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Chemical Structure| 142880-36-2 Chemical Structure| 142880-36-2

Structure of Ilomastat
CAS No.: 142880-36-2

Chemical Structure| 142880-36-2

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Ilomastat (GM6001) is a potent broad-spectrum matrix metalloprotease (MMP) inhibitor, with IC50 values of 1.5 nM for MMP-1, 1.1 nM for MMP-2, 1.9 nM for MMP-3, and 0.5 nM for MMP-9, and a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).

Synonyms: GM6001; Galardin

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Product Details of Ilomastat

CAS No. :142880-36-2
Formula : C20H28N4O4
M.W : 388.46
SMILES Code : O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(NC)=O)[C@H](CC(C)C)CC(NO)=O
Synonyms :
GM6001; Galardin
MDL No. :MFCD00917040
InChI Key :NITYDPDXAAFEIT-DYVFJYSZSA-N
Pubchem ID :132519

Safety of Ilomastat

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • MMP

    MMP-26, Ki:0.36 nM

    MMP-2, Ki:0.1 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03297827 - Recruiting August 27, 2019 United States, New Mexico ... More >> Department of Neurology, University of New Mexico Recruiting Albuquerque, New Mexico, United States, 87131-0007 Contact: Asad Ikram, MD    505-272-9382    aikram@salud.unm.edu    Principal Investigator: Atif Zafar, MD          Sub-Investigator: Asad Ikram, MD Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.87mL

2.57mL

1.29mL

25.74mL

5.15mL

2.57mL

References

 

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