Alternatived Products of [ 1239576-61-4 ]
Product Details of [ 1239576-61-4 ]
CAS No. : | 1239576-61-4 |
MDL No. : | |
Formula : |
C14H19F2NO3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
287.30
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1239576-61-4 ]
Application In Synthesis of [ 1239576-61-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1239576-61-4 ]
- 1
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[ 198474-90-7 ]
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[ 1239576-61-4 ]
Yield | Reaction Conditions | Operation in experiment |
74% |
|
Preparation 1; Preparation of 2-[(2S)-2-amino-3-(3,4-difluorophenyl)propyl1-1 /-/-isoindole-1 ,3(2H)-dione; a) 1 ,1-dimethylethyl [(1 S)-2-(3,4-difluorophenyl)-1-(hydroxymethyl)ethyl]carbamate; To a solution of Lambda/-[(1 ,1-dimethylethyl)oxy]carbonyl}-3,4-difluoro-L-phenylalanine (2.0 g, 6.7 mmol) in THF (35 ml.) at 0 0C stirred was added BH3-THF (30 ml_, 30 mmol- 1 M in THF). After 12h, the reaction was quenched with AcOH:MeOH (1 :4, 20 ml.) and partitioned between saturated aqueous NaHCO3 and CHCI3. The aqueous phase was then extracted several times with CHCI3. The combined organic fractions were concentrated and the resulting white solid (7.0 g, 74%) used without further purification: LCMS (ES) m/e 288 (M+H)+. |