Structure of Encorafenib
CAS No.: 1269440-17-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Encorafenib is a potent and selective B-RafV600E inhibitor, with no significant activity observed against a panel of 100 kinases (IC50>900nM).
Synonyms: LGX818
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 1269440-17-6 |
Formula : | C22H27ClFN7O4S |
M.W : | 540.01 |
SMILES Code : | O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1 |
Synonyms : |
LGX818
|
MDL No. : | MFCD25976758 |
InChI Key : | CMJCXYNUCSMDBY-ZDUSSCGKSA-N |
Pubchem ID : | 50922675 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
BRAFV600E colorectal cancer cell lines | 100 nM | 72 hours | To investigate the effect of Encorafenib alone and in combination with a BCL-XL inhibitor (A-1331852) on apoptosis, results showed that the combination significantly enhanced apoptosis. | PMC10907349 |
MDCKII-ABCB1 cells | 25.1 µM | 60 minutes | To evaluate the inhibitory effect of Encorafenib on the ABCB1 transporter, the results showed that Encorafenib could moderately increase the accumulation of daunorubicin in MDCKII-ABCB1 cells. | PMC9785850 |
MDCKII-ABCG2 cells | >20 µM | 60 minutes | To evaluate the inhibitory effect of Encorafenib on the ABCG2 transporter, the results showed that Encorafenib did not significantly affect the efflux of mitoxantrone within the tested concentration range. | PMC9785850 |
MDCKII-ABCC1 cells | 8.63 µM | 60 minutes | To evaluate the inhibitory effect of Encorafenib on the ABCC1 transporter, the results showed that even at low concentrations, Encorafenib could significantly increase the accumulation of daunorubicin in MDCKII-ABCC1 cells. | PMC9785850 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
NOD Scid gamma mice | COLO 201 xenograft model | Oral gavage | 20 mg/kg | bi-daily, for 22 days | To investigate the effect of Encorafenib in combination with the BCL-2/BCL-XL inhibitor AZD0466 on tumor growth, results showed that the combination significantly suppressed tumor growth. | PMC10907349 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01436656 | Melanoma and Metastatic Colore... More >>ctal Cancer Less << | PHASE1 | COMPLETED | 2022-11-07 | H Lee Moffitt Cancer Center an... More >>d Research Institute, Tampa, Florida, 33612, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Western Sydney Local Health District, Westmead, New South Wales, 2145, Australia|Westmead Hospital- Redbank Rd, Westmead, New South Wales, 2145, Australia|Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia|EDOG - Institut Claudius Regaud - PPDS, Toulouse, Haute-garonne, 31059 Cedex 9, France|Institut Gustave Roussy, Villejuif, ILE DE France - VAL DE Marne (94), 94800, France|Institut Gustave Roussy, Villejuif, VAL DE Marne, 94800, France|Institut Gustave Roussy, Villejuif Cedex, Val-de-marne, 94805, France|Institut Gustave Roussy, Villejuif, Val-de-marne, 94805, France|Institut Gustave Roussy, Villejuif, 94805, France|National Cancer Center Hospital, Chuo-ku, Tokyo, 104-0045, Japan|Oslo Myeloma Center - PPDS, Oslo, 00424, Norway|Hospital Clinic de Barcelona, Badalona, 08036, Spain|Hospital General Vall d'Hebron, Barcelona, 08035, Spain|Hospital Universitario Vall d'Hebron - PPDS, Barcelona, 08035, Spain|Hospital Universitario Vall d'Hebron, Barcelona, 08035, Spain|Hospital Universitario Vall d'Hebron - PPDS, Barcelona, 8035, Spain|Hospital Universitario HM Sanchinarro_CIOCC, Madrid, 28050, Spain|START MADRID_Hospital Universitario HM Sanchinarro - CIOCC, Madrid, 28050, Spain|Kantonsspital Graubünden, Chur, Graubünden (DE), 07000, Switzerland|Universit?t Zürich, Zürich, 8091, Switzerland Less << |
NCT01894672 | Melanoma | PHASE2 | COMPLETED | 2016-03-17 | Memorial Sloan Kettering Cance... More >>r Center at Basking Ridge, Basking Ridge, New Jersey, United States|Memorial Sloan Kettering Cancer Center at Commack, Commack, New York, 11725, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|Memorial Sloan Kettering Cancer Center at Mercy Medical Center, Rockville Centre, New York, 11570, United States|Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center, Sleepy Hollow, New York, 10591, United States Less << |
NCT02109653 | Non-Small Cell Lung Cancer | PHASE2 | WITHDRAWN | 2025-11-17 | University of Chicago Medical ... More >>Center SC-2, Chicago, Illinois, 60546, United States Less << |
NCT01981187 | Solid Tumor|Hematologic Malign... More >>ancies Less << | PHASE2 | TERMINATED | 2015-10-13 | Alabama Oncology St. Vincent's... More >> Birmingham, Birmingham, Alabama, 35211, United States|Highlands Oncology Group Highlands Oncology Group (22), Fayetteville, Arkansas, 72703, United States|Yale University School of Medicine Smilow Cancer Hospital, New Haven, Connecticut, 06520, United States|Whittingham Cancer Center Norwalk Hospital, Norwalk, Connecticut, 06856, United States|Florida Cancer Specialists Florida Cancer Specialists (31, Fort Myers, Florida, 33901, United States|Lurie Children's Hospital of Chicago Developmental Therapeutics, Chicago, Illinois, 60611, United States|Comprehensive Cancer Centers of Nevada CCC of Nevada (1), Las Vegas, Nevada, 89109, United States|Genesis Cancer Services, Zanesville, Ohio, 43701, United States|University of Pennsylvania Presbyterian Medical Center University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|Sanford Research Sanford Health, Sioux Falls, South Dakota, 57104, United States|Oncology Consultants Oncology Group, Houston, Texas, 77024, United States|Utah Cancer Specialists Utah Cancer Specialists (11), Salt Lake City, Utah, 84106, United States|Shenandoah Oncology Shenadoah Oncology (2), Winchester, Virginia, 22601, United States Less << |
NCT05003622 | BRAF V600E Unresectable or Met... More >>astatic Melanoma|BRAF V600E Metastatic NSCLC|Melanoma Less << | PHASE1 | COMPLETED | 2022-05-06 | Sun Yat-sen University Cancer ... More >>Center, Guangzhou, Guangdong, 510060, China Less << |
NCT01820364 | Melanoma | PHASE2 | TERMINATED | 2025-03-15 | Sarah Cannon Research Institut... More >>e Onc Dept, Nashville, Tennessee, 37203, United States|Novartis Investigative Site, East Melbourne, Victoria, 3002, Australia|Novartis Investigative Site, Edmonton, Alberta, T6G 1Z2, Canada|Novartis Investigative Site, Heidelberg, 69120, Germany|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Zuerich, 8091, Switzerland Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.85mL 0.37mL 0.19mL |
9.26mL 1.85mL 0.93mL |
18.52mL 3.70mL 1.85mL |
Tags: Encorafenib | LGX818 | LGX 818 | LGX-818 | Raf | Raf kinases | BRAF BRAFV600E | BRAF inhibitor | MAPK/ERK pathway | V600E mutation | 1269440-17-6
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P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
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P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
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P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
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P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
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H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
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H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
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Health hazards | |
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H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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