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[ CAS No. 1257705-09-1 ] {[proInfo.proName]}

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Chemical Structure| 1257705-09-1
Chemical Structure| 1257705-09-1
Structure of 1257705-09-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1257705-09-1 ]

CAS No. :1257705-09-1 MDL No. :MFCD31382011
Formula : C17H19N5O2S Boiling Point : -
Linear Structure Formula :- InChI Key :BYWJAVQGRJEEHH-UHFFFAOYSA-N
M.W : 357.43 Pubchem ID :67479440
Synonyms :
Chemical Name :4-(4-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-5-yl)benzyl)thiomorpholine 1,1-dioxide

Safety of [ 1257705-09-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1257705-09-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1257705-09-1 ]
  • Downstream synthetic route of [ 1257705-09-1 ]

[ 1257705-09-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1257705-09-1 ]
  • [ 4023-34-1 ]
  • [ 1206161-97-8 ]
YieldReaction ConditionsOperation in experiment
91.2% With 4-methyl-morpholine In 1,4-dioxane at 50℃; for 4 h; Green chemistry The intermediate (III) obtained in step E)With cyclopropanyl chloride in an amidated reaction in a system consisting of N-methylmorpholine and 1,4-dioxane,The amidation reaction time was 4 h,The amidation reaction temperature was 50 ° C,The molar ratio of the intermediate (III), cyclopropanyl chloride, N-methylmorpholine and 1,4-dioxane was 1: 2.8: 2.5:TLC plate to determine the reaction is completed, cooled to room temperature,Adding methylene chloride and water, separating the organic phase with water,Then washed with brine, dried over magnesium sulfate,Evaporated to dryness and the residue was purified over a silica gel column [elution solvent: ethyl acetate / n-hexane (3: 7 v / v)To obtain a solid yellowish solid,That is, Filgotinib, yield 91.2percentThe reaction of this step is the same as in Example 1.
Reference: [1] Patent: CN104987333, 2017, B, . Location in patent: Paragraph 0039; 0040; 0047; 0054; 0061
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