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Chemical Structure| 1449430-45-8 Chemical Structure| 1449430-45-8

Structure of 1449430-45-8

Chemical Structure| 1449430-45-8

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Product Details of [ 1449430-45-8 ]

CAS No. :1449430-45-8
Formula : C14H8ClFN4O3
M.W : 334.69
SMILES Code : OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1[N+]([O-])=O
English Name :4-((3-Chloro-4-fluorophenyl)amino)-6-nitroquinazolin-7-ol

Safety of [ 1449430-45-8 ]

Application In Synthesis of [ 1449430-45-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1449430-45-8 ]

[ 1449430-45-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 26040-62-0 ]
  • [ 1449430-45-8 ]
  • [ 1619241-72-3 ]
YieldReaction ConditionsOperation in experiment
70% With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 24h; 1.3 (3) 7-(4-(3-chloro-4-fluorophenyl)-6-nitro-quinazolin-7-yloxy)heptanoic acid methyl ester Preparation (3) 7-(4-(3-chloro-4-fluorophenyl)-6-nitro-quinazolin-7-yloxy)heptanoic acid methyl ester Preparation 4- (3-chloro-4-fluorophenyl) -6-nitroquinazolin-7-ol (10g, 30mmol) was dissolved in DMF (60mL) , 7-chloroheptanoic acid methyl ester (8g, 45mmol) and K2CO3 (12g, 90mmol) was added,the reaction was heated to 90 deg°C for 24 hours, the reaction mixture was added 150mL of water, and filtered to give the desired product (10g, 70%).
  • 2
  • [ 1449430-45-8 ]
  • [ 86087-23-2 ]
  • [ 314771-88-5 ]
YieldReaction ConditionsOperation in experiment
89% With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 10 - 20℃; for 0.5h; 7 Embodiment 7Preparation of compound VI Compound IV 24.5g, S-3-hydroxy tetrahydrofuran (V) 6.4g, triphenylphosphine 19.1g, 1800 ml tetrahydrofuran is added to the reaction flask, stirring to dissolve, in the ice, maintaining 10 °C the following slow dropwise containing azo dicarboxylic acid diethyl ester 25.4g tetrahydrofuran solution of 500 ml, completion of the dropping, 10 °C lower heat insulating reaction 30 min, then to rise to room temperature, TLC showed the disappearance of the raw materials, the reaction liquid soluble turns on lathe does, remainder silica gel column chromatography to obtain the solid 26.6g, molar yield 89%, HPLC purity 98.8%.
  • 3
  • [ 1449430-45-8 ]
  • [ 125422-83-5 ]
  • [ 267243-64-1 ]
YieldReaction ConditionsOperation in experiment
91.8% With potassium carbonate In acetonitrile at 50 - 55℃; 3 Example three: At room temperature, 4-(3-bromopropyl)-morpholine (6.24 g, 30 mmol) and solvent acetonitrile 100 mL were added to the reaction flask, and potassium carbonate (4.14 g, 30 mmol) was added with stirring until all were dissolved. Warm to 50-55°C and add 7-hydroxy-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine (V) (3.34g, 10mmol) with stirring, continue The reaction was stirred for 6-8 hours, and the reaction was completed by TLC. Cool to room temperature, add water and adjust the pH to neutral with dilute hydrochloric acid, solid precipitates, crystallize slowly at 05 for 2-3 hours, filter with suction and dry under reduced pressure to obtain N-(3-chloro-4-fluorophenyl )-7-(3-morpholin-4-propoxy)-6-nitroquinazolin-4-amine (III) 4.23g, yield 91.8%.
 

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