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[ CAS No. 1251002-97-7 ] {[proInfo.proName]}

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Chemical Structure| 1251002-97-7
Chemical Structure| 1251002-97-7
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Product Details of [ 1251002-97-7 ]

CAS No. :1251002-97-7 MDL No. :MFCD18792854
Formula : C10H15BrN4O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 303.16 Pubchem ID :-
Synonyms :

Safety of [ 1251002-97-7 ]

Signal Word:Warning Class:
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 UN#:
Hazard Statements:H302-H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1251002-97-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1251002-97-7 ]

[ 1251002-97-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1251002-97-7 ]
  • [ 405520-68-5 ]
  • [ 1293995-90-0 ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,4-dioxane; water;Reflux; Inert atmosphere; General Procedure: To a solution of 8a (303 mg, 1.0 mmol, 1.0 eq), Pd(PPh3)4 (0.1 eq), and Na2CO3 (2.0 eq) in dioxane/H2O (3/1, 12 mL) was added corresponding Boronates (1.5 eq). The mixture was heated under reflux under nitrogen overnight. After addition of water (10 mL), the aqueous phase was extracted with ethyl acetate twice and the combined organic fractions were dried over magnesium sulfate and concentrated under vacuum. Products were purified by column chromatography using hexanes-ethyl acetate as eluent.
  • 2
  • [ 1245782-69-7 ]
  • [ 1251002-97-7 ]
YieldReaction ConditionsOperation in experiment
49% With NBS In acetonitrile at 0 - 20℃; tert-butyl 3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate (8a) To a solution of 7a (13.4 g, 0.06 mol) in CH3CN (150 mL) was added NBS (12.8 g, 0.072 mol) at 0 oC, and the mixture was stirred overnight at room temperature. The solution was concentrated under reduced pressure and purified by column chromatography (hexanes/EtOAc = 5/1) to obtain 8a (8.9 g, 49%) as a yellow solid. 1H NMR (CDCl3, 400 MHz): δ 1.48 (s, 9H), 3.89 (t, J = 5.2 Hz, 2H), 4.38 (t, J = 5.2 Hz, 2H), 4.57 (s, 2H).
35% With NBS In acetonitrile at 60℃; for 12h;
With NBS In acetonitrile at 0 - 20℃; for 17h; 1 Step 1: Preparation of Compound A1-2 Compound A1-1 (1 g, 4.46 mmol) was dissolved in acetonitrile (15 mL), and N-bromosuccinimide (700 mg) was added to it under ice bath. After the addition was completed, the system was stirred at 0 °C for 1 h, and then The temperature was slowly raised to room temperature and stirred for 16 h. The system was directly concentrated to obtain a crude product, which was purified by silica gel column chromatography (ethyl acetate/petroleum ether (v/v)=0-60%; flow rate: 40 mL/min) to obtain the target compound A1-2.
  • 3
  • [ 1305336-09-7 ]
  • [ 1251002-97-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: palladium(II) hydroxide; hydrogen / methanol / 50 °C 2: triethylamine / dichloromethane / 4 h / 20 °C 3: N-Bromosuccinimide / acetonitrile / 12 h / 60 °C
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