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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1235397-05-3 Chemical Structure| 1235397-05-3

Structure of PF-04856264
CAS No.: 1235397-05-3

Chemical Structure| 1235397-05-3

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PARP1-IN-2 is a PARP1 inhibitor that can cross the blood-brain barrier with an IC50 of 149 nM, showing significant antiproliferative activity against the human lung adenocarcinoma cell line A549, inducing apoptosis and suitable for cancer research, especially in PARP-mediated DNA repair pathway studies.

4.5 *For Research Use Only !

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Product Details of PF-04856264

CAS No. :1235397-05-3
Formula : C20H15N5O3S2
M.W : 437.49
SMILES Code : O=S(C1=CC=C(OC2=CC=CC=C2C3=CC=NN3C)C(C#N)=C1)(NC4=NC=CS4)=O
MDL No. :MFCD28124397
InChI Key :MKSKJVIBSRUWSZ-UHFFFAOYSA-N
Pubchem ID :71718072

Safety of PF-04856264

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
PF-04856264 acts as a potent and selective Nav1.7 channel inhibitor, exhibiting IC50 values of 28 nM for humans, 131 nM for mice, 19 nM for cynomolgus monkeys, and 42 nM for dogs. Its efficacy against rat Nav1.7 channels is comparatively low. PF-04856264 demonstrates analgesic properties[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.43mL

2.29mL

1.14mL

22.86mL

4.57mL

2.29mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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