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Chemical Structure| 1396777-41-5 Chemical Structure| 1396777-41-5

Structure of 1396777-41-5

Chemical Structure| 1396777-41-5

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Product Details of [ 1396777-41-5 ]

CAS No. :1396777-41-5
Formula : C9H8BrNO2
M.W : 242.07
SMILES Code : O=C1NCCOC2=CC(Br)=CC=C12
MDL No. :MFCD26900579

Safety of [ 1396777-41-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1396777-41-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1396777-41-5 ]

[ 1396777-41-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18442-22-3 ]
  • [ 1396777-41-5 ]
YieldReaction ConditionsOperation in experiment
100% A solution of <strong>[18442-22-3]7-bromochroman-4-one</strong> (340 mg, 1.5 mmol) and methanesulfonic acid (3 mL, 23.0 mmol) in DCM was cooled to 0 C. and treated with NaN3 (146 mg, 2.25 mmol) portionwise, while maintaining the internal temperature below 5 C. The reaction was then stirred at 0 C. for 4 h. At completion, the reaction was slowly neutralized with 8 N aq. NaOH, then diluted with DCM (20 mL) and water (20 mL). The layers were separated and the organics were dried over MgSO4, filtered and evaporated to afford 8-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (370 mg, 100% yield). MS (EI) m/z=242.1 [M+1]+.
 

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