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[ CAS No. 1334336-12-7 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1334336-12-7
Chemical Structure| 1334336-12-7
Structure of 1334336-12-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1334336-12-7 ]

CAS No. :1334336-12-7 MDL No. :MFCD19688483
Formula : C11H22N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 230.30 Pubchem ID :-
Synonyms :

Safety of [ 1334336-12-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1334336-12-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1334336-12-7 ]

[ 1334336-12-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1334336-12-7 ]
  • [ 1370411-44-1 ]
  • [ 2158302-97-5 ]
YieldReaction ConditionsOperation in experiment
98% With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃; for 1h; Cooling with ice; 256.A Step A: benzyl 4-(4-(tert-butoxycarbonyl)-3-(methoxymethyl)piperazin-1-yl)-2-chloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate: A solution of tert-butyl 2- (methoxymethyl)piperazine-l-carboxylate (0.715 g, 3.10 mmol) in N,N-dimethylacetamide (3 ml) was cooled on an ice bath with stirring and solid benzyl 2,4-dichloro-5,8-dihydropyrido[3,4- d]pyrimidine-7(6H)-carboxylate (1.00 g, 2.96 mmol) was added in small portions, followed by DIPEA (0.57 mL, 3.25 mmol, 1.1 eq.). The resulting solution was allowed to warm up to r.t. over 1 hour, and then divided between water (15 mL) and MTBE (50 mL). The organic layer was washed with water (2 x 10 mL), brine (10 mL), dried over Na2S04 and evaporated in vacuo to give a yellow solid (1.54 g, 98%). ES+APCI MS m/z 532.3, [M+H]+.
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