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Chemical Structure| 1402821-41-3 Chemical Structure| 1402821-41-3

Structure of GV-58
CAS No.: 1402821-41-3

Chemical Structure| 1402821-41-3

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GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 μM for N-type/P-Q-type Ca2+ channel and 20-fold less potent CDK inhibitor activity.

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Product Details of GV-58

CAS No. :1402821-41-3
Formula : C18H26N6OS
M.W : 374.50
SMILES Code : CC[C@@H](NC1=NC(NCC2=CC=C(C)S2)=C3N=CN(CCC)C3=N1)CO
MDL No. :MFCD28385865
InChI Key :DPTXJOUVBMUSGY-CYBMUJFWSA-N
Pubchem ID :71463101

Safety of GV-58

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P305+P351+P338

Isoform Comparison

Biological Activity

Description
GV-58, a new agonist for N- and P/Q-type calcium (Ca2+) channels, has EC50 values of 7.21 and 8.81 μM, respectively. It decelerates channel deactivation, leading to significantly enhanced presynaptic Ca2+ influx upon activation. GV-58 is applicable in research on Lambert-Eaton myasthenic syndrome (LEMS)[1][2][3].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.35mL

2.67mL

1.34mL

26.70mL

5.34mL

2.67mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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