[ CAS No. 1260092-44-1 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 1260092-44-1
Chemical Structure| 1260092-44-1
Structure of 1260092-44-1

Quality Control of [ 1260092-44-1 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 1260092-44-1 ]

SDS

Product Details of [ 1260092-44-1 ]

CAS No. :1260092-44-1MDL No. :MFCD22574796
Formula :C10H19NO5Boiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :233.26Pubchem ID :-
Synonyms :

Computed Properties of [ 1260092-44-1 ]

TPSA : 84.9 H-Bond Acceptor Count : 5
XLogP3 : 0.3 H-Bond Donor Count : 2
SP3 : 0.80 Rotatable Bond Count : 8

Safety of [ 1260092-44-1 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1260092-44-1 ]

  • Upstream synthesis route of [ 1260092-44-1 ]

[ 1260092-44-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 1260092-44-1 ]
YieldReaction ConditionsOperation in experiment
30% With sodium hydroxide In tetrahydrofuran; water at 20℃; 3-(2-Amino-ethoxy)-propionic acid was dissolved in a minimal amount of deionized water before the pH was raised to 8.5 by careful addition of 1 M NaOH. After the pH adjustment, Boc2O (1 M in THF, 2 eq.) was added dropwise to the solution which was stirred overnight at room temperature. THF was removed by rotary evaporation and reaction mixture dissolved in 1:1 ethyl acetate/methanol and washed with 10percent citric acid solution. The aqueous layer was extracted three times with ethyl acetate, and two times with DCM. The organic layers were combined, dried over Na2SO4, and concentrated to dryness under vacuum. The resulting crude oil was purified by silica gel chromatography with an ethyl acetate/hexane eluent. Yield=30percent.
30% With sodium hydroxide In tetrahydrofuran; water at 20℃; 3)
3-(2-tert-Butoxycarbonylamino-ethoxy)-propionic acid
3-(2-Amino-ethoxy)-propionic acid was dissolved in a minimal amount of deionized water before the pH was raised to 8.5 by careful addition of 1 M NaOH.
After the pH adjustment, Boc2O (1 M in THF, 2 eq.) was added dropwise to the solution which was stirred overnight at room temperature.
THF was removed by rotary evaporation and reaction mixture dissolved in 1:1 ethyl acetate/methanol and washed with 10percent citric acid solution.
The aqueous layer was extracted three times with ethyl acetate, and two times with DCM.
The organic layers were combined, dried over Na2SO4, and concentrated to dryness under vacuum.
The resulting crude oil was purified by silica gel chromatography with an ethyl acetate/hexane eluent. Yield=30percent.
Reference: [1] Patent: US2013/121954, 2013, A1. Location in patent: Paragraph 0174
[2] Patent: US2015/283256, 2015, A1. Location in patent: Paragraph 0171
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