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[ CAS No. 1378311-80-8 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1378311-80-8
Chemical Structure| 1378311-80-8
Structure of 1378311-80-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1378311-80-8 ]

CAS No. :1378311-80-8 MDL No. :MFCD20538507
Formula : C12H14BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :268.15 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1378311-80-8 ]

[ 1378311-80-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 42287-90-1 ]
  • [ 1378311-80-8 ]
  • 2
  • [ 42287-90-1 ]
  • [ 765-30-0 ]
  • [ 1378311-80-8 ]
YieldReaction ConditionsOperation in experiment
79% Example 103 3-(3-bromophenyl)-N-cyclopropylpropanamide 3-(3-Bromophenyl) propanoic acid (3.0 g, 13.1 mmol) was added to a solution of SOC12 (10 ml) and was stirred for 2 hours at 70C. The mixture was concentrated under reduced pressure. The residue was dissolved in CH2C12 (20 ml), then was added dropwise into the mixture of cyclopropanamine (1.17g, 19.6 mmol) and triethylamine (4.0 g, 39.3 mmol) at 0 C, then the reaction mixture was stirred overnight at ambient temperature. The reaction mixture was quenched with IN HC1 and the organic layer was washed with brine, dried, concentrated to residue. The residue was purified by chromatography (PE/EA: 1/1 to 1/2) to give the title compound as white solid (2.8 g, 79 %). 1H NMR (400 MHz, CDC13) 57.36 (m, 2H), 7.15 (m, 2H), 5.53 (s, 1H), 2.94 (t, 2H), 2.68 (s, 1H), 2.41 (t, 2H), 0.77(m, 2H), 0.44 (m, 2H). m/e 268 (M+H)+.
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