Structure of Icatibant
CAS No.: 130308-48-4
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Icatibant is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
Synonyms: HOE 140
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 130308-48-4 |
Formula : | C59H89N19O13S |
M.W : | 1304.52 |
SMILES Code : | [H][C@]1(C[C@@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)N2C([C@@H]3N(C([C@H](CO)NC([C@H](CC4=CC=CS4)NC(CNC([C@@H]5C[C@@H](O)CN5C([C@H]6N(C([C@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)CCC6)=O)=O)=O)=O)=O)CC7=C(C=CC=C7)C3)=O)[C@]2([H])CCCC1 |
Synonyms : |
HOE 140
|
MDL No. : | MFCD00213940 |
InChI Key : | QURWXBZNHXJZBE-SKXRKSCCSA-N |
Pubchem ID : | 6918173 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02584959 | Hereditary Angioedema (HAE) | Phase 3 | Completed | - | - |
NCT02584959 | - | Completed | - | - | |
NCT02826356 | - | Completed | - | France ... More >> Hospices Civils de Lyon, Département d'Anesthésie-Réanimation, Hôpital Edouard Herriot, Lyon, France. Lyon, France, 69003 Less << | |
NCT03005184 | Heart Failure NYHA Class I ... More >> Heart Failure NYHA Class II Heart Failure NYHA Class III Less << | Phase 2 | Withdrawn(Study is being redes... More >>igned and submitted as a new study.) Less << | January 2020 | United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less << |
NCT00965393 | Ischaemic Heart Diseases | Not Applicable | Completed | - | United Kingdom ... More >> University of Edinburgh, 49 Little France Crescent Edinburgh, United Kingdom, EH16 4SB Less << |
NCT00965120 | Ischaemic Heart Diseases | Not Applicable | Completed | - | United Kingdom ... More >> University of Edinburgh, 49 Little France Crescent Edinburgh, United Kingdom, EH16 4SB Less << |
NCT00223704 | Cardiopulmonary Bypass ... More >> Inflammation Fibrinolysis Surgery Less << | Phase 2 Phase 3 | Completed | - | United States, Tennessee ... More >> TN Valley Healthcare System Nashville, Tennessee, United States, 37212 Vanderbilt University Nashville, Tennessee, United States, 37232 Less << |
NCT00223704 | - | Completed | - | - | |
NCT01574248 | ACE Inhibitor-associated Angio... More >>edema Less << | Phase 4 | Terminated(DSMC recommended di... More >>scontinuation for futility and feasibility) Less << | - | United States, California ... More >> University of California, San Diego San Diego, California, United States, 92093 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37235 Less << |
NCT01154361 | Angioedema | Phase 2 | Completed | - | Germany ... More >> Klinikum rechts der Isar Hals-Nasen-Ohrenklinik der TUM Munich, Bavaria, Germany, 81675 Less << |
NCT01574248 | - | Terminated(DSMC recommended di... More >>scontinuation for futility and feasibility) Less << | - | - | |
NCT00517582 | Angioneurotic Edema | Phase 1 | Terminated(This study was stop... More >>ped to allow initiation of a mult-center study) Less << | - | United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37205 Less << |
NCT01034969 | - | Recruiting | May 24, 2023 | - | |
NCT03177798 | Hemodialysis-Induced Symptom ... More >> Mitochondrial Diseases Less << | Phase 2 | Active, not recruiting | December 31, 2018 | United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Less << |
NCT00500656 | Hereditary Angioedema | Phase 3 | Completed | - | Italy ... More >> Università degli Studi di Milano, Dipartimento di Medicina Interna Milano, Italy, 20123 Less << |
NCT00097695 | Angioedema | Phase 3 | Completed | - | United States, District of Col... More >>umbia Georgetown University Hospital, Lombardi Cancer Center Washington, District of Columbia, United States, 20007-2197 Less << |
NCT00303056 | Joint Disease | Phase 2 | Completed | - | United States, New Jersey ... More >> Administrative Office Bridgewater, New Jersey, United States, 08807 Austria Administrative Office Vienna, Austria, DCA 1220 Czech Republic Administrative Office Praha, Czech Republic, 160 00 Germany Administrative Office Berlin, Germany, D-10785 Poland Administrative Office Warszawa, Poland, 02-672 Less << |
NCT01457430 | Hereditary Angioedema | Phase 4 | Completed | - | United States, California ... More >> San Diego Veterans Affairs Medical Center La Jolla, California, United States UCLA - David Geffen School of Medicine Los Angeles, California, United States United States, Maryland Institute for Allergy and Asthma Wheaton, Maryland, United States, 20902 United States, Pennsylvania Penn State University Hershey, Pennsylvania, United States, 17033 United States, Texas AARA Research Center Dallas, Texas, United States, 75231 Less << |
NCT00912093 | Hereditary Angioedema | Phase 3 | Completed | - | - |
NCT00097695 | - | Completed | - | - | |
NCT01457430 | - | Completed | - | - | |
NCT01919801 | Angiotensin Converting Enzyme ... More >>Inhibitor Induced Angioedema Less << | Phase 3 | Completed | - | - |
NCT00500656 | - | Completed | - | - | |
NCT01919801 | - | Completed | - | - | |
NCT00997204 | Hereditary Angioedema | Phase 3 | Completed | - | Argentina ... More >> Hospital Britanico Unidad de Alergia Buenos Aires, Argentina, C1035AAT Austria Universitätsklinik für Dermatologie und Venerologie Graz, Austria, 8036 Denmark Odense Universitetshospital-OUH Odense, I og Alergicentret, Denmark France Centre Hospitalier Universitaire/ Service de Dermatologie Angers, Angers Cedex 09, France, 49933 Hospital Edouaed Herriot Lyon, Cedex 03, France, 69437 Clinique Universitaire de Medicine/ Centre National de reference Grenoble, Grenoble Cedex 09, France, 38043 Hopital Claude Huriex/ Service de medicine interne Lille, Lille Cedex, France, 59037 Hopital Europeen Georges Pompidou Immunologie Clinique Paris, Paris Cedex 15, France, 75015 Germany Universitätsmedizin Berlin, Klinik für Dermatologie, Venerologie und Allergologie, Charité Berlin, Germany, 10117 Universitäts-Hals-Nasen-Ohren-Klinik Essen, Universität Duisburg-Essen Essen, Germany, 45127 Klinkum der Johann Wolfgang Goethe-Universitat Frankfurt am Main, Germany, 60590 Hautklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Germany, 55101 Israel Bnai-Zion M.C. Clinical Immunology and Allergy Division Haifa, Israel, 31048 Tel Aviv Sourasky Medical Center - Allergy Unit Tel Aviv, Israel, 64239 The Chaim Sheba Medical Center, The Allergy and Clinical Immunology Unit Tel Hashomer, Israel, 52621 Italy Ospedale Luigi Sacco Milano, Italy, 20157 Universita degli Studi di Napoli 'Federico II' Napoli,, Italy, 80131 Spain Hospital Universitario Vall de Hebrón / Sección de Alergia, Escola Infermeria Barcelona, Spain, 08035 Hospital General Universitario Gregorio Maranon Madrid, Spain, 28007 Hospital Universitario La Paz, Servicio de Alergia Madrid, Spain, 28046 Hospital Universitario La Fe, Servicio de Alergia Valencia, Spain, 46009 Switzerland Luzerner Kantonsspital Luzern, Switzerland Universitätsspital Zürich / Dermatologische Klinik Zurich, Switzerland, 8091 United Kingdom Southmead Hospital, Department of Immunology Bristol, United Kingdom, BS10 5NB Barts & The London NHS Trust, Pathology and Pharmacy Building London, United Kingdom, E1 2ES Derriford Combined Laboratory, Department of Clinical Immunology & Allergy Plymouth, United Kingdom, PL6 8DH Less << |
NCT00997204 | - | Completed | - | - | |
NCT02045264 | Hereditary Angioedema (HAE) | Phase 1 | Completed | - | United States, California ... More >> PAREXEL Glendale, California, United States, 91206 Less << |
NCT02045264 | - | Completed | - | - | |
NCT00912093 | - | Completed | - | - | |
NCT01386658 | Hereditary Angioedema (HAE) | Phase 3 | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
0.77mL 0.15mL 0.08mL |
3.83mL 0.77mL 0.38mL |
7.67mL 1.53mL 0.77mL |
Tags: Icatibant | HOE 140 | Bradykinin Receptor | GPCR/G Protein | 130308-48-4
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL