[ CAS No. 13194-60-0 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 13194-60-0
Chemical Structure| 13194-60-0
Structure of 13194-60-0

Quality Control of [ 13194-60-0 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 13194-60-0 ]

SDS

Product Details of [ 13194-60-0 ]

CAS No. :13194-60-0MDL No. :MFCD00490146
Formula :C5H3ClN2O2Boiling Point :256°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :158.54Pubchem ID :2762909
Synonyms :

Computed Properties of [ 13194-60-0 ]

TPSA : 58.7 H-Bond Acceptor Count : 3
XLogP3 : 1.3 H-Bond Donor Count : 0
SP3 : 0.00 Rotatable Bond Count : 0

Safety of [ 13194-60-0 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 13194-60-0 ]

  • Downstream synthetic route of [ 13194-60-0 ]

[ 13194-60-0 ] Synthesis Path-Downstream   1~10

YieldReaction ConditionsOperation in experiment
When in the procedure of Example 1, equal molar amounts of the following are substituted for 2-chloro-3-nitropyridine, 2-chloro-5-methoxy-3-nitropyridine, 3-chloro-4-nitropyridine, 5-chloro-2-methoxy-4-nitropyridine, 4-chloro-3-nitropyridine, and 3-chloro-2-nitropyridine
When in accordance with the procedure of example 1, equal molar amounts of the following are substituted for 2-chloro-3-nitropyridine: 2-chloro-3-nitro-5-methoxypyridine, 3-chloro-4-nitropyridine, 2-methoxy-4-nitro-5-chloropyridine, 3-nitro-4-chloropyridine, and 2-nitro-3-chloropyridine,
  • 3
  • [ 13194-60-0 ]
  • [ 106-45-6 ]
  • 3-chloro-4-(p-tolylthio)pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% With potassium phosphate; 18-crown-6 ether; In tetrahydrofuran; at 20℃; for 3h; General procedure: In a glovebox, K3PO4 (10 mol %, 5.3 mg), 18-Crown-6 (20 mol %, 13.2 mg) , and 2.5 mL tetrahydrofuran were added into a Schlenk tube equipped with a stir bar, then thiol (0.25 mmol) and nitrobenzene derivative (0.25 mmol) were added on the outside under an air atmosphere. The reaction mixture was stirred at room temperature 3 h (450 rpm). The resultant solution was concentrated and purified by silica gel column chromatography with EtOAc and petroleum ether as the eluent to give the corresponding thioether.
  • 4
  • [ 13194-60-0 ]
  • [ 1692-15-5 ]
  • 3-(4-nitropyridin-4-yl)pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In ethanol; water; toluene; at 100℃; for 24h;Inert atmosphere; [13194-60-0]3-chloro-4-nitropyridine (5 g, 31.63 mmol), 4-pyridine boronic acid (3 g, in a 500 ml one-neck flask).37.75mmol),50 ml of a 2 M potassium carbonate aqueous solution was dissolved in 50 ml of ethanol and 100 ml of toluene in a solvent.Under the protection of N2, PdCl2(PPh3)2 (0.75 g, 0.98 mmol) was added. The temperature was slowly raised to 100 C, and the mixture was reacted under reflux for 24 h.After cooling, the layers were separated, and the organic layer was evaporated, and then, with petroleum ether and ethyl acetate (1.5:1).4.5 g of a pale yellow solid were obtained in a yield of 65%.
  • 5
  • [ 13194-60-0 ]
  • C16H10BrN3 [ No CAS ]
  • 6
  • [ 13194-60-0 ]
  • [ 244-78-0 ]
  • 7
  • [ 13194-60-0 ]
  • C16H10BrN3 [ No CAS ]
  • 8
  • [ 13194-60-0 ]
  • [ 875831-41-7 ]
  • 9
  • [ 13194-60-0 ]
  • C16H10BrN3 [ No CAS ]
  • 10
  • [ 13194-60-0 ]
  • [ 26422-85-5 ]
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