piperidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 123495-48-7 ]

Related Parent Nucleus of
[ 123495-48-7 ]