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Chemical Structure| 1338824-20-6 Chemical Structure| 1338824-20-6

Structure of NCGC00229600
CAS No.: 1338824-20-6

Chemical Structure| 1338824-20-6

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NCGC00229600 is an allosteric inverse agonist of TSHR that can inhibit TSH and antibody activation of TSHRs in Graves' disease.

Synonyms: NCGC00229600

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Product Details of NCGC00229600

CAS No. :1338824-20-6
Formula : C30H29N3O3
M.W : 479.57
SMILES Code : O=C1N(CC2=CC=CN=C2)C(C3=CC=C(OC)C(COC4=C(C)C=CC=C4C)=C3)NC5=C1C=CC=C5
Synonyms :
NCGC00229600
MDL No. :MFCD25977097
InChI Key :ODFGSMOTQLYMHU-UHFFFAOYSA-N
Pubchem ID :50897816

Safety of NCGC00229600

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of NCGC00229600

GPCR

Isoform Comparison

Biological Activity

Description
NCGC00229600 is characterized as an allosteric inverse agonist for the thyrotropin receptor (TSHR), effectively inhibiting the activation of TSHRs by both thyroid-stimulating hormone (TSH) and stimulating antibodies found in Graves' disease. This highlights its potential for therapeutic applications in treating conditions related to thyroid dysfunction[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.43mL

2.09mL

1.04mL

20.85mL

4.17mL

2.09mL

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