Alternatived Products of [ 1258392-53-8 ]
Product Details of [ 1258392-53-8 ]
CAS No. : | 1258392-53-8 |
MDL No. : | MFCD28411397 |
Formula : |
C58H78N8O8
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | WLMCRYCCYXHPQF-ZVMUOSSASA-N |
M.W : |
1015.29
|
Pubchem ID : | 49847690 |
Synonyms : |
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Safety of [ 1258392-53-8 ]
Signal Word: | Warning |
Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338 |
UN#: | N/A |
Hazard Statements: | H302 |
Packing Group: | N/A |
GHS Pictogram: |
|
Application In Synthesis of [ 1258392-53-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1258392-53-8 ]
- 1
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[ 15761-39-4 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 8 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / ethyl acetate / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: potassium hydroxide / N,N-dimethyl-formamide; toluene / 1.08 h / 0 °C
3.1: dichloromethane / 3 h / 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
7.1: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
8.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 2
-
[ 126456-43-7 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 8 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / ethyl acetate / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: potassium hydroxide / N,N-dimethyl-formamide; toluene / 1.08 h / 0 °C
3.1: dichloromethane / 3 h / 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
7.1: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
8.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
|
Multi-step reaction with 8 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C
1.2: 1 h / Reflux
2.1: 4-methyl-morpholine; chloroformic acid ethyl ester / ethyl acetate / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: dichloromethane / 3 h / 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
7.1: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
8.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
[2]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 3
-
[ 1258392-69-6 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
3: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 4
-
[ 1258392-64-1 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
With hydrogenchloride In 1,4-dioxane at 20℃; for 1h; |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 5
-
[ 1126074-18-7 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 7 steps
1: potassium hydroxide / N,N-dimethyl-formamide; toluene / 1.08 h / 0 °C
2: dichloromethane / 3 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
6: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
7: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 6
-
[ 1258392-60-7 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 6 steps
1: dichloromethane / 3 h / 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
5: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
6: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 7
-
[ 1514922-97-4 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
4: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
5: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 8
-
[ 1258392-59-4 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 7 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / ethyl acetate / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: dichloromethane / 3 h / 20 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C
5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
6.1: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 9
-
[ 1258392-70-9 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 - 20 °C
2: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]
- 10
-
[ 1258392-63-0 ]
-
[ 1258392-53-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: copper diacetate; pyridine / acetonitrile / 1 h / 80 °C
2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C |
|
Reference:
[1]Hennessy, Edward J.; Adam, Ammar; Aquila, Brian M.; Castriotta, Lillian M.; Cook, Donald; Hattersley, Maureen; Hird, Alexander W.; Huntington, Christopher; Kamhi, Victor M.; Laing, Naomi M.; Li, Danyang; MacIntyre, Terry; Omer, Charles A.; Oza, Vibha; Patterson, Troy; Repik, Galina; Rooney, Michael T.; Saeh, Jamal C.; Sha, Li; Vasbinder, Melissa M.; Wang, Haiyun; Whitston, David
[Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 9897 - 9919]