Home Cart Sign in  
Chemical Structure| 1422365-93-2 Chemical Structure| 1422365-93-2

Structure of Lixumistat
CAS No.: 1422365-93-2

Chemical Structure| 1422365-93-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

IM156 is a metformin derivative which has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin. IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses. IM156 activated AMPK in a dose-dependent manner, and produced shortening of the circadian period and enhanced degradation of the clock genes PER2 and CRY1.

Synonyms: IM156 free base; HL156A free base; HL156A

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Lixumistat

CAS No. :1422365-93-2
Formula : C13H16F3N5O
M.W : 315.29
SMILES Code : N=C(N1CCCC1)NC(NC2=CC=C(OC(F)(F)F)C=C2)=N
Synonyms :
IM156 free base; HL156A free base; HL156A
MDL No. :MFCD32856762
InChI Key :NGFUHJWVBKTNOE-UHFFFAOYSA-N
Pubchem ID :71512108

Safety of Lixumistat

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of Lixumistat

epigenetics
PI3K-AKT

Isoform Comparison

Biological Activity

Description
Lixumistat (IM156) is a newly developed biguanide mitochondrial protein complex 1 inhibitor targeting oxidative phosphorylation (OXPHOS), displaying anti-tumor effects. Lixumistat modulates OXPHOS to mitigate mitochondrial metabolic reprogramming and suppress lung fibrosis. Additionally, Lixumistat inhibits B-cell activation, thereby alleviating symptoms of systemic lupus erythematosus [1][5].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.17mL

0.63mL

0.32mL

15.86mL

3.17mL

1.59mL

31.72mL

6.34mL

3.17mL

 

Historical Records

Categories