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Type HazMat fee for 500 gram (Estimated)
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1353979-43-7 Chemical Structure| 1353979-43-7

Structure of NMDAR/TRPM4-IN-2 free base
CAS No.: 1353979-43-7

Chemical Structure| 1353979-43-7

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NMDAR/TRPM4-IN-2 free base is an effective inhibitor of the NMDAR and TRPM4 interaction interface, with neuroprotective activity preventing NMDA-induced neuronal death and mitochondrial dysfunction, with an IC50 value of 2.1 μM.

4.5 *For Research Use Only !

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Product Details of NMDAR/TRPM4-IN-2 free base

CAS No. :1353979-43-7
Formula : C11H17BrN2
M.W : 257.17
SMILES Code : NCCN(CC1=CC=CC(Br)=C1)CC
InChI Key :XSMDMHAMGOGFLG-UHFFFAOYSA-N
Pubchem ID :66568274

Safety of NMDAR/TRPM4-IN-2 free base

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H335-H314
Precautionary Statements:P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P403+P233-P405-P501
Class:8
UN#:2735
Packing Group:

Isoform Comparison

Biological Activity

Description
NMDAR/TRPM4-IN-2 free base is a potent inhibitor of the NMDAR/TRPM4 interaction interface, showing neuroprotective effects. It prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM, and protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss [1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.89mL

0.78mL

0.39mL

19.44mL

3.89mL

1.94mL

38.88mL

7.78mL

3.89mL

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