[ CAS No. 14113-05-4 ] {[proInfo.proName]}

Name: 14113-05-4|(E)-10-Hydroxydec-2-enoic acid|98%
Brand: Ambeed
SKU: A370552
Price: 5.0 USD
Availability: InStock
Rating: 95 (22 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 14113-05-4

Structure of 14113-05-4 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 14113-05-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 14113-05-4 ]

SDS Specification

Alternatived Products of [ 14113-05-4 ]

Product Details of [ 14113-05-4 ]

CAS No. :	14113-05-4	MDL No. :	MFCD00204506
Formula :	C₁₀H₁₈O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QHBZHVUGQROELI-SOFGYWHQSA-N
M.W :	186.25	Pubchem ID :	5312738
Synonyms :	Queen Bee Acid;Royal Jelly acid;omega-Hydroxy C10:1(2- trans) fatty acid;10-Hydroxy-2-(E)-decenoic acid;10-HDA;10H2DA;10-Hydroxy-trans-2-decenoic acid;(E)-10-Hydroxy-2-decenoic acid	Chemical Name :	(E)-10-Hydroxydec-2-enoic acid

Calculated chemistry of [ 14113-05-4 ]

Physicochemical Properties

Num. heavy atoms :	13
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.7
Num. rotatable bonds :	8
Num. H-bond acceptors :	3.0
Num. H-bond donors :	2.0
Molar Refractivity :	52.64
TPSA :	57.53 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.9 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.1
Log Po/w (XLOGP3) :	2.16
Log Po/w (WLOGP) :	1.96
Log Po/w (MLOGP) :	1.59
Log Po/w (SILICOS-IT) :	1.91
Consensus Log Po/w :	1.95

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-1.83
Solubility :	2.77 mg/ml ; 0.0149 mol/l
Class :	Very soluble
Log S (Ali) :	-3.0
Solubility :	0.186 mg/ml ; 0.000998 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.6
Solubility :	4.65 mg/ml ; 0.0249 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	2.41

Safety of [ 14113-05-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313	UN#:	N/A
Hazard Statements:	H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 14113-05-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 14113-05-4 ]

[ 14113-05-4 ] Synthesis Path-Downstream 1~62

1
[ 186581-53-3 ]
[ 14113-05-4 ]
[ 68750-32-3 ]

Reference： [1]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1957,vol. 308,p. 284,288
[2]Tetrahedron,1961,vol. 15,p. 18 - 25

2
[ 22054-14-4 ]
[ 141-82-2 ]
[ 14113-05-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 460 - 461
[2]Chemistry of Natural Compounds,1983,vol. 19,p. 658 - 660
Khimiya Prirodnykh Soedinenii,1983,p. 695 - 698
[3]Journal of Organic Chemistry,1962,vol. 27,p. 4073 - 4076

3
[ 141-82-2 ]
[ 817-45-8 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1969,vol. 5,p. 1718 - 1721
Zhurnal Organicheskoi Khimii,1969,vol. 5,p. 1771 - 1775
[2]Journal of Organic Chemistry USSR (English Translation),1969,vol. 5,p. 1722 - 1726
Zhurnal Organicheskoi Khimii,1969,vol. 5,p. 1775 - 1779

4
[ 141-82-2 ]
Nonane-1,2,9-triol [ No CAS ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry,1962,vol. 27,p. 4073 - 4076

5
[ 92038-37-4 ]
[ 14113-05-4 ]

Reference： [1]Tetrahedron,1961,vol. 15,p. 18 - 25
[2]Tetrahedron,1961,vol. 15,p. 18 - 25

6
[ 31534-98-2 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1971,vol. 7,p. 55 - 57
Zhurnal Organicheskoi Khimii,1971,vol. 7,p. 55 - 57

7
[ 57221-93-9 ]
[ 14113-05-4 ]

Yield	Reaction Conditions	Operation in experiment
83%	With potassium hydroxide; water; In ethanol; for 8h;	119.6 g (0.56 mol) of hydroxyester was dissolved in 600 ml of ethanol and 400 ml of a 4.6 N solution of KOH was added. The medium was agitated for 8 h. The medium was extracted with isopropyl ether. The aqueous phase was acidified to pH=1 and extracted with ethyl acetate. After drying and evaporation, 99.6 g of pink solids were obtained. The solids were recrystallized in an isopropyl ether/petroleum ether mixture. The product was obtained in the form of a white solid (86 g, 83%). [0075] Characterization [0076] TLC: Rf=0.2 (heptane/ethyl acetate 7/3) [0077] Melting point: mp=61.3 C. [0078] 1H NMR (400 MHz, CDCl3): 7.06 (dt, 1H, J=15.6 and 7 Hz); 5.81 (dt, 1H, J=1.5 and 15.6 Hz); 3.64 (t, 2H, J=6.6 Hz); 2.22 (dq, 2H, J=1.2 and 7.3 Hz); 1.52-1.58 (m, 2H); 1.45-1.48 (m, 2H); 1.33-1.3765 (m, 6H).

Reference： [1]Patent: US2004/204596,2004,A1 .Location in patent: Page 5-6
[2]Bulletin of the Chemical Society of Japan,1984,vol. 57,p. 426 - 434
[3]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1992,vol. 31,p. 257 - 259
[4]Bulletin of the Chemical Society of Japan,1977,vol. 50,p. 2507 - 2508
[5]Tetrahedron Letters,1985,vol. 26,p. 53 - 56

8
[ 92157-89-6 ]
[ 14113-05-4 ]

Reference： [1]Tetrahedron,1961,vol. 15,p. 18 - 25

9
[ 762-05-0 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry,1964,vol. 29,p. 3517 - 3520

10
Acetic acid 8,10,10,10-tetrachloro-decyl ester [ No CAS ]
[ 14113-05-4 ]

Reference： [1]Collection of Czechoslovak Chemical Communications,1966,vol. 31,p. 3765 - 3774

11
[ 186581-53-3 ]
[ 14113-05-4 ]
[ 81550-30-3 ]

Reference： [1]Chemistry Letters,1982,p. 219 - 220

12
[ 14113-05-4 ]
[ 128677-37-2 ]
[ 83637-48-3 ]
(3E,14E,25E,36E)-1,12,23,34-Tetraoxa-cyclotetratetraconta-3,14,25,36-tetraene-2,13,24,35-tetraone [ No CAS ]
C₅₀H₈₀O₁₀ [ No CAS ]

Reference： [1]Helvetica Chimica Acta,1981,vol. 64,p. 1407 - 1412

13
[ 119991-72-9 ]
[ 14113-05-4 ]

Reference： [1]Chemistry Letters,1982,p. 219 - 220

15
[ 141-82-2 ]
[ 40264-95-7 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,2002,vol. 38,p. 145 - 148

16
[ 72359-96-7 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1971,vol. 7,p. 55 - 57
Zhurnal Organicheskoi Khimii,1971,vol. 7,p. 55 - 57

17
[ 31534-97-1 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1971,vol. 7,p. 55 - 57
Zhurnal Organicheskoi Khimii,1971,vol. 7,p. 55 - 57

18
2-bromo-9-chloro-nonanoyl chloride [ No CAS ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1971,vol. 7,p. 55 - 57
Zhurnal Organicheskoi Khimii,1971,vol. 7,p. 55 - 57

19
[ 26385-59-1 ]
[ 14113-05-4 ]

20
[ 26385-57-9 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1969,vol. 5,p. 1722 - 1726
Zhurnal Organicheskoi Khimii,1969,vol. 5,p. 1775 - 1779

21
[ 26511-33-1 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1969,vol. 5,p. 1722 - 1726
Zhurnal Organicheskoi Khimii,1969,vol. 5,p. 1775 - 1779

22
(2E,4E)-8,8-Diethoxy-octa-2,4-dienoic acid ethyl ester [ No CAS ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1969,vol. 5,p. 1718 - 1721
Zhurnal Organicheskoi Khimii,1969,vol. 5,p. 1771 - 1775

23
1,9-diacetoxynon-1-ene [ No CAS ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,2002,vol. 38,p. 145 - 148

24
[ 931-88-4 ]
hydrogen [ No CAS ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,1983,vol. 19,p. 658 - 660
Khimiya Prirodnykh Soedinenii,1983,p. 695 - 698

25
[ 90661-18-0 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,1983,vol. 19,p. 658 - 660
Khimiya Prirodnykh Soedinenii,1983,p. 695 - 698

26
[ 929-48-6 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,1983,vol. 19,p. 658 - 660
Khimiya Prirodnykh Soedinenii,1983,p. 695 - 698

27
[ 65157-89-3 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,1983,vol. 19,p. 658 - 660
Khimiya Prirodnykh Soedinenii,1983,p. 695 - 698

28
[ 80685-82-1 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,1983,vol. 19,p. 658 - 660
Khimiya Prirodnykh Soedinenii,1983,p. 695 - 698

29
[ 57221-80-4 ]
[ 14113-05-4 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1984,vol. 57,p. 426 - 434

30
[ 57221-92-8 ]
[ 14113-05-4 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1984,vol. 57,p. 426 - 434

31
[ 21573-31-9 ]
[ 14113-05-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1992,vol. 31,p. 257 - 259

32
[ 78426-45-6 ]
[ 14113-05-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1992,vol. 31,p. 257 - 259

33
[ 13129-60-7 ]
[ 14113-05-4 ]

Reference： [1]Chemistry Letters,1982,p. 219 - 220

34
[ 5259-98-3 ]
[ 14113-05-4 ]

Reference： [1]Chemistry Letters,1982,p. 219 - 220

35
[ 67818-20-6 ]
[ 14113-05-4 ]

Reference： [1]Chemistry Letters,1982,p. 219 - 220

36
[ 817-45-8 ]
[ 14113-05-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 460 - 461

37
[ 93176-12-6 ]
[ 14113-05-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 460 - 461

38
[ 22054-14-4 ]
[ 14113-05-4 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 53 - 56

39
[ 5698-29-3 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry,1964,vol. 29,p. 3517 - 3520

40
[ 871-66-9 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry,1964,vol. 29,p. 3517 - 3520

41
[ 762-38-9 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry,1964,vol. 29,p. 3517 - 3520

42
[ 763-53-1 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry,1964,vol. 29,p. 3517 - 3520

43
[ 819-99-8 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organic Chemistry,1964,vol. 29,p. 3517 - 3520

44
[ 3639-35-8 ]
[ 14113-05-4 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1977,vol. 50,p. 2507 - 2508

45
[ 25017-00-9 ]
[ 14113-05-4 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1977,vol. 50,p. 2507 - 2508

46
[ 64971-10-4 ]
[ 14113-05-4 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1977,vol. 50,p. 2507 - 2508

47
[ 64971-11-5 ]
[ 14113-05-4 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1977,vol. 50,p. 2507 - 2508

48
[ 110-87-2 ]
[ 14113-05-4 ]
C₁₅H₂₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In tetrahydrofuran; for 24h;	86 g (0.46 mol) of hydroxy acid was put in solution with 45 ml (0.48 mol) of 3,4-dihydro-2H-pyran in 500 ml of THF. 1 ml of concentrated HCl was added and the medium agitated for 24 h. [0081] The THF was then concentrated, the crude product was taken up with ethyl acetate and washed with a saturated solution of NaCl until neutral pH. After drying over MgSO4, 132 g of crude product was obtained (>100%). [0082] Characterization [0083] TLC: Rf=0.4 (heptane/ethyl acetate 7/3) [0084] 1H NMR (400 MHz, CDCl3): 7.06 (dt, 1H, J=15.6 and 7 Hz); 5.81 (dd, 1H, J=1.6 and 15.6 Hz); 4.58 (t, 1H, J=2.8 Hz); 3.82-3.91 (m, 1H); 3.71-3.73 (m, 1H); 3.51-3.52 (m, 1H); 3.36-3.69 (m, 1H); 2.20 (m, 2H); 1.33-1.89 (m, 16H).

Reference： [1]Patent: US2004/204596,2004,A1 .Location in patent: Page 6

49
copper (II) chloride CuCl₂ [ No CAS ]
lithium chloride LiCl [ No CAS ]
[ 28077-72-7 ]
[ 676-58-4 ]
[ 541-41-3 ]
[ 18244-15-0 ]
[ 14113-05-4 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonium chloride; In tetrahydrofuran;	EXAMPLE 6 Ethyl 10-hydroxy-2-decynate was synthesised in the following manner. Thus, 132 g (0.9 mole) of 5-bromo-1-pentyne were added dropwise at 50 to 55 C. to a solution of 1.0 mole of methyl magnesium chloride in 300 ml of tetrahydrofuran and the mixture was agitated for 1 hour at 60 C. followed by the addition of a solution of 1.0 g of lithium chloride LiCl and 1.5 g of copper (II) chloride CuCl2 dissolved in 10 ml of tetrahydrofuran. Thereafter, a solution of 1.0 mole of 4-trimethylsilyloxy butyl magnesium chloride in 300 ml of tetrahydrofuran was added dropwise at 45 to 55 C. to the reaction mixture which was agitated fro 4 hours at 40 C. In the next place, 108.5 g (1.0 mole) of ethyl chlorocarbonate were added dropwise at 10 to 20 C. to the reaction mixture which was agitated for 1 hour at 20 C. The reaction mixture was then admixed with 500 ml of a 5M aqueous solution of ammonium chloride to hydrolyze the reaction product followed by phase separation to discard the aqueous phase. The organic solution thus obtained was washed with water and subjected to purification by the column chromatography to give 129 g of a fraction which could be identified to be the desired ethyl 10-hydroxy-2-decynate. The yield of the product coresponded to 61% of the theoretical value. The above prepared ethyl 10-hydroxy-2-decynate was used as an intermediate for the synthesis of 10-hydroxy-E-2-decenoic acid in the following manner.

Reference： [1]Patent: US5082961,1992,A

50
[ 172759-80-7 ]
[ 14113-05-4 ]

Reference： [1]Journal of Organometallic Chemistry,2010,vol. 695,p. 2354 - 2358

51
[ 629-41-4 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,2014,vol. 50,p. 399 - 401
Khim. Prir. Soedin.,2014,p. 347 - 348,3
[2]Patent: CN108821964,2018,A

52
[ 40646-17-1 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,2014,vol. 50,p. 399 - 401
Khim. Prir. Soedin.,2014,p. 347 - 348,3

53
[ 1338457-45-6 ]
[ 14113-05-4 ]

Reference： [1]Chemistry of Natural Compounds,2014,vol. 50,p. 399 - 401
Khim. Prir. Soedin.,2014,p. 347 - 348,3

54
[ 14113-05-4 ]
5-fluoro-3-{(8E)-10-oxo-10-[(2,5-dioxopyrrolidin-1-yl)oxy]dec-8-en-1-yl}-2',3'-O-(1-propylbutylidene)uridine [ No CAS ]

Reference： [1]Chemistry and biodiversity,2015,vol. 12,p. 1307 - 1312

55
[ 14113-05-4 ]
5-fluoro-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]-3-{(8E)-10-oxo-10-[(2,5-dioxopyrrolidin-1-yl)oxy]dec-8-en-1-yl}-2',3'-O-(1-propylbutylidene)uridine [ No CAS ]

Reference： [1]Chemistry and biodiversity,2015,vol. 12,p. 1307 - 1312

56
[ 6066-82-6 ]
[ 14113-05-4 ]
1-[(2E)-10-Hydroxydec-2-enoyl]oxy}pyrrolidine-2,5-dione [ No CAS ]

Reference： [1]Chemistry and biodiversity,2015,vol. 12,p. 1307 - 1312

57
[ 14113-05-4 ]
[ 108-24-7 ]
[ 68750-29-8 ]

Yield	Reaction Conditions	Operation in experiment
97.6%	at 60 - 80℃; for 3h;	The royal jelly acid 93.1g, 61.5g of acetic anhydride molar ratio of 1: 1.2 mixing, stirring at 60 ~ 80 for 3 hours, after cooling to 0 ~ 15 0 ~ 15 poured into water, separation of the oil, water washed 3 times, and dried to give 113.2g product in 20 ~ 50 , yield 97.6%, HPLC content detecting ?98.5%.

Reference： [1]Patent: CN103787879,2016,B .Location in patent: Paragraph 0038-0039

58
[ 14113-05-4 ]
[ 123-62-6 ]
(E)-10-propionyloxy-2-decenoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96.1%	at 60 - 80℃; for 3h;	The royal jelly acid 93.1g, 70.0g of propionic anhydride molar ratio of 1: 1.2 mixing, stirring at 60 ~ 80 for 3 hours, after cooling to 0 ~ 15 0 ~ 15 poured into water, separation of the oil, water washed 3 times, and dried to give 114.6g product in 20 ~ 50 , yield 96.1%, HPLC content detecting ?98.0%.

Reference： [1]Patent: CN103787879,2016,B .Location in patent: Paragraph 0042-0043

59
[ 14113-05-4 ]
[ 141-43-5 ]
(E)-10-hydroxy-2-decenylethanolamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
56.5 g		To yield 46.6 g of royal jelly acid, petroleum ether 200ml, methanol 100g, 1ml of concentrated sulfuric acid in the reaction flask was heated to 65 deg.] C was stirred at reflux for 5 hours, ethanolamine was added dropwise, heated to 65 stirred at reflux for 3 hours, cooled to -5 ~ 10 deg.] C, filtered, washed three times with water, and dried to give E-10- hydroxy-2-decenyl-ethanol amide 56.5g at 50

Reference： [1]Patent: CN103787879,2016,B .Location in patent: Paragraph 0047 - 0049

60
[ 141-82-2 ]
8-cyclohexyloxyoctyl aldehyde [ No CAS ]
[ 14113-05-4 ]

Yield	Reaction Conditions	Operation in experiment
	With piperidine; piperazine; acetic acid; In 1,3,5-trimethyl-benzene; at 70℃; for 8h;	According to the ratio of raw materials,That is, the amount of mesitylene is 0.25 ml (based on the molar amount of malonic acid of 1 mmol).Piperidine is used in an amount of 0.2 mol%(based on 100 mol% of the number of moles of 8-cyclohexyloxyoctyl aldehyde).In a three-necked flask, add mesitylene, 8-cyclohexyloxyoctyl aldehyde,Piperazine and the right amount of acetic acid,Control the temperature to 70 C for 8 h and then stop the reaction.And detected by TLC, after the reaction is completed, the solvent is thawed,Acidified to pH = 3 with hydrochloric acid and extracted with diethyl ether.Combine the extract. The organic phase is back-extracted with 5% by mass NaOH solution.The aqueous layer was separated to remove the dissolved diethyl ether under reduced pressure, and then acidified and extracted with diethyl ether.The organic phase is dried to remove the solvent to give a crude material. The crude material is recrystallized from petroleum ether to give the royal jelly acid.The total yield in this example was tested to be 86.8%.

Reference： [1]Patent: CN108821964,2018,A .Location in patent: Paragraph 0023; 0026; 0029; 0032; 0035

61
[ 68750-32-3 ]
[ 14113-05-4 ]

Yield	Reaction Conditions	Operation in experiment
97%	With sodium hydroxide; at 20℃; for 4h;	9.6 g (0.049 mol) of the compound III prepared above, 12.9 mL of 20 wt% NaOH (0.079 mol) was added to a 100 mL one-neck flask, and the reaction was stirred at room temperature for 4 h;After the reaction is completed, the mixture is added dropwise with concentrated hydrochloric acid under an ice bath, and the pH of the solution is adjusted to 3 to 4, and it is placed in a refrigerator overnight to be crystallized, and filtered to obtain a crude product.The crude product was recrystallized from a volume ratio of 1:1 petroleum ether and diethyl ether mixed solvent.Obtained 8.84 g of white solid royal jelly acid, 97% yield

Reference： [1]Patent: CN109942397,2019,A .Location in patent: Page/Page column 4-6

62
[ 10160-24-4 ]
[ 14113-05-4 ]

Reference： [1]Patent: CN109942397,2019,A

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 14113-05-4 ]

Alkenes

[ 13419-69-7 ]

trans-Hex-2-enoic acid

Similarity: 0.91

[ 56453-86-2 ]

(E)-3-Cyclohexylacrylic acid

Similarity: 0.85

[ 111-79-5 ]

Methyl non-2-enoate

Similarity: 0.79

[ 2396-77-2 ]

Methyl 2-Hexenoate

Similarity: 0.75

[ 541-47-9 ]

3-Methylbut-2-enoic acid

Similarity: 0.72

Aliphatic Chain Hydrocarbons

[ 13419-69-7 ]

trans-Hex-2-enoic acid

Similarity: 0.91

[ 111-79-5 ]

Methyl non-2-enoate

Similarity: 0.79

[ 2396-77-2 ]

Methyl 2-Hexenoate

Similarity: 0.75

[ 541-47-9 ]

3-Methylbut-2-enoic acid

Similarity: 0.72

[ N/A ]

Sodium 2-octadecylfumarate

Similarity: 0.72

Carboxylic Acids

[ 13419-69-7 ]

trans-Hex-2-enoic acid

Similarity: 0.91

[ 56453-86-2 ]

(E)-3-Cyclohexylacrylic acid

Similarity: 0.85

[ 541-47-9 ]

3-Methylbut-2-enoic acid

Similarity: 0.72

[ 636-82-8 ]

Cyclohex-1-enecarboxylic acid

Similarity: 0.72

[ 1560-11-8 ]

1-Cyclopentenecarboxylic acid

Similarity: 0.72

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 14113-05-4 ] {[proInfo.proName]}

Quality Control of [ 14113-05-4 ]

Related Doc. of [ 14113-05-4 ]

Product Details of [ 14113-05-4 ]

Calculated chemistry of [ 14113-05-4 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 14113-05-4 ]

Application In Synthesis of [ 14113-05-4 ]

[ 14113-05-4 ] Synthesis Path-Downstream 1~62

Related Functional Groups of [ 14113-05-4 ]

Alkenes

Aliphatic Chain Hydrocarbons

Carboxylic Acids

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 14113-05-4 ]