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[ CAS No. 1448902-18-8 ]

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Chemical Structure| 1448902-18-8
Chemical Structure| 1448902-18-8
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Product Details of [ 1448902-18-8 ]

CAS No. :1448902-18-8 MDL No. :MFCD12756984
Formula : C9H13Cl2N Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :206.11 g/mol Pubchem ID :53484804
Synonyms :

Safety of [ 1448902-18-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1448902-18-8 ]

  • Upstream synthesis route of [ 1448902-18-8 ]
  • Downstream synthetic route of [ 1448902-18-8 ]

[ 1448902-18-8 ] Synthesis Path-Upstream   1~2

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  • [ 1448902-54-2 ]
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YieldReaction ConditionsOperation in experiment
59% With hydrogenchloride In 1,4-dioxane; methanol at 20℃; for 0.666667 h; General procedure: 4N-HCl in 1,4-dioxane (3.60mL, 14.4mmol) was added to a solution of 40a (1.93g, 7.22mmol) in methanol (3.60mL) at room temperature, and the mixture was stirred at the same temperature for 40min. Et2O was added to the reaction mixture, and then the precipitate was collected by filtration to obtain 29a (1.30g, 90percent) as a colorless solid. 1H NMR (500MHz, CD3OD): δ 7.49–7.41 (m, 5H), 4.31 (dd, J=10.0, 5.6Hz, 1H), 1.93 (ddd, J=15.6, 10.3, 5.4Hz, 1H), 1.81–1.75 (m, 1H), 1.44–1.36 (m, 1H), 0.96 (d, J=6.8Hz, 3H), 0.92 (d, J=6.8Hz, 3H).
Reference: [1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 18, p. 5907 - 5922
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Reference: [1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 18, p. 5907 - 5922
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