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[ CAS No. 1266336-35-9 ] {[proInfo.proName]}

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Chemical Structure| 1266336-35-9
Chemical Structure| 1266336-35-9
Structure of 1266336-35-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1266336-35-9 ]

CAS No. :1266336-35-9 MDL No. :MFCD26403563
Formula : C11H10N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 218.21 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1266336-35-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1266336-35-9 ]

[ 1266336-35-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 133446-99-8 ]
  • [ 765-30-0 ]
  • [ 1266336-35-9 ]
YieldReaction ConditionsOperation in experiment
In methanol; at 20℃; for 2h; Preparative Example 46aPreparation of 5-amino-2-cyclopropylisoindolin-1-oneStep 1: 2-cvclopropyl-5-nitroisoindoliii-1-oneAIBN (28 mg, 0.17), NBS (0.37 gram, 2.1 mmol), and the methyl 2-methyl-4-nitrobenzoate (334 g, 1.7 mmol, as prepared in Step 1, Example 44) were suspended in CCI4 (4.2 ml), the vessel evacuated and backfilled with N2 (2x) and the mixture heated under N2 at 79 C overnight. The solution was filtered, and concentrated in vacuum. The residue was dissolved in 7 N cyclopropyl amine (2.1 g, 35.9 mmol, in methanol, 18 ml), and the solution stirred for 2 hours at RT. The volatiles were removed in vacuum and the product purified by chromatography on Sitheta2 eluting with 10% acetone : DCM to give the titled compound.
  • 2
  • [ 62621-09-4 ]
  • [ 1266336-35-9 ]
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