Alternatived Products of [ 1380602-57-2 ]
Product Details of [ 1380602-57-2 ]
CAS No. : | 1380602-57-2 |
MDL No. : | MFCD22574091 |
Formula : |
C15H17NO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
227.30
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 1380602-57-2 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1380602-57-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1380602-57-2 ]
- 1
-
[ 529-23-7 ]
-
[ 7307-04-2 ]
-
[ 1380602-57-2 ]
Yield | Reaction Conditions | Operation in experiment |
81% |
Stage #1: o-aminobenzaldehyde; acetylpinacolin With lanthanide(III)chloride heptahydrate; acetic acid at 60℃;
Stage #2: With sodium hydroxide In water; ethyl acetate at 20℃; regioselective reaction; |
14. A typical experimental procedure.
General procedure: To a reaction vial loaded with substituted 1,3-diketone (0.24 mmol), amino benzaldehyde, (0.2 mmol) and lanthanum chloride heptahydrate was added acetic acid (3.5 mL). The resulting suspension was heated to 60 °C for 3-5 h. The reaction progress was monitored by LC-MS. At the completion, the reaction mixture was allowed to cool to room temperature. Ethyl acetate (5 mL) was added and the resulting mixture was washed with water (5 mL) and 1 N NaOH (5 mL), the organic layer was dried on MgSO4 and concentrated to give a crude product. The major quinoline product was isolated by column chromatography. |
Reference:
[1]Location in patent: experimental part
Chen, Ying; Huang, Jinkun; Hwang, Tsang-Lin; Li; Cui, Sheng; Chan, Johann; Bio, Matthew
[Tetrahedron Letters, 2012, vol. 53, # 26, p. 3237 - 3241]