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Chemical Structure| 1431980-60-7 Chemical Structure| 1431980-60-7

Structure of TASP0433864
CAS No.: 1431980-60-7

Chemical Structure| 1431980-60-7

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TASP0433864 is a novel positive allosteric modulator of metabotropic glutamate 2 receptor. TASP0433864 exhibited PAM activity at human and rat mGlu2 receptors with EC50 values of 199 and 206 nM, respectively, without exerting agonist activity at rat mGlu2 receptor. TASP0433864 produced a leftward and upward shift in the concentration-response curve of glutamate-increased guanosine 5'-O-(3-[(35)S]thio)triphosphate binding to mGlu2 receptor. The inhibitory effect of TASP0433864 on cortical activation was also observed in the mouse 2-deoxy-glucose uptake study. TASP0433864 is a selective mGlu2 receptor PAM with antipsychotic activity, and the attenuation of excess glutamatergic neurotransmission may be involved in the action of TASP0433864.

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Product Details of TASP0433864

CAS No. :1431980-60-7
Formula : C18H23N3O3
M.W : 329.39
SMILES Code : O=C(C1=C(C)N2C(O[C@H](COC3=CC=C(C(C)(C)C)C=C3)C2)=N1)N
MDL No. :MFCD30720884

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3.04mL

0.61mL

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15.18mL

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1.52mL

30.36mL

6.07mL

3.04mL

 

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