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Chemical Structure| 129850-61-9 Chemical Structure| 129850-61-9

Structure of 129850-61-9

Chemical Structure| 129850-61-9

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Product Details of [ 129850-61-9 ]

CAS No. :129850-61-9
Formula : C17H33NO4
M.W : 315.45
SMILES Code : CCCCCCCCCCC(NC(OC(C)(C)C)=O)C(O)=O
English Name :2-((tert-Butoxycarbonyl)amino)dodecanoic acid
MDL No. :MFCD08275830

Safety of [ 129850-61-9 ]

Application In Synthesis of [ 129850-61-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 129850-61-9 ]

[ 129850-61-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 35237-37-7 ]
  • [ 24424-99-5 ]
  • [ 129850-61-9 ]
YieldReaction ConditionsOperation in experiment
54% Alkaline conditions; 2-Aminododecanoic acid was synthesised as described in the literature with 1-bromodecane and diethyl acetoamidomalonate.26 The free amine of 2-aminohexadecanoic acid was then Boc-protected by reaction with di-tert-butyl dicarbonate in a basic environment as previously reported.26,41 C12 was prepared to afford the pure product in 54.0% yield (1.31g): Rf=0.65 (DCM/MeCN/AcOH); ESI-MS (C17H33NO4, 315.2): m/z=316.4 [M+H]+ (calcd 316.2), 338.2 [M+Na]+ (calcd 338.2); 1H NMR: delta=4.94-4.92 (1H, d, J 7.1Hz, OCONH), 4.26 (1H, m, alpha-CH), 1.82-1.67 (2H, m, beta-CH), 1.42 (9H, s, C(CH3)3), 1.23 (16H, br s, 8CH2), 0.86 (3H, t, J 7.0Hz, CH3).
  • 2
  • [ 73821-97-3 ]
  • [ 129850-61-9 ]
  • [ 47355-10-2 ]
  • HOCOCH2CH2CHNHCOCH(CH2)9CH3NHCOCHNH2(CH2)9CH3CONHCHCH2C8H6NCONH2 [ No CAS ]
  • 3
  • [ 73821-97-3 ]
  • [ 129850-61-9 ]
  • [ 47355-10-2 ]
  • HOCOCH2CH2CHNHCOCH(CH2)9CH3NHCOCHNH2(CH2)2CO2HCONHCHCH2C8H6NCONH2 [ No CAS ]
  • 4
  • [ 129850-61-9 ]
  • [ 6232-91-3 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
62% Stage #1: 2-(tert-butoxycarbonylamino)dodecanoic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 5-methoxy-1H-benzimidazol-2-amine In N,N-dimethyl-formamide at 20℃; for 16h; 4.1.2.9. General procedure for the preparation of amides of types III and IV, BZs 31 to 55. General procedure: The procedure applied was similar to that indicated in Section 4.1.2.5 . To a solution of the correspond- ing acid (0.31 mmol) in dry DMF (1 mL), 1,1-carbonyldiimidazole (0.31 mmol) was added, and the mixture maintained at room tem- perature for 1 h. Then, the corresponding 2-aminobenzimidazole intermediate (0.22 mmol) was added and the mixture maintained at room temperature with magnetic stirring for 16 h. The progress of the reaction was monitored by TLC using ethyl acetate as eluent. After the reaction completion, the solvent was removed in vacuum and the crude product chromatographed on silica gel using ethyl acetate as eluent. BZ yields ranged within 20-73%.
 

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