[ CAS No. 1256544-20-3 ] {[proInfo.proName]}

Name: 1256544-20-3|10-Bromonaphtho[2,1-b]benzofuran|98%
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Product Details of [ 1256544-20-3 ]

CAS No. :	1256544-20-3	MDL No. :	MFCD30470213
Formula :	C₁₆H₉BrO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	XUBMUSJSZQBFJK-UHFFFAOYSA-N
M.W :	297.15	Pubchem ID :	67775994
Synonyms :

Safety of [ 1256544-20-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P501-P273-P270-P264-P280-P337+P313-P305+P351+P338-P301+P312+P330	UN#:	N/A
Hazard Statements:	H302-H319-H413	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1256544-20-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1256544-20-3 ]

[ 1256544-20-3 ] Synthesis Path-Downstream 1~29

1
[ 121-43-7 ]
[ 1256544-20-3 ]
[ 1256544-74-7 ]

Yield	Reaction Conditions	Operation in experiment
65%	Stage #1: 10-bromonaphthalene[2,1-b]benzofuran With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 2h; Stage #2: Trimethyl borate In tetrahydrofuran; hexane at -78 - 20℃; for 5.16667h; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 20℃; for 1h;	37.37-1 Example 37; [Show Image] (37-1) Synthesis of benzo[b]naphtho[1,2-d]furan-10-boronic acid 29.7g of 10-bromobenzo[b]naphtho[1,2-d]furan and 500 mL of tetrahydrofuran (dehydrated) were placed in a flask. The resulting mixture was cooled to -78°C. 66 mL of n-BuLi (1.60M in hexane) was added thereto. While heating to 0°C, the resulting solution was stirred for 2 hours. Then, the solution was again cooled to -78°C, and 27.3g of B(OMe)3 was added thereto. After stirring at -78°C for 10 minutes, the solution was stirred at room temperature for 5 hours. After completion of the reaction, 1N HCl aq. (200 mL) was added, followed by stirring at room temperature for 1 hour. Then, the solution was transferred to a separating funnel, and extracted with ethyl acetate. After drying with MgSO4, the solution was concentrated and washed with hexane, whereby 17.0g (yield: 65%) of white solids of benzo[b]naphtho[1,2-d]furan-10-boronic acid were obtained.

Reference： [1]Current Patent Assignee: IDEMITSU KOSAN CO LTD - EP2436679, 2012, A1 Location in patent: Page/Page column 68

2
[ 116272-41-4 ]
[ 1256544-20-3 ]

Reference： [1]Patent: EP2436679,2012,A1
[2]Patent: US2017/133600,2017,A1

3
[ 1256544-20-3 ]
[ 84-65-1 ]
[ 1256545-18-2 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 10-bromonaphthalene[2,1-b]benzofuran With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 2h; Inert atmosphere; Stage #2: 9,10-phenanthrenequinone In tetrahydrofuran; hexane at -78 - 20℃; for 5h; Inert atmosphere; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 20℃; for 1h;	55.55-1 Example 55; [Show Image] (1) Synthesis of diol In the atmosphere of argon, 7.43g of intermediate (F) and 100 mL of dehydrated THF were placed in a flask. The resulting mixture was cooled to -78°C while stirring. Then, 20 mL of (1.60M) of a hexane solution of n-butyllithium was added. While heating to 0°C, the reaction solution was stirred for 2 hours. The reaction solution was again cooled to -78°C. 50 mL of a THF solution of 2.08g of 9,10-anthraquinone was added dropwise. While heating to room temperature, the reaction solution was stirred for 5 hours. 100 mL of 10% hydrochloric acid was added to the reaction solution. The solution was stirred for one hour, and then filtered. The resulting solids were washed with water and toluene, whereby 4.51 g of diol 55-(OH)2 was obtained.

Reference： [1]Current Patent Assignee: IDEMITSU KOSAN CO LTD - EP2436679, 2012, A1 Location in patent: Page/Page column 76

4
[ 148345-64-6 ]
[ 1256544-20-3 ]

Reference： [1]Patent: EP2436679,2012,A1

5
[ 1256544-18-9 ]
[ 1256544-20-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: boron tribromide / dichloromethane / 24 h / 0 - 20 °C 1.2: -78 °C 2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

Reference： [1]Current Patent Assignee: IDEMITSU KOSAN CO LTD - EP2436679, 2012, A1

6
[ 1256544-19-0 ]
[ 1256544-20-3 ]

Yield	Reaction Conditions	Operation in experiment
65%	With potassium carbonate In 1-methyl-pyrrolidin-2-one at 200℃; for 2h;	F.F-3 (F-3) Synthesis of Intermediate (F) 22.1g g of 2-hydroxy-1-(2-fluoro-5-bromophenyl)naphthalene, 300 mL of N-methyl-2-pyrrolidinone (dehydrated) and 19.3g of K2CO3 were added, followed by stirring at 200°C for 2 hours. After completion of the reaction, the solution was cooled to room temperature. Toluene (2L) was added, and the resulting mixture was transferred to a separating funnel and washed with water. After drying with MgSO4, the solution was purified by means of silica gel column chromatography, whereby white solids of 13.5g (yield: 65%) of intermediate (F) were obtained.(
59%	With potassium carbonate In 1-methyl-pyrrolidin-2-one at 180℃; for 2h;	3-3 Synthesis Example 3-(3): Synthesis of Intermediate3-c In a 2-L round-bottom flask reactor, (73.0 g, 230 mmol) and potassium carbonate (63.6 g, 460 mmol) were dissolved in N-methyl-2-pyrrolidinone (730 ml), and then stirred for 2 irs under reflux at 180° C. After completion of the reaction, the reaction mixture was cooled to room temperature. Concentration in a vacuum was followed by colunm chromatography. Recrystallization in methylene chloride and heptanes afforded (40.4 g, 59%).
	With potassium carbonate In 1-methyl-pyrrolidin-2-one

Reference： [1]Current Patent Assignee: IDEMITSU KOSAN CO LTD - EP2436679, 2012, A1 Location in patent: Page/Page column 51
[2]Current Patent Assignee: HODOGAYA CHEMICAL CO LTD - US2017/133600, 2017, A1 Location in patent: Paragraph 0162; 0163
[3]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A Location in patent: Paragraph 0051; 0056-0057; 0063; 0068-0069

7
[ 1256544-20-3 ]
[ 1256544-75-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - 0 °C 1.2: 5.17 h / -78 - 20 °C 1.3: 1 h / 20 °C 2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 8 h / Inert atmosphere; Reflux

Reference： [1]Current Patent Assignee: IDEMITSU KOSAN CO LTD - EP2436679, 2012, A1

8
C₁₇H₁₂BrFO [ No CAS ]
[ 1256544-20-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: tribromoborane / dichloromethane / 24 h / 0 - 20 °C 1.2: -78 - 20 °C 2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 180 °C
	Multi-step reaction with 2 steps 1: tribromoborane / dichloromethane 2: potassium carbonate / 1-methyl-pyrrolidin-2-one

Reference： [1]Current Patent Assignee: HODOGAYA CHEMICAL CO LTD - US2017/133600, 2017, A1
[2]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

9
10-phenylanthracene-9-boronic acid [ No CAS ]
[ 1256544-20-3 ]
C₃₆H₂₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In ethanol; water; toluene at 90℃;	3-4 Synthesis Example 3-(4): Synthesis of Compound207 In a 250-mE round-bottom flask reactor, (10.0 g, 33.7 mmol), 10-phenyl-anthracene-9- boronic acid (11.0 g, 37 mmol), tetrakis(triphenylphosphine) palladium (0.8 g, 0.7 mmol), and potassium carbonate (9.3 g, 68 mmol) were placed, followed by toluene (50 mE), ethanol (50 mE) and water (30 mE). The mixture was heated to 90° C. and stirred overnight. Afier completion of the reaction, the reaction mixture was cooled to room temperatare, and stirred together with methanol (50 ml). The precipitate thus formed was filtered and washed with methanol. Recrystallization in toluene and acetone afforded as a solid. MS (MALDI-TOF): m/z 470.17 [M]

Reference： [1]Current Patent Assignee: HODOGAYA CHEMICAL CO LTD - US2017/133600, 2017, A1 Location in patent: Paragraph 0164; 0165; 0166

10
[ 104116-17-8 ]
[ 1256544-20-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: tetrakis-(triphenylphosphine)-palladium; potassium carbonate / toluene; lithium hydroxide monohydrate; methanol / Reflux 2.1: tribromoborane / dichloromethane / 24 h / 0 - 20 °C 2.2: -78 - 20 °C 3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 180 °C
	Multi-step reaction with 3 steps 1: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; 1,2-dimethoxyethane 2: tribromoborane / dichloromethane 3: potassium carbonate / 1-methyl-pyrrolidin-2-one

Reference： [1]Current Patent Assignee: HODOGAYA CHEMICAL CO LTD - US2017/133600, 2017, A1
[2]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

11
[ 1256544-20-3 ]
[ 73183-34-3 ]
2-(benzo[b]naphtho[1,2-d]furan-10-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane for 12h; Reflux;	1.1 Step 1 Synthesis of 4,4,5,5-tetramethyl-2- (naphtho [2,1-b] benzofuran-10-yl) -1,3,2-dioxaborolane 10-bromonaphtho [2,1-b] benzofuran (50.0 g, 168.3 mmol),4,4,4 ', 4', 5,5,5 ', 5'-Octamethyl-2,2'-bis(1,3,2-dioxaborolane) (51.3 g, 201.9 mmol) and Pd (dppf) Cl2 (4.1 g, 5.1 mmol), KOAc 33.0 g, 336.5 mmol) were added to 1000 ml of dioxane and the mixture was refluxed for 12 hours. After completion of the reaction, the mixture was extracted with methylene chloride, and the mixture was filtered through MgSO4. After removing the solvent of the filtered organic layer, the desired compound 4,4,5,5-tetramethyl-2- (naphtho [2,1-b] benzofuran-10-yl) To obtain 3,2-dioxaborolane (46.3 g, yield 80%).

Reference： [1]Current Patent Assignee: DOOSAN CORP. - KR101801003, 2017, B1 Location in patent: Paragraph 0126-0129

12
10-([1,1':4',1"-terphenyl]-2'-yl)-9-anthraceneboronic acid [ No CAS ]
[ 1256544-20-3 ]
C₄₈H₃₀O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In tetrahydrofuran for 12h; Sonication; Inert atmosphere;	8 Example 8 10-([1,1':4',1"-terphenyl]-2'-yl)-9-anthraceneboronic acid 4.5g And 10-bromonaphthalene[2,1-b]benzofuran 2.7g according to a molar ratio of 1.1 to 1, Add appropriate amount of tetrahydrofuran and 30ml of 2mol/L potassium carbonate solution, Ultrasonic removal of air, Add 50 mg of tetrakis(triphenylphosphine)palladium, The reaction was carried out under nitrogen for 12 hours. After cooling to room temperature, it was extracted 3 times with dichloromethane. Wash 3 times with water, Dry over anhydrous magnesium sulfate for 2 hours. After distilling off the solvent under reduced pressure, Recrystallization from dichloromethane and n-hexane to give 2.8 g of white compound 24, yield 55%

Reference： [1]Current Patent Assignee: WUHAN SHANGSAI OPTOELECTRONICS TECHNOLOGY CO LTD - CN108203420, 2018, A Location in patent: Paragraph 0076; 0078

13
[ 1256544-20-3 ]
[ 92-67-1 ]
C₂₈H₁₉NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1.32 g	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 24h; Inert atmosphere;	4.1 (1) Preparation of intermediate M2 Under nitrogen protection, 1.5 g of 10-bromobenzofuran naphthalene, 3.8 g of 4-phenylaniline, and tris(dibenzylideneacetone)dipalladium (Pd2(dba)3) were added to a 75 ml reactor. 0.15 g of bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) 0.20 g, sodium tert-butoxide2.0 g, toluene 30 ml, nitrogen gas deoxidation for 30 min, the temperature was raised to 100 degrees, and the temperature was kept for 24.0 h. After cooling down to room temperature, filtered, the filter cake was rinsed with dichloromethane and concentrated, purified by silica gel chromatography to give 1.31 g as a pale yellow solid, is the intermediate M2. After cooling down to room temperature, filtered, the filter cake was rinsed with dichloromethane and concentrated, purified by silica gel chromatography to give 1.31 g as a pale yellow solid, is the intermediate M2.

Reference： [1]Current Patent Assignee: AAC ACOUSTIC TECHNOLOGIES HOLDINGS INC. - CN109651312, 2019, A Location in patent: Paragraph 0123-0125

14
[ 1256544-20-3 ]
C₇₂H₆₀N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 100 °C / Inert atmosphere 2: palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate / toluene / 24 h / 110 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: AAC ACOUSTIC TECHNOLOGIES HOLDINGS INC. - CN109651312, 2019, A

15
[ 1256544-20-3 ]
C₆₆H₄₈N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 100 °C / Inert atmosphere 2: palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate / toluene / 24 h / 85 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: AAC ACOUSTIC TECHNOLOGIES HOLDINGS INC. - CN109651312, 2019, A

16
[ 1256544-20-3 ]
C₇₄H₆₄N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 100 °C / Inert atmosphere 2: palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate / toluene / 24 h / 85 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: AAC ACOUSTIC TECHNOLOGIES HOLDINGS INC. - CN109651312, 2019, A

17
[ 1256544-20-3 ]
C₇₂H₄₄N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 100 °C / Inert atmosphere 2: palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate / toluene / 24 h / 85 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: AAC ACOUSTIC TECHNOLOGIES HOLDINGS INC. - CN109651312, 2019, A

18
[ 99-88-7 ]
[ 1256544-20-3 ]
C₂₅H₂₁NO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1.45 g	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 24h; Inert atmosphere;	1.1 (1) Preparation of intermediate M1 Under nitrogen protection, add 10-bromobenzofuran naphthalene 1.5g, 4-isopropylaniline 3.0g, tris(dibenzylideneacetone)dipalladium (Pd2(dba)3) to a 75ml reactor. 0.15 g of bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) 0.20 g, sodium tert-butoxide 2.0 g, toluene 30 ml, and nitrogen gas for 30 min, the temperature was raised to 100 degrees, and the temperature was kept for 24.0 h. After cooling down to room temperature, filtered, the filter cake was rinsed with dichloromethane and concentrated, purified by silica gel chromatography to give 1.45 g of a light yellow solid is the intermediate M1.

Reference： [1]Current Patent Assignee: AAC ACOUSTIC TECHNOLOGIES HOLDINGS INC. - CN109651312, 2019, A Location in patent: Paragraph 0110-0112

19
[ 1256544-20-3 ]
C₂₀H₁₅NO₂ [ No CAS ]
C₃₆H₂₃NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With 1,10-Phenanthroline; potassium carbonate; copper(I) bromide In N,N-dimethyl-formamide at 135℃; for 76h; Inert atmosphere;	8.2 (2) Intermediate A1 (42.9g, 0.142mol) was added to the reaction flask under a nitrogen atmosphere, then the raw materials C8 (42.20g, 0.142mol), DMF (430ml), 1,10-phenanthroline (0.28g, 0.0014mol), cuprous bromide (2.0g, 0.014mol), potassium carbonate (39.25g, 0.284mol), heated to 135 with stirring, the reaction 76h,After the reaction is completed, add water after cooling to precipitate a large amount of solids, filter and dry,After passing through a silica gel chromatography column and then recrystallizing with toluene, 44.10 g of intermediate B8 was obtained with a purity of> 98% and a yield of 60%.

Reference： [1]Current Patent Assignee: SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO.,LTD - CN111039936, 2020, A Location in patent: Paragraph 0165; 0169-0171

20
[ 1256544-20-3 ]
C₂₉H₂₀N₂O [ No CAS ]
C₄₅H₂₈N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; sodium t-butanolate In toluene for 7h; Inert atmosphere;	1.2 Step2: Synthesis of compound 9 Under the protection of nitrogen, the intermediate C-1 (9.07g, 22mmol), E-1 (6.54g, 22mmol), Pd2(dba)3 (0.37g, 0.40mmol), sodium tert-butoxide (4.23 g, 44 mmol) and tri-tert-butylphosphine (0.16 g, 0.80 mmol) were added to the degassed toluene solvent (150 mL) and reacted for 7 hours under reflux conditions. After the reaction stopped, the mixture was cooled to room temperature, after the reaction liquid is washed and filtered, remove the solvent under reduced pressure; use chloroform/cyclohexane (V/V=1:1) as the mobile phase for silica gel column chromatography, compound 9 (14.7 g, yield 78%) was obtained.

Reference： [1]Current Patent Assignee: CHANGCHUN HAIPU RUNSI TECHNOLOGY CO LTD - CN113105413, 2021, A Location in patent: Paragraph 0115-0116; 0119-0120

21
[ 1256544-20-3 ]
C₂₆H₁₅BrO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: n-butyllithium 2: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; toluene

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

22
[ 1256544-20-3 ]
C₅₆H₃₄O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: n-butyllithium 2: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; toluene 3: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; 1,2-dimethoxyethane; toluene

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

23
[ 1256544-20-3 ]
C₅₉H₃₆O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: n-butyllithium 2: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; toluene 3: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; 1,2-dimethoxyethane; toluene

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

24
[ 1256544-20-3 ]
C₂₆H₁₅BrO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: n-butyllithium 2: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; toluene

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

25
[ 1256544-20-3 ]
C₅₉H₃₆O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: n-butyllithium 2: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; toluene 3: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; 1,2-dimethoxyethane; toluene

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

26
[ 7647-01-0 ]
[ 121-43-7 ]
[ 1256544-20-3 ]
[ 1256544-74-7 ]

Yield	Reaction Conditions	Operation in experiment
	With n-butyllithium

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A Location in patent: Paragraph 0051; 0056-0057; 0063; 0068-0069

27
[ 2924-09-6 ]
[ 1256544-20-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: NaNO₂; potassium iodide; hydrogenchloride 2: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; 1,2-dimethoxyethane 3: tribromoborane / dichloromethane 4: potassium carbonate / 1-methyl-pyrrolidin-2-one

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

28
[ 93-04-9 ]
[ 1256544-20-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: n-butyllithium 2: tetrakis-(triphenylphosphine)-palladium; anhydrous sodium carbonate / lithium hydroxide monohydrate; 1,2-dimethoxyethane 3: tribromoborane / dichloromethane 4: potassium carbonate / 1-methyl-pyrrolidin-2-one

Reference： [1]Current Patent Assignee: EVERDISPLAY OPTRONICS (SHANGHAI) LIMITED - CN113968835, 2022, A

29
[ 1256544-20-3 ]
[ 2857019-43-1 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
58 %	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate In ethanol; water; toluene at 90℃; Inert atmosphere;	2.1 step 1: Under the protection of nitrogen, reactant A-83 (80mmol), reactant B-83 (88mmol), tetrakis (triphenylphosphine) palladium (0.8mmol) and potassium carbonate (168mmol) were added to toluene (450mL) respectively , ethanol (150mL) and water (150mL) in a mixed solvent, heat up to 90°C, and react for 10 hours. After the reaction, cool to room temperature. After the solid precipitation is complete, filter with suction, then wash with water to remove salt, and then rinse with a small amount of ethanol. Wash and dry the filter cake, place it in 1,4-dioxane and recrystallize to obtain the compound shown as intermediate C-83 (21.50g, Mw: 463.28, yield: 58%);

Reference： [1]Current Patent Assignee: JILIN OLED OPTICAL AND ELECTRONIC MATERIALS CO LTD - CN115304566, 2022, A Location in patent: Paragraph 0088-0094

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1256544-20-3 ] {[proInfo.proName]}

Quality Control of [ 1256544-20-3 ]

Related Doc. of [ 1256544-20-3 ]

Product Details of [ 1256544-20-3 ]

Safety of [ 1256544-20-3 ]

Application In Synthesis of [ 1256544-20-3 ]

[ 1256544-20-3 ] Synthesis Path-Downstream 1~29

Related Functional Groups of [ 1256544-20-3 ]

Bromides

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 1256544-20-3 ]