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Inhibitors/Agonists
Protein Tyrosine Kinase/RTK
EGFR
Poziotinib hydrochloride
Inhibitors/Agonists
Protein Tyrosine Kinase/RTK
EGFR

[ CAS No. 1429757-68-5 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1429757-68-5
Chemical Structure| 1429757-68-5
Structure of 1429757-68-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1429757-68-5 ]

CAS No. :1429757-68-5 MDL No. :
Formula : C23H22Cl3FN4O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 527.80 Pubchem ID :-
Synonyms :

Safety of [ 1429757-68-5 ]

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Precautionary Statements: UN#:
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Application In Synthesis of [ 1429757-68-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1429757-68-5 ]

[ 1429757-68-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1092364-38-9 ]
  • [ 1429757-68-5 ]
YieldReaction ConditionsOperation in experiment
81% With hydrogenchloride; In methanol; water; for 24.0h; Example 6 Preparation of <strong>[1092364-38-9]1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one</strong> hydrochloride (the Compound of Formula (I)) 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidine-1-yl)prop-2-en-1-one (150 g) was added to methanol (700 ml). Hydrochloric acid (38.2 ml) diluted with methanol (300 ml) was added thereto, followed by stirring for 24 hours. The solid thus obtained was filtered and washed with acetone (100 ml). The resulting solid was dried at 40 C. in an oven for 24 hours to produce the compound of formula (I) (131 g, yield: 81%). 1H-NMR (DMSO-d6, 300 MHz, ppm) delta12.31 (bs, 1H), 8.83 (s, 1H), 8.67 (s, 1H), 7.64-7.55 (m, 2H), 7.39 (s, 1H), 6.87-6.78 (m, 1H), 6.12-6.06 (m, 1H), 5.68-5.64 (m, 1H), 5.07-5.01 (m, 1H), 4.06-3.88 (m, 5H), 3.51 (t, 1H), 3.32 (t, 1H), 2.10 (t, 1H), 1.60 (t, 1H).
Reference： [1]Patent: US2014/275534,2014,A1 .Location in patent: Paragraph 0058; 0059; 0060
  • 2
  • [ 886762-39-6 ]
  • [ 1429757-68-5 ]
Reference： [1]Patent: US2014/275534,2014,A1
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[ 1429757-68-5 ]

Chemical Structure| 1092364-38-9

A719269[ 1092364-38-9 ]

1-(4-((4-((3,4-Dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one

Reason: Free-salt