[ CAS No. 131-53-3 ]

Name: 131-53-3|(2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone|98%
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Quality Control of [ 131-53-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 131-53-3 ]

CAS No. :	131-53-3	MDL No. :	MFCD00002218
Formula :	C₁₄H₁₂O₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MEZZCSHVIGVWFI-UHFFFAOYSA-N
M.W :	244.24 g/mol	Pubchem ID :	8569
Synonyms :	1. Dioxybenzone

Safety of [ 131-53-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 131-53-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 131-53-3 ]

[ 131-53-3 ] Synthesis Path-Downstream 1~31

1
[ 33077-87-1 ]
[ 3722-51-8 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine hydrochloride

Reference： [1]Van Allan [Journal of Organic Chemistry, 1958, vol. 23, p. 1679,1682]

2
[ 21615-34-9 ]
[ 151-10-0 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
	With aluminium trichloride; chlorobenzene

Reference： [1]Current Patent Assignee: PFIZER INC - US2853521, 1956, A

3
[ 103-82-2 ]
[ 917-64-6 ]
[ 131-53-3 ]
(Z,E)-4-(2-hydroxy-4-methoxyphenyl)-4-(2'-hydroxyphenyl)-2-methyl-3-phenylbut-3-en-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multistep reaction;

Reference： [1]Sharma, Indra; Salman, M.; Koley, P. L.; Ray, Suprabhat [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 6, p. 567 - 570]

4
[ 150-19-6 ]
[ 69-72-7 ]
[ 131-53-3 ]

Reference： [1]Sharma, Indra; Salman, M.; Koley, P. L.; Ray, Suprabhat [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 6, p. 567 - 570]

5
[ 131-53-3 ]
[ 3722-51-8 ]

Yield	Reaction Conditions	Operation in experiment
69%	With pyridine hydrochloride at 210 - 215℃; for 6h;

Reference： [1]Han; Bontems; Hegyes; Munson; Minor; Kates; Albericio; Barany [Journal of Organic Chemistry, 1996, vol. 61, # 18, p. 6326 - 6339]

Yield	Reaction Conditions	Operation in experiment
	d. Triol, Me2SO4, in wss Alkali;
		As examples of the benzophenone-type ultraviolet absorber, the following can be mentioned but should not be considered limiting: 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-octyloxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, bis(5-benzoyl-4-hydroxy-2-methoxyphenyl)methane, 2,2',4,4'-tetrahydroxybenzophenone,
		The preferred compounds to which the invention is applicable, but not limited, include the following: 2,4-dihydroxybenzophenone 2,2',4-trihydroxybenzophenone 2,2'4,4'-tetrahydroxybenzophenone 2,2'-dihydroxy-4-methoxybenzophenone 2,2'-dihydroxy-4,4'-dimethoxybenzophenone 2-hydroxy-4-methoxybenzophenone 2-hydroxy-4-octyloxybenzophenone 2-hydroxy-4-dodecyloxybenzophenone.

		Examples of the ultraviolet absorber include the following: 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-octoxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, bis(5-benzoyl-4-hydroxy-2-methoxyphenyl)methane, 2,2',4,4'-tetrahydroxybenzophenone, 2-(2-hydroxy-5-methylphenyl)benzotriazole, 2-[2-hydroxy-3-(3,4,5,6-tetrahydrophthalimidemethyl)-5-methylphenyl]benzotriazole, 2-(3-t-butyl-2-hydroxy-5-methylphenyl)-5-chlorobenzotriazole, 2-(2-hydroxy-5-t-octylphenyl)benzotriazole, ...
		The following benzophenones: 2,4-Dihydroxybenzophenone 2,2'-Dihydroxy-4-methoxybenzophenone 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone
		X2 and Z3 are different from Y and cannot simultaneously assume the meaning Z1 or Z2 or Z3; and a benzphenone selected from the group consisting of ... 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2,4-dihydroxybenzophenone, and 2,2'-dihydroxy-4-methoxybenzophenone,
		Illustrative examples of the above described benzophenones are listed below. 2-Hydroxy-4-methoxybenzophenone, 2,2'-Dihydroxy-4-methoxybenzophenone, 2-Hydroxy-4-methoxy-2'-carboxybenzophenone, 2,2-dihydroxy-4-n-octoxybenzophenone, 2-hydroxy-4-n-octoxybenzophenone, 5-chloro-2-hydroxybenzophenone, 2,4-dihydroxybenzophenone, 4-dodecycloxy-2-hydroxybenzophenone, 2-hydroxy-4-decyloxybenzophenone, ...
		Specific examples of bisphenols include: ... bis(4-hydroxy-2-nitrophenyl)sulfone; 4,4'-dihydroxybenzophenone; 2,2'-dihydroxy-4-methoxybenzophenone; 4,4'-dihydroxydiphenyl ether; ...
		Broadband filters which are preferably combined with one or more compounds of formula (I) in a preparation according to the present invention are selected from the group consisting of ● 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (Neo Heliopan303)● ethyl-2-cyano-3,3'-diphenyl acrylate● 2-hydroxy-4-methoxybenzophenone (Neo HeliopanBB)● 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid● dihydroxy-4-methoxybenzophenone● 2,4-dihydroxybenzophenone● tetrahydroxybenzophenone● 2,2'-dihydroxy-4,4'-dimethoxybenzophenone● 2-hydroxy-4-n-octoxybenzophenone...
		Broadband filters which are preferably combined with one or more compounds of formula (I) in a preparation according to the present invention are selected from the group consisting of 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (Neo Heliopan303)ethyl-2-cyano-3,3'-diphenyl acrylate2-hydroxy-4-methoxybenzophenone (Neo HeliopanBB)2-hydroxy-4-methoxybenzophenone-5-sulfonic aciddihydroxy-4-methoxybenzophenone2,4-dihydroxybenzophenonetetrahydroxybenzophenone2,2'-dihydroxy-4,4'-dimethoxybenzophenone2-hydroxy-4-n-octoxybenzophenone...
		Ultraviolet absorbers are illustrated below, but the embodiments of the present invention are not limited to these compounds: benzophenone-based ultraviolet absorbers such as 2,4-dihydroxybenzophenone,...bis-(2-methoxy-4-hydroxy-5-benzoylphenyl)methane,2-(2'-hydroxy-3',5'-di-t-amylphenyl)-benzophenone,2-hydroxy-4-dodecyloxybenzophenone,2-hydroxy-4-octadecyloxybenzophenone,2,2'-dihydroxy-4-methoxybenzophenone, and2-hydroxy-4-benzyloxybenzophenone;para-t-butylphenyl salicylate,paraoctylphenyl salicylate,...

7
[ 131-53-3 ]
[ 161110-86-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 69 percent / Py*HCl / 6 h / 210 - 215 °C 2: 86 percent / K₂CO₃ / acetone / 8 h / Heating 3: 1.) NaOH, 2.) HCl / 1.) EtOH, H₂O, 25 deg C, 4 h, 2.) H₂O, pH 3.5.

Reference： [1]Han; Bontems; Hegyes; Munson; Minor; Kates; Albericio; Barany [Journal of Organic Chemistry, 1996, vol. 61, # 18, p. 6326 - 6339]

8
[ 131-53-3 ]
[ 161110-85-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 69 percent / Py*HCl / 6 h / 210 - 215 °C 2: 86 percent / K₂CO₃ / acetone / 8 h / Heating

Reference： [1]Han; Bontems; Hegyes; Munson; Minor; Kates; Albericio; Barany [Journal of Organic Chemistry, 1996, vol. 61, # 18, p. 6326 - 6339]

9
[ 131-53-3 ]
5-(xanthen-3-yloxy)valeric acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 69 percent / Py*HCl / 6 h / 210 - 215 °C 2: 86 percent / K₂CO₃ / acetone / 8 h / Heating 3: 1.) NaOH, 2.) HCl / 1.) EtOH, H₂O, 25 deg C, 4 h, 2.) H₂O, pH 3.5. 4: 1.) NaBH₄, NaOH, 2.) NaHCO₃ / 1.) H₂O, 50-55 deg C, 3 h, pH 8.0-8.5, 2.) 10 deg C, 1 h.

Reference： [1]Han; Bontems; Hegyes; Munson; Minor; Kates; Albericio; Barany [Journal of Organic Chemistry, 1996, vol. 61, # 18, p. 6326 - 6339]

10
[ 131-53-3 ]
5-[9-(9H-Fluoren-9-ylmethoxycarbonylamino)-9H-xanthen-3-yloxy]-pentanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: 69 percent / Py*HCl / 6 h / 210 - 215 °C 2: 86 percent / K₂CO₃ / acetone / 8 h / Heating 3: 1.) NaOH, 2.) HCl / 1.) EtOH, H₂O, 25 deg C, 4 h, 2.) H₂O, pH 3.5. 4: 1.) NaOH, Zn, 2.) TFA / 1.) aq. EtOH, reflux, 6 h, 2.) 1,2-dimethoxyethane, 25 deg C, 4 h.

Reference： [1]Han; Bontems; Hegyes; Munson; Minor; Kates; Albericio; Barany [Journal of Organic Chemistry, 1996, vol. 61, # 18, p. 6326 - 6339]

11
[ 21615-34-9 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 2: pyridine hydrochloride

Reference： [1]Van Allan [Journal of Organic Chemistry, 1958, vol. 23, p. 1679,1682]

12
[ 151-10-0 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 2: pyridine hydrochloride

Reference： [1]Van Allan [Journal of Organic Chemistry, 1958, vol. 23, p. 1679,1682]

13
[ 79-43-6 ]
[ 131-53-3 ]
3-methoxy-12H-dibenzo[d,g][1,3]dioxocin-12-one-6-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium iodide; potassium carbonate In water; ethyl acetate; isopropyl alcohol	22 Preparation of Methyl 3-Methoxy-12H-dibenzo[d,g][1,3]dioxocin-12-one-6-carboxylate Example 22 Preparation of Methyl 3-Methoxy-12H-dibenzo[d,g][1,3]dioxocin-12-one-6-carboxylate (2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone (16.1 g, 65.9 mmol), 36.5 g (258 mmol) of potassium carbonate, and 3.00 g (18 mmol) of potassium iodide were suspended in 250 ml of 2-propanol and heated with stirring. Dichloroacetic acid (6.00 ml, 72.6 mmol) was added slowly with a syringe and the mixture heated at reflux with stirring. After 48 hours another 5.00 ml of dichloroacetic acid was added and the reaction continued for another 48 hours. The mixture was then allowed to cool and was concentrated by evaporation under reduced pressure to obtain a solid residue. The residue was dissolved in 500 ml of water and the solution extracted with 200 ml of ether. The aqueous layer was then acidified with concentrated aqueous hydrochloric acid and then extracted twice with 500 ml portions of ether and once with 300 ml of ethyl acetate. The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure to obtain 3-methoxy- 12H-dibenzo[d,g][1,3]dioxocin-12-one-6-carboxylic acid as a semi-solid residue.

Reference： [1]Current Patent Assignee: DOW INC - US4979978, 1990, A

14
[ 611-94-9 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: palladium diacetate; dipotassium peroxodisulfate / 4 h / 50 °C 2: silica gel / hexane; dichloromethane

Reference： [1]Mo, Fanyang; Trzepkowski, Louis J.; Dong, Guangbin [Angewandte Chemie - International Edition, 2012, vol. 51, # 52, p. 13075 - 13079][Angew. Chem., 2012, vol. 124, # 52, p. 13252 - 13256,5]

15
C₁₈H₁₀F₆O₆ [ No CAS ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
	With silica gel In hexane; dichloromethane

16
[ 131-57-7 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
82%	With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; trifluoroacetic anhydride at 25 - 30℃; for 48h; regioselective reaction;
82%	With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; trifluoroacetic anhydride at 20℃; regioselective reaction;
51%	With dipotassium peroxodisulfate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; trifluoroacetic acid; trifluoroacetic anhydride at 80℃; for 20h; Sealed tube; regioselective reaction;

Reference： [1]Shan, Gang; Yang, Xinglin; Ma, Linlin; Rao, Yu [Angewandte Chemie - International Edition, 2012, vol. 51, # 52, p. 13070 - 13074][Angew. Chem., 2012, vol. 124, # 52, p. 13247 - 13251,5]
[2]Rao, Yu [Synlett, 2013, vol. 24, # 19, p. 2472 - 2476]
[3]Shan, Gang; Han, Xuesong; Lin, Yun; Yu, Shanyou; Rao, Yu [Organic and Biomolecular Chemistry, 2013, vol. 11, # 14, p. 2318 - 2322]

17
[ 673-22-3 ]
[ 90-02-8 ]
[ 131-54-4 ]
[ 835-11-0 ]
[ 131-53-3 ]

Reference： [1]RSC Advances,2016,vol. 6,p. 75505 - 75511

18
[ 33077-87-1 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
85%	With hydrogen bromide; acetic acid at 110℃;	2.2 synthesis of 2, 2'-dihydroxy-4-methoxybenzophenone Weighed 60 mL of glacial acetic acid and hydrobromic acid (48%) and 2, 2 ', 4-trimethoxybenzophenone(0.18 mol) in a three-necked flask, the reaction temperature was controlled at 110 ° C for 5 to 6 hours,The reaction mixture was cooled and washed with water to remove the acidic substance. The mixture was separated and extracted with ethyl acetate. After drying, the ethyl acetate was removed by evaporation to give an oily substance, which was recrystallized from 150 ml of n-hexane as a solvent and the temperature was controlled at 0 to 5 ° C Crystallization, filtration, drying under reduced pressure to get pale yellow crystalline powder 2, 2 '-dihydroxy-4-methoxybenzophenone 37. 3g.The yield was 85%, mp 67 ~ 69 ° C, and the content was 99.0% by HPLC.

Reference： [1]Current Patent Assignee: HUBEI MEIKAI CHEMICAL; UNIV HUBEI POLYTECHNIC - CN104058945, 2016, B Location in patent: Paragraph 0028; 0029; 0031

19
[ 13087-18-8 ]
[ 77-78-1 ]
[ 131-53-3 ]

Yield	Reaction Conditions	Operation in experiment
74.43%	With sulfolane; sodium carbonate; zinc(II) chloride In toluene at 45℃; for 2h;	2 Example 2 Weighing 250 g sulfolane, 100 ml phosphorus oxychloride, 150 g (0.2 µM) anhydrous zinc chloride, adding with stirring 1000 ml in the reaction bottle, heated to 55 °C reaction 1 hours, then adding salicylic acid 72.5 g (0.53 µM), resorcinol 55.0 g (0.5 µM), heated to 72 °C reaction 2 hours, after the reaction cooling the dripping water 50 ml the termination of the reaction, the reaction solution is poured into 1000 ml of ice water reaction mixing and 10 hours, cooling crystallization, at room temperature the product is collected after filtering, drying after heavy 108.3 g, GC detection 2, 2', 4 - trihydroxy benzophenone content 95.20%, yield is 94.17%;

Reference： [1]Current Patent Assignee: YIDU HUAYANG CHEMICAL - CN104945234, 2017, B Location in patent: Paragraph 0028; 0029; 0032; 0033; 0036; 0037; 0040-0045

20
[ 131-53-3 ]
[ 13087-18-8 ]

Yield	Reaction Conditions	Operation in experiment
	With boron tribromide In dichloromethane at -78 - 20℃;	5.1 To reaction flask charged with a suspension of (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone (24 g, 81.88 mmol) in 50 mL dichloromethane, was added BBr3 (50 g, 163.77 mmol) (50 g in 100 mL of dichloromethane) dropwise over a period of 30 min at -78° C. The resultant solution was slowly warmed to room temperature and stirring continued overnight. Saturated aqueous NaCl (150 mL) solution was carefully added to the reaction mixture while stirring. After phases were separated, the organic phase was retained and the aqueous layer was extracted with dichloromethane (2×200 mL). The organic extracts were combined, washed twice with brine (100 mL) and dried over anhydrous magnesium sulfate. After removal of the solids and evaporation of the solvent, the filtrate offered a product which was purified by combiflash on silica gel eluting with dichloromethane/ethyl acetate (EtOAc) (90/10, v/v). The product thus obtained was a light yellow solid, used directly for the next step. NMR showed that the product had a structure consistent with (2,4-dihydroxyphenyl)(2-hydroxyphenyl)methanone.
	With boron tribromide In dichloromethane for 48h; Inert atmosphere;

Reference： [1]Current Patent Assignee: ESSILORLUXOTTICA - US2017/275534, 2017, A1 Location in patent: Paragraph 0254
[2]Zhan, Tingjie; Zhang, Leili; Cui, Shixuan; Liu, Weiping; Zhou, Ruhong; Zhuang, Shulin [Environmental Pollution, 2021, vol. 268]

21
[ 131-53-3 ]
[ 920-46-7 ]
C₂₂H₂₀O₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In dimethyl sulfoxide at 20℃; for 12h;	1.1 1) Preparation of second monomer (UV blocking monomer) using Dioxybenzone 1 g of dioxybenzone was dissolved in 10 ml of DMSO solution, 0.5 ml of methacryloyl chloride was added.The resulting precipitate was filtered through a reaction at room temperature for 12 hours,The precipitate was dried at room temperature for 24 hours or more, A second monomer, methacryloyl dioxybenzone, was prepared.

Reference： [1]Current Patent Assignee: CATHOLIC UNIVERSITY OF KOREA - KR2018/94797, 2018, A Location in patent: Paragraph 0016; 0058; 0059; 0060

22
[ 131-53-3 ]
(M,S)-7-butyl-3-methoxy-7,8-dihydro-6H-benzo[2,3]oxocino[5,4-b]benzofuran-6-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tetrahydrofuran / 3 h / 0 - 70 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; (5aR,10bS)-2-mesityl-5a,10b-dihydro-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoroborate / dichloromethane / 36 h / 24 °C / Molecular sieve; Inert atmosphere

Reference： [1]Lu, Shenci; Ong, Jun-Yang; Yang, Hui; Poh, Si Bei; Liew, Xi; Seow, Chwee San Deborah; Wong, Ming Wah; Zhao, Yu [Journal of the American Chemical Society, 2019, vol. 141, # 43, p. 17062 - 17067]

23
[ 131-53-3 ]
7-butyl-3-methoxy-7,8-dihydro-6H-benzo[2,3]oxocino[5,4-b]benzofuran-6-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tetrahydrofuran / 3 h / 0 - 70 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine; BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾ / dichloromethane / 36 h / 24 °C / Molecular sieve; Inert atmosphere

24
[ 131-53-3 ]
[ 4301-14-8 ]
C₁₆H₁₄O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	In tetrahydrofuran at 0 - 70℃; for 3h; Inert atmosphere;

25
[ 131-53-3 ]
methyl 3-Methoxy-12H-dibenzo[d,g][1,3]dioxocin-6-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: potassium iodide; potassium carbonate / water; ethyl acetate; isopropyl alcohol 2: methanol; hexane 3: hydrogen; acetic acid / palladium / ethanol; hexane; water; ethyl acetate

Reference： [1]Current Patent Assignee: DOW INC - US4979978, 1990, A

26
[ 131-53-3 ]
[ 133704-96-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: potassium iodide; potassium carbonate / water; ethyl acetate; isopropyl alcohol 2: methanol; hexane 3: hydrogen; acetic acid / palladium / ethanol; hexane; water; ethyl acetate 4: sodium hydroxide / tetrahydrofuran; water

Reference： [1]Current Patent Assignee: DOW INC - US4979978, 1990, A

27
[ 131-53-3 ]
[ 133704-94-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium iodide; potassium carbonate / water; ethyl acetate; isopropyl alcohol 2: methanol; hexane

Reference： [1]Current Patent Assignee: DOW INC - US4979978, 1990, A

28
[ 131-53-3 ]
[ 13087-18-8 ]
[ 7392-62-3 ]

Yield	Reaction Conditions	Operation in experiment
	With water; NADPH In aq. phosphate buffer at 37℃; for 2.5h; Microbiological reaction;

Reference： [1]Zhan, Tingjie; Zhang, Leili; Cui, Shixuan; Liu, Weiping; Zhou, Ruhong; Zhuang, Shulin [Environmental Pollution, 2021, vol. 268]

29
[ 243643-58-5 ]
[ 131-53-3 ]
C₄₂H₃₉Cl₂O₄P₂Ru [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
24%	Stage #1: (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-methanone With sodium hydroxide In methanol Stage #2: mer-[(1,4-bis(diphenylphosphino)butane)aquatrichlororuthenium(III)] In methanol

Reference： [1]Dias, Júlia Scaff Moreira; Martins, Felipe Terra; De Araújo Neto, João Honorato; Castellano, Eduardo Ernesto; Viana, Rommel Bezerra; Teixeira, Jéssica Da Silva; Guimarães, Elisalva Teixeira; Soares, Milena Botelho Pereira; Frazão Barbosa, Marília Imaculada; Doriguetto, Antônio Carlos [New Journal of Chemistry, 2021, vol. 45, # 17, p. 7501 - 7515]

30
[ 2033-24-1 ]
[ 131-53-3 ]
3-methoxy-6H,7H-chromeno[3,4-c]chromene-6,7-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With benzenesulfonic acid In para-xylene at 150℃; for 5h; Sealed tube;

Reference： [1]Wang, Ding; Ma, Zhishuang; Xi, Jin; Wang, Nana; Wang, Tao; Liang, Yong; Zhang, Zunting [European Journal of Organic Chemistry, 2022, vol. 2022, # 13]

31
[ 131-53-3 ]
[ 107-15-3 ]
[ 2888549-53-7 ]

Yield	Reaction Conditions	Operation in experiment
	In chloroform at 80℃;	4 Preparation of epoxy resin curing agent D: Add 50 g of n-propanol into a 100 mL three-necked flask, and then add 0.02 mol of 2.2'-dihydroxy-4-methoxybenzophenone and 0.01 mol of ethylenediamine respectively.Put the three-neck flask on a magnetic stirrer with a jacket, connect the stirrer, water separator and condenser, turn on the stirrer to stir, control the reaction at 80°C for 0.5h, and discharge the material to obtain a solidified epoxy resin Agent D

Reference： [1]Current Patent Assignee: WANHUA CHEMICAL GROUP CO LTD - CN115417792, 2022, A Location in patent: Paragraph 0054-0058

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P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 131-53-3 ]

Quality Control of [ 131-53-3 ]

Related Doc. of [ 131-53-3 ]

Product Details of [ 131-53-3 ]

Safety of [ 131-53-3 ]

Application In Synthesis of [ 131-53-3 ]

[ 131-53-3 ] Synthesis Path-Downstream 1~31

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry