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[ CAS No. 1414938-21-8 ] {[proInfo.proName]}

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Chemical Structure| 1414938-21-8
Chemical Structure| 1414938-21-8
Structure of 1414938-21-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1414938-21-8 ]

CAS No. :1414938-21-8 MDL No. :N/A
Formula : C27H23F3N6O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 504.51 Pubchem ID :-
Synonyms :
Chemical Name :1-(4-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea

Safety of [ 1414938-21-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 UN#:N/A
Hazard Statements:H315-H319-H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1414938-21-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1414938-21-8 ]

[ 1414938-21-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1320266-94-1 ]
  • 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene-1-yl)-3-(3-(trifluoromethyl)phenyl)urea [ No CAS ]
  • [ 1414938-21-8 ]
YieldReaction ConditionsOperation in experiment
61% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In water; N,N-dimethyl-formamide; at 85.0℃; 1 -(4-(8-amino-3 -isopropylimidazo[ 1 ,5-a]pyrazin- 1 -yl)naphthalen- 1 -yl)-3 -(3- (trifluoromethyl)phenyl)urea (KIRA3). A mixture of compound 1 (12.0 mg, 0.040 mmol), compound 3 (21.9 mg, 0.048 mmol), tetrakis(triphenylphosphine)palladium (1.4 mg, 1.2 muetaiotaomicroniota) and sodium carbonate (9.3 mg, 0.088 mmol) was dissolved in a 3 : 1 mixture of DME/water (160 uL). The mixture was heated overnight at 85 C. The crude mixture was cooled to room temperature, diluted in a mixture of acetonitrile/water and purified by reverse phase chromatography (HPLC) to obtain 12.3 mg of GP146 (61% yield). TLC (CH2C12:MeOH, 95:5 v/v): Rf = 0.4; 1H MR (300 MHz, MeOD): delta 8.27-8.22 (m, 1H), 8.02-7.96 (m, 2H), 7.90-7.86 (m, 1H), 7.83-7.79 (m, 1H), 7.72-7.49 (m, 5H), 7.37-7.32 (m, 1H), 7.04-6.99 (m, 1H), 3.66-3.55 (m, 1H), 1.54-1.48 (m, 6H); 13C NMR (500 MHz, MeOD): delta 154.9, 151.6, 149.8, 140.2, 135.9, 132.9, 129.4, 128.7, 128.7, 127.1, 126.6, 126.6, 125.8, 125.7, 121.9, 121.9, 121.8, 120.2, 1 18.7, 118.7, 1 15.1, 1 14.6, 1 12.9, 108.4, 25.8, 19.6; [M+l]+ found, 505.4. HPLC Purification Conditions: C18 column (250 x 21 mm), CH3CN/H2O-0.1% CF3C02H = 1 :99 to 100:0 over 78 min; 8 mL/min; 220 nm and 254 nm detection for 78 min. The purity of GP146 was determined to be >98% by analytical HPLC in two different solvent systems.
  • 2
  • [ 1218790-22-7 ]
  • [ 1414938-21-8 ]
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