Alternatived Products of [ 1431869-27-0 ]
Product Details of [ 1431869-27-0 ]
CAS No. : | 1431869-27-0 |
MDL No. : | MFCD27922917 |
Formula : |
C10H5ClN2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
188.61
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1431869-27-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1431869-27-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1431869-27-0 ]
- 1
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[ 84973-05-7 ]
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copper(l) cyanide
[ No CAS ]
-
[ 1431869-27-0 ]
Yield | Reaction Conditions | Operation in experiment |
|
In N,N-dimethyl-formamide at 150℃; |
9.A Step A: 7-chloroquinoline-3-carbonitrile
Step A: 7-chloroquinoline-3-carbonitrile: To a flask containing a stir bar was added 3-bromo-7- chloroquinoline (1.0 g, 4.1 mmol), CuCN (0.55 g, 6.2 mmol) followed by addition of DMF (25 mL). The resulting mixture was then heated to 150 °C overnight. When the reaction was complete as evidenced by LC analyisis, the reaction flask was taken out of the oil bath and cooled to RT. To the reaction mixture was then poured DCM (20 mL) and a precipitate formed immediately, which was filtered. The filtrated was washed with aq. NH4CI, dried over sodium sulfate, and purified by flash chromatography. LC-MS (IE, m/z) 189 [M + 1]+. |