There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 1369773-39-6 | MDL No. : | MFCD28137893 |
Formula : | C48H56CaN2O10 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | DDLCKLBRBPYKQS-OXXXZDCLSA-L |
M.W : | 861.04 | Pubchem ID : | 92045585 |
Synonyms : |
AHU-377 hemicalcium salt;AHU377 (calcium salt);Sacubitril
|
Chemical Name : | Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate |
Num. heavy atoms : | 61 |
Num. arom. heavy atoms : | 24 |
Fraction Csp3 : | 0.38 |
Num. rotatable bonds : | 26 |
Num. H-bond acceptors : | 10.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 227.67 |
TPSA : | 191.06 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.24 cm/s |
Log Po/w (iLOGP) : | -41.89 |
Log Po/w (XLOGP3) : | 7.48 |
Log Po/w (WLOGP) : | 5.0 |
Log Po/w (MLOGP) : | 4.22 |
Log Po/w (SILICOS-IT) : | 4.73 |
Consensus Log Po/w : | -4.09 |
Lipinski : | 3.0 |
Ghose : | None |
Veber : | 2.0 |
Egan : | 1.0 |
Muegge : | 4.0 |
Bioavailability Score : | 0.17 |
Log S (ESOL) : | -8.47 |
Solubility : | 0.00000294 mg/ml ; 0.0000000034 mol/l |
Class : | Poorly soluble |
Log S (Ali) : | -11.33 |
Solubility : | 0.0000000041 mg/ml ; 0.0 mol/l |
Class : | Insoluble |
Log S (SILICOS-IT) : | -6.79 |
Solubility : | 0.000141 mg/ml ; 0.000000164 mol/l |
Class : | Poorly soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 3.0 |
Synthetic accessibility : | 6.4 |
Signal Word: | Danger | Class: | 6.1 |
Precautionary Statements: | P273-P301+P310+P330 | UN#: | 2811 |
Hazard Statements: | H301-H400 | Packing Group: | Ⅲ |
GHS Pictogram: |
A269433[ 149709-62-6 ]
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
Reason: Free-salt