140200-76-6|1,5-Dibromopentan-3-one| Ambeed

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CAS No. :	140200-76-6
Formula :	C₅H₈Br₂O
M.W :	243.92
SMILES Code :	BrCCC(=O)CCBr
MDL No. :	MFCD09833654
InChI Key :	JVWRMAONKJMECW-UHFFFAOYSA-N
Pubchem ID :	11139351

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H227-H315-H319-H335
Precautionary Statements:	P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
77%	With N-Bromosuccinimide In tetrachloromethane for 14 h; Reflux	. Synthesis of l,5-dibromopentan-3-one. (51-3) iV-Bromosuccinamide (1.70 mol) was added to a solution of l-(2- bromoethyl)cyclopropanol (1.70 mol) in carbon tetrachloride (2.50 L) and the reaction mixture was heated at reflux for 14 h. The reaction mixture was allowed to cool to rt and the insoluble solids were removed by filtration. The filtrate was washed with water (500 mL) and brine (500 mL), dried (sodium sulfate), and concentrated to provide l,5-dibromopentan-3-one in 77percent yield as a brown liquid.
68%	With N-Bromosuccinimide In tetrachloromethane at 0 - 25℃; for 16 h;	At 0° C., add N-bromosuccinimide (539 mg, 3.0 mmol) into the solution of Embodiment 71A (500 mg, 3.0 mmol) in CCl₄(8 ml). Then allow the mixture to react 16 hours at 25° C. Filter and evaporate before purify the residue with column chromatography (petroleum ether:ethyl acetate=20:1 petroleum ether:ethyl acetate=10:1) to obtain the title compound (yellow liquid, 500 mg, yield of 68percent). ¹H NMR(400 MHz,CDCl₃)3.56(t,J=6.8 Hz,2H),3.04(t,J=6.8 Hz,2H).

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CAS No.: 140200-76-6

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CAS No.: 140200-76-6

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
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H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
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