Alternatived Products of [ 1334336-12-7 ]
Product Details of [ 1334336-12-7 ]
CAS No. : | 1334336-12-7 |
MDL No. : | MFCD19688483 |
Formula : |
C11H22N2O3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
230.30
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 1334336-12-7 ]
Application In Synthesis of [ 1334336-12-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1334336-12-7 ]
- 1
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[ 1334336-12-7 ]
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[ 1370411-44-1 ]
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[ 2158302-97-5 ]
Yield | Reaction Conditions | Operation in experiment |
98% |
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃; for 1h; Cooling with ice; |
256.A Step A: benzyl 4-(4-(tert-butoxycarbonyl)-3-(methoxymethyl)piperazin-1-yl)-2-chloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate:
A solution of tert-butyl 2- (methoxymethyl)piperazine-l-carboxylate (0.715 g, 3.10 mmol) in N,N-dimethylacetamide (3 ml) was cooled on an ice bath with stirring and solid benzyl 2,4-dichloro-5,8-dihydropyrido[3,4- d]pyrimidine-7(6H)-carboxylate (1.00 g, 2.96 mmol) was added in small portions, followed by DIPEA (0.57 mL, 3.25 mmol, 1.1 eq.). The resulting solution was allowed to warm up to r.t. over 1 hour, and then divided between water (15 mL) and MTBE (50 mL). The organic layer was washed with water (2 x 10 mL), brine (10 mL), dried over Na2S04 and evaporated in vacuo to give a yellow solid (1.54 g, 98%). ES+APCI MS m/z 532.3, [M+H]+. |