[ CAS No. 14568-68-4 ] {[proInfo.proName]}

Name: 14568-68-4|Benzene, 2-ethenyl-1,4-dimethoxy-|95%
Brand: Ambeed
SKU: A989922
Rating: 98 (22 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 14568-68-4

Structure of 14568-68-4 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 14568-68-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 14568-68-4 ]

SDS Specification

Alternatived Products of [ 14568-68-4 ]

Product Details of [ 14568-68-4 ]

CAS No. :	14568-68-4	MDL No. :	MFCD16883101
Formula :	C₁₀H₁₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	HBZNAZRMQALFLI-UHFFFAOYSA-N
M.W :	164.20	Pubchem ID :	11629652
Synonyms :

Calculated chemistry of [ 14568-68-4 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.2
Num. rotatable bonds :	3
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	49.52
TPSA :	18.46 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.43 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.59
Log Po/w (XLOGP3) :	2.64
Log Po/w (WLOGP) :	2.24
Log Po/w (MLOGP) :	2.01
Log Po/w (SILICOS-IT) :	2.63
Consensus Log Po/w :	2.42

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.69
Solubility :	0.333 mg/ml ; 0.00203 mol/l
Class :	Soluble
Log S (Ali) :	-2.68
Solubility :	0.344 mg/ml ; 0.0021 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.09
Solubility :	0.134 mg/ml ; 0.000815 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.7

Safety of [ 14568-68-4 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 14568-68-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 14568-68-4 ]
Downstream synthetic route of [ 14568-68-4 ]

[ 14568-68-4 ] Synthesis Path-Upstream 1~1

1
[ 14568-68-4 ]
[ 1201-38-3 ]

Yield	Reaction Conditions	Operation in experiment
83%	With chromium(VI) oxide; palladium dichloride In water; acetonitrile at 20 - 60℃; for 24 h;	General procedure: To a stirred solution of olefin (0.4mmol) in CH₃CN (3.5mL) and H₂O (0.5mL) were added PdCl₂ (3.6mg, 0.02mmol, 5molpercent) and CrO₃ (20mg, 0.6mmol, 0.5equiv) at room temperature. The reaction mixture was warmed to 60°C and stirred for specified time (see Tables 5–7) in a closed flask. The reaction mixture was then filtered through a small pad of silica gel and washed with EtOAc and the filtrate concentrated. The residue in some cases contained virtually pure compound and no further purification was necessary. In other cases the residue was purified by silica gel column chromatography using petroleum ether/EtOAc as an eluent to afford the methyl ketones.

Reference： [1] Journal of Organic Chemistry, 2016, vol. 81, # 5, p. 2113 - 2121
[2] Tetrahedron, 2014, vol. 70, # 32, p. 4760 - 4767

[ 14568-68-4 ] Synthesis Path-Downstream 1~45

1
[ 641-57-6 ]
[ 14568-68-4 ]
[ 103510-88-9 ]

Yield	Reaction Conditions	Operation in experiment
	With toluene

Reference： [1]Williams et al. [Journal of Organic Chemistry, 1956, vol. 21, p. 1461]

2
1-(2,5-bis(methoxy)phenyl)ethan-1-ol [ No CAS ]
[ 14568-68-4 ]

Yield	Reaction Conditions	Operation in experiment
48%	With toluene-4-sulfonic acid In chloroform for 8h;
	With potassium hydrogensulfate

Reference： [1]Zhang, Xiang; Thimmaiah, Muralidhara; Fang, Shiyue [Synthetic Communications, 2007, vol. 37, # 11, p. 1873 - 1877]
[2]Sapewalowa; Koton [Zhurnal Obshchei Khimii, 1957, vol. 27, p. 2142,2144][J. Gen. Chem. USSR (Engl. Transl.), 1957, vol. 27, p. 2200,2202]

3
1-acetoxy-1-(2,5-dimethoxy-phenyl)-ethane [ No CAS ]
[ 14568-68-4 ]

Yield	Reaction Conditions	Operation in experiment
	at 500℃;

Reference： [1]Williams et al. [Journal of Organic Chemistry, 1956, vol. 21, p. 1461]

4
[ 14568-68-4 ]
[ 106-51-4 ]
[ 73453-74-4 ]

Yield	Reaction Conditions	Operation in experiment
37%	With trichloroacetic acid In toluene at 100℃;

Reference： [1]Manning, Wayne B.; Kelly, Terence P.; Muschik, Gary M. [Journal of Organic Chemistry, 1980, vol. 45, # 12, p. 2535 - 2536]

5
[ 155639-44-4 ]
[ 14568-68-4 ]
2-(2-fluoroethyl)-1,4-dimethoxybenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 42% 2: 45%	With tetrabutyl ammonium fluoride In tetrahydrofuran at 40℃; for 24h;
1: 36% 2: 45%	With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 8h; other temperatures, pressures and reaction times;

Reference： [1]Gerdes, John M.; Keil, Robert N.; Shulgin, Alexander T.; Mathis, Chester A. [Journal of Fluorine Chemistry, 1996, vol. 78, # 2, p. 121 - 129]
[2]Gerdes, John M.; Keil, Robert N.; Shulgin, Alexander T.; Mathis, Chester A. [Journal of Fluorine Chemistry, 1996, vol. 78, # 2, p. 121 - 129]

Yield	Reaction Conditions	Operation in experiment
	at 100℃; Polymerisation bei 100grad,110grad und 125grad;
	Polymerisation;

Yield	Reaction Conditions	Operation in experiment
	/BRN= 328617/, KHSO4, Hitze;
	RCH2Cl 3a, Ph3P, Trioxan;
	entspr. Zimtsaeure-Derivat, Cu;

8
[ 7417-19-8 ]
[ 14568-68-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 74 percent / pyridine / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) 5 deg C, 22 h 2: 45 percent / (n-Bu)4NF / tetrahydrofuran / 8 h / 20 °C / 6000480 Torr / other temperatures, pressures and reaction times

Reference： [1]Gerdes, John M.; Keil, Robert N.; Shulgin, Alexander T.; Mathis, Chester A. [Journal of Fluorine Chemistry, 1996, vol. 78, # 2, p. 121 - 129]

9
[ 52711-92-9 ]
[ 14568-68-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 74 percent / NaBH₄ / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) reflux, 2 h 2: 74 percent / pyridine / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) 5 deg C, 22 h 3: 45 percent / (n-Bu)4NF / tetrahydrofuran / 8 h / 20 °C / 6000480 Torr / other temperatures, pressures and reaction times

Reference： [1]Gerdes, John M.; Keil, Robert N.; Shulgin, Alexander T.; Mathis, Chester A. [Journal of Fluorine Chemistry, 1996, vol. 78, # 2, p. 121 - 129]

10
[ 1201-38-3 ]
[ 14568-68-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: aluminium isopropylate; isopropyl alcohol 2: KHSO₄

Reference： [1]Sapewalowa; Koton [Zhurnal Obshchei Khimii, 1957, vol. 27, p. 2142,2144][J. Gen. Chem. USSR (Engl. Transl.), 1957, vol. 27, p. 2200,2202]

11
[ 14568-68-4 ]
[ 56979-67-0 ]

Yield	Reaction Conditions	Operation in experiment
79%	Stage #1: 1,4-dimethoxy-2-vinylbenzene With sodium periodate; lithium bromide In acetic acid at 100℃; Stage #2: With potassium carbonate In methanol at 20℃; for 20h;

Reference： [1]Kostikov, Alexey P.; Malashikhina, Natalia; Popik, Vladimir V. [Journal of Organic Chemistry, 2009, vol. 74, # 4, p. 1802 - 1804]

12
[ 1779-49-3 ]
[ 93-02-7 ]
[ 14568-68-4 ]

Yield	Reaction Conditions	Operation in experiment
93%	Stage #1: Methyltriphenylphosphonium bromide With sodium amide In diethyl ether at 20℃; for 10h; Inert atmosphere; Stage #2: 2,5-dimethoxybenzaldehyde In diethyl ether at -10 - 20℃; Inert atmosphere;
93%	Stage #1: Methyltriphenylphosphonium bromide With potassium <i>tert</i>-butylate In tetrahydrofuran at 0 - 30℃; for 0.25h; Inert atmosphere; Stage #2: 2,5-dimethoxybenzaldehyde In tetrahydrofuran at 0 - 30℃; Inert atmosphere;
79%	Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 3h; Inert atmosphere; Stage #2: 2,5-dimethoxybenzaldehyde In tetrahydrofuran; hexane Reflux;

76%	With potassium carbonate In 1,4-dioxane for 16h; Reflux;
1.92 g	Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 4h; Stage #2: 2,5-dimethoxybenzaldehyde In tetrahydrofuran; hexane for 1h;	Synthesis of I ,4-dimethoxy-2-vinylbenzene. Synthesis of I ,4-dimethoxy-2-vinylbenzene. A suspension of 11.71 g of methyl triphenylphosphonium bromide in 100 mL of dry THE was treated at room temperature with 14.3 mL of n-BuLi (2.5 M solution in n-hexane). The resulting orange solution was stirred for 4 hours. Then, a solution of 5.00 g of 2,5- dimethoxybenzaldehyde in 25 mL of dry THE was added dropwise. Upon addition, a white precipitate formed. The suspension was stirred for 1 hour and concentrated in vacuo to give a viscous orange oilthat was purified by passing through a short column of Si02 (heptane) then vacuum distillation to yield1.92 g of 1,4-dimethoxy-2-vinylbenzene as a colorless liquid. 1H-NMR (300 MHz, CDCI3): 6 3.71 (s,3H), 3.73 (s, 3H), 5.19 (dd, J1=11.2 Hz, J2=1.6 Hz, IH), 5.64 (dd, Ji=17.7 Hz, J2=1.6 Hz, 1H), 6.68-6.75 (m, 2H), 6.90-6.99 (m, 2H). GC-MS: 98.0% MS (El): 164.
	Microwave irradiation; Alkaline conditions;	Styrene synthesis Method 1: Wittig Reaction under microwave conditions. General procedure: Potassium carbonate (0.10 mol) and (ethyl)triphenylphosphoniumiodide (0.016 mol) were mixed and crushed in amortar to a fine powder and transferred into a 250 mLErlenmeyer flask. Aldehyde (0.016 mol) was added to thepowdered mixture and thoroughly mixed. The Erlenmeyerflask was covered with a watch glass and placed into amicrowave oven along with a 1 L beaker of ice (to ensurethat the reaction mixture did not overheat). The microwavewas run at full power for 12 min, making sure to stop theheating and replace the ice when it had melted. A tinysample of the crude reaction product was removed, dilutedin a small amount of hexanes and analyzed by TLC to checkthe reaction progress. Upon completion, the crude solidswere extracted with hexanes (3 × 20 mL). The combinedhexane extracts were placed in a round-bottomed flask andconcentrated by rotary evaporation to obtain a yellow oilwhich was purified by flash chromatography on silica gelusing hexanes or a mixture of hexanes/ethyl acetate aseluent.
	With potassium carbonate In 1,4-dioxane for 24h; Schlenk technique; Inert atmosphere; Reflux;

Reference： [1]Location in patent: experimental part Sun, Bin; Hoshino, Juma; Jermihov, Katie; Marler, Laura; Pezzuto, John M.; Mesecar, Andrew D.; Cushman, Mark [Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 14, p. 5352 - 5366]
[2]Cong, Fei; Wei, Yongliang; Tang, Pingping [Chemical Communications, 2018, vol. 54, # 35, p. 4473 - 4476]
[3]Kostikov, Alexey P.; Malashikhina, Natalia; Popik, Vladimir V. [Journal of Organic Chemistry, 2009, vol. 74, # 4, p. 1802 - 1804]
[4]Greenhalgh, Mark D.; Thomas, Stephen P. [Journal of the American Chemical Society, 2012, vol. 134, # 29, p. 11900 - 11903]
[5]Current Patent Assignee: VERBIO VEREINIGTE BIOENERGIE AG - WO2015/155593, 2015, A1 Location in patent: Page/Page column 49
[6]Herrera-R, Angie; Castrillón, Wilson; Otero, Elver; Ruiz, Esneyder; Carda, Miguel; Agut, Raúl; Naranjo, Tonny; Moreno, Gustavo; Maldonado, Maria Elena; Cardona-G, Wilson [Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1893 - 1905]
[7]Hahm, Hyungwoo; Han, Min Su; Hong, Sukwon; Kim, Jiyun; Ryoo, Jeong Yup [Organic and Biomolecular Chemistry, 2021, vol. 19, # 28, p. 6301 - 6312]

13
[ 14568-68-4 ]
[ 540-37-4 ]
[ 23435-31-6 ]

Yield	Reaction Conditions	Operation in experiment
35%	With tetrabutylammomium bromide; potassium acetate; palladium diacetate In N,N-dimethyl-formamide at 20 - 80℃; Inert atmosphere;

14
[ 14568-68-4 ]
C₂₀H₂₄O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	With butyl phenylphosphinate; oxygen; cobalt(II) acetate; manganese(II) acetate In ethyl acetate at 90℃; for 5h;

Reference： [1]Location in patent: experimental part Liu, Kaijian; Wang, Ying; Li, Peng; Cai, Wenwen; Xiang, Jiannan [Catalysis Communications, 2012, vol. 20, p. 107 - 110]

15
[ 124-38-9 ]
[ 14568-68-4 ]
[ 83026-51-1 ]

Yield	Reaction Conditions	Operation in experiment
93%	Stage #1: 1,4-dimethoxy-2-vinylbenzene With N-(2,6-diisopropylphenyl)-N-((1E)-1-(6-[(1E)-N-(2,6-diisopropylphenyl)ethanimidoyl]pyridin-2-yl)ethylidene)amine; ethylmagnesium bromide; iron(II) chloride In tetrahydrofuran; diethyl ether at 20℃; for 2h; Inert atmosphere; Stage #2: carbon dioxide In tetrahydrofuran; diethyl ether for 0.5h; Inert atmosphere; regioselective reaction;
82%	Stage #1: 1,4-dimethoxy-2-vinylbenzene With bis(cyclopentadienyl)titanium dichloride; isopropylmagnesium chloride; lithium bromide In diethyl ether at 30℃; for 24h; Schlenk technique; Inert atmosphere; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; for 0.5h; Schlenk technique; Inert atmosphere; regioselective reaction;

Reference： [1]Greenhalgh, Mark D.; Thomas, Stephen P. [Journal of the American Chemical Society, 2012, vol. 134, # 29, p. 11900 - 11903]
[2]Shao, Peng; Wang, Sheng; Chen, Chao; Xi, Chanjuan [Organic Letters, 2016, vol. 18, # 9, p. 2050 - 2053]

16
[ 505-23-7 ]
[ 14568-68-4 ]
[ 1603829-63-5 ]

Yield	Reaction Conditions	Operation in experiment
83%	Stage #1: 1,3 dithiane With N-chloro-succinimide In 1,2-dichloro-ethane at 0℃; for 0.666667h; Stage #2: 1,4-dimethoxy-2-vinylbenzene With iron(III) chloride In 1,2-dichloro-ethane at 20℃; for 2h;

Reference： [1]Du, Wenbin; Tian, Lixia; Lai, Junshan; Huo, Xing; Xie, Xingang; She, Xuegong; Tang, Shouchu [Organic Letters, 2014, vol. 16, # 9, p. 2470 - 2473]

17
N-methyl-C-(diethoxyphosphoryl)nitrone [ No CAS ]
[ 14568-68-4 ]
diethyl 5-(2,5-dimethoxyphenyl)-2-methylisoxazolidin-3-yl-3-phosphonate [ No CAS ]
diethyl 5-(2,5-dimethoxyphenyl)-2-methylisoxazolidin-3-yl-3-phosphonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80 % de	In toluene at 70℃; for 72h; Overall yield = 95 %;	General Procedure for the Preparation of Isoxazolidines 16 and 17 General procedure: A solution of nitrone 14 (1.0 mmol) and a vinyl aryl (1.0 mmol) in toluene (2 ml) was stirred at 70°C until the disappearance (TLC) of the starting nitrone. All volatiles were removed in vacuo and the crude products were subjected to chromatography on silica gel columns with a chloroform/methanol (100:1) mixture as eluent.

Reference： [1]Grabkowska-Druzyc, Magdalena; Balzarini, Jan; Piotrowska, Dorota G. [Nucleosides, nucleotides and nucleic acids, 2013, vol. 32, # 12, p. 682 - 699]

18
[ 14568-68-4 ]
[ 1201-38-3 ]

Yield	Reaction Conditions	Operation in experiment
85%	With palladium diacetate; Dess-Martin periodane In water; acetonitrile at 50℃; Inert atmosphere;
83%	With chromium(VI) oxide; palladium dichloride In water; acetonitrile at 20 - 60℃; for 24h;	4.2 General procedure for oxidation of terminal olefins General procedure: To a stirred solution of olefin (0.4mmol) in CH3CN (3.5mL) and H2O (0.5mL) were added PdCl2 (3.6mg, 0.02mmol, 5mol%) and CrO3 (20mg, 0.6mmol, 0.5equiv) at room temperature. The reaction mixture was warmed to 60°C and stirred for specified time (see Tables 5-7) in a closed flask. The reaction mixture was then filtered through a small pad of silica gel and washed with EtOAc and the filtrate concentrated. The residue in some cases contained virtually pure compound and no further purification was necessary. In other cases the residue was purified by silica gel column chromatography using petroleum ether/EtOAc as an eluent to afford the methyl ketones.

Reference： [1]Chaudhari, Dipali A.; Fernandes, Rodney A. [Journal of Organic Chemistry, 2016, vol. 81, # 5, p. 2113 - 2121]
[2]Fernandes, Rodney A.; Bethi, Venkati [Tetrahedron, 2014, vol. 70, # 32, p. 4760 - 4767]

19
[ 16177-47-2 ]
[ 14568-68-4 ]
(1RS,5RS,7SR)-1,2,3,4,7-pentachloro-5-(2,5-dimethoxyphenyl)-7-methylbicyclo[2.2.1]hept-2-ene [ No CAS ]
(1RS,5RS,7RS)-1,2,3,4,7-pentachloro-5-(2,5-dimethoxyphenyl)-7-methylbicyclo[2.2.1]hept-2-ene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50 % de	With hydroquinone; epichlorohydrin In toluene at 120 - 130℃; for 12h; Inert atmosphere; Sealed tube; Overall yield = 87 %; Overall yield = 712 mg; diastereoselective reaction;	General procedure for the preparation of Diels-Alder 3/4 General procedure: The mixture of 1,2,3,4,5-pentachloro-5-methylcyclopenta-1,3-diene 1 (1 g, 3.96 mmol), styrene 2a (825 mg,7.92 mmol), catalytic amount of hydroquinone (3 mg), epichlorohydrin (0.01 mL) in dry toluene (1.5 mL) was heated at 120°C - 130°C in a sealed tube. After being heated for 10 h (reaction monitored by TLC), the reaction mixture was concentrated and the resulting crude residue was purified over silica gel column chromatography using hexane as eluent to afford adducts 3a and 4a (1.15 g, 83%, in 4:1 ratio) as colourless solids.

Reference： [1]Budanur, Basavaraj M.; Khan, Faiz Ahmed [Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 2531 - 2538]

20
[ 124-38-9 ]
[ 14568-68-4 ]
[ 2386-64-3 ]
2-(2,5-dimethoxyphenyl)pentanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	Stage #1: 1,4-dimethoxy-2-vinylbenzene; ethylmagnesium chloride With zirconocene dichloride In tetrahydrofuran at -78 - 20℃; for 25h; Inert atmosphere; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; regioselective reaction;

Reference： [1]Shao, Peng; Wang, Sheng; Chen, Chao; Xi, Chanjuan [Chemical Communications, 2015, vol. 51, # 30, p. 6640 - 6642]

21
[ 497-25-6 ]
[ 201230-82-2 ]
[ 14568-68-4 ]
C₁₄H₁₇NO₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With palladium(II) trifluoroacetate; 1-<bis(adamantylcarbonyloxy)iodo>benzene In toluene; acetonitrile at 60℃; for 30h; Schlenk technique;

Reference： [1]Cheng, Jiashun; Qi, Xiaoxu; Li, Ming; Chen, Pinhong; Liu, Guosheng [Journal of the American Chemical Society, 2015, vol. 137, # 7, p. 2480 - 2483]

22
[ 85-41-6 ]
[ 201230-82-2 ]
[ 14568-68-4 ]
C₁₉H₁₇NO₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With palladium(II) trifluoroacetate; [bis(acetoxy)iodo]benzene In toluene; acetonitrile at 60℃; for 26h; Schlenk technique;

Reference： [1]Cheng, Jiashun; Qi, Xiaoxu; Li, Ming; Chen, Pinhong; Liu, Guosheng [Journal of the American Chemical Society, 2015, vol. 137, # 7, p. 2480 - 2483]

23
[ 14568-68-4 ]
C₁₅H₁₉NO₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: palladium(II) trifluoroacetate; 1-<bis(adamantylcarbonyloxy)iodo>benzene / acetonitrile; toluene / 30 h / 60 °C / 760.05 Torr / Schlenk technique 2.1: 1 h / 20 °C / Schlenk technique 2.2: 3 h / 20 °C / Schlenk technique

Reference： [1]Cheng, Jiashun; Qi, Xiaoxu; Li, Ming; Chen, Pinhong; Liu, Guosheng [Journal of the American Chemical Society, 2015, vol. 137, # 7, p. 2480 - 2483]

24
[ 85-41-6 ]
[ 14568-68-4 ]
C₂₀H₁₉NO₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: palladium(II) trifluoroacetate; [bis(acetoxy)iodo]benzene / acetonitrile; toluene / 26 h / 60 °C / 760.05 Torr / Schlenk technique 2.1: 1 h / 20 °C / Schlenk technique 2.2: 3 h / 20 °C / Schlenk technique

Reference： [1]Cheng, Jiashun; Qi, Xiaoxu; Li, Ming; Chen, Pinhong; Liu, Guosheng [Journal of the American Chemical Society, 2015, vol. 137, # 7, p. 2480 - 2483]

25
[ 14568-68-4 ]
[ 39816-35-8 ]
(1S*,4RS,7S*)-(E)-7-(2,5-dimethoxyphenyl)-3,3-dimethoxy-6-(2-nitrovinyl)bicyclo[2.2.2]oct-5-en-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With [bis(acetoxy)iodo]benzene In methanol at 0 - 20℃; for 0.75h;

Reference： [1]Sharma, Shivangi; Naganaboina, Ram Tilak; Peddinti, Rama Krishna [RSC Advances, 2015, vol. 5, # 121, p. 100060 - 100069]

26
[ 14568-68-4 ]
[ 22568-51-0 ]
(1S*,4RS,7S*)-(E)-7-(2,5-dimethoxyphenyl)-3,3-dimethoxy-5-(2-nitrovinyl)bicyclo[2.2.2]oct-5-en-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	With [bis(acetoxy)iodo]benzene In methanol at 0 - 20℃; for 0.416667h;

Reference： [1]Sharma, Shivangi; Naganaboina, Ram Tilak; Peddinti, Rama Krishna [RSC Advances, 2015, vol. 5, # 121, p. 100060 - 100069]

27
[ 124-38-9 ]
[ 14568-68-4 ]
[ 73183-34-3 ]
C₁₇H₂₅BO₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
53.4%	With [1,3-bis(cyclohexyl)imidazol-2-ylidene]copper(I) chloride; sodium t-butanolate In tetrahydrofuran at 20℃; for 36h; Sealed tube; Inert atmosphere; regioselective reaction;

Reference： [1]Butcher, Trevor W.; McClain, Edward J.; Hamilton, Tyler G.; Perrone, Trina M.; Kroner, Kayla M.; Donohoe, Gregory C.; Akhmedov, Novruz G.; Petersen, Jeffrey L.; Popp, Brian V. [Organic Letters, 2016, vol. 18, # 24, p. 6428 - 6431]

28
[ 14568-68-4 ]
(E)-2,2'-(but-1-ene-1,3-diyl)bis(1,4-dimethoxybenzene) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
49%	With bromodichloromethane; sodium iodide In acetonitrile at 90℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;	Dimerization of Alkenes; General Procedure General procedure: To a 25 mL of Schlenk tube was added NaI (36 mg, 0.24 mmol, 1.2equiv) under air, then evacuated and backfilled with N 2 (3 times). Theappropriate styrene 1 (0.2 mmol, 1.0 equiv), BrCCl 2 H (65.6 mg, 0.4mmol, 2.0 equiv) and MeCN (1 mL) were added subsequently. TheSchlenk tube was then sealed with Teflon lined cap and immersedinto a preheated oil bath. After stirring for 12 h or 18 h or 24 h(Scheme 1), the reaction mixture was cooled to r.t. and the solventwas removed under vacuum. The residue was purified by flash col-umn chromatography on silica gel to afford the desired product 2.

Reference： [1]Luo, A-Yun; Bao, Yan; Cheng, Xiu-Fen; Wang, Xi-Sheng [Synthesis, 2017, vol. 49, # 17, p. 3962 - 3967]

29
[ 14568-68-4 ]
2-amino-N-(2-(2,5-dimethoxyphenyl)-2-(trifluoromethoxy)ethyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: 1-azido-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; silver fluoride; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine / acetonitrile / 4 h / 10 °C / Inert atmosphere; Glovebox; Sealed tube; Irradiation 2.1: 10% Pt/activated carbon; hydrogen / ethanol / 8 h / 25 °C 2.2: 1 h / 20 °C
	Multi-step reaction with 3 steps 1.1: 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine; 1-azido-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; silver fluoride / acetonitrile / 4 h / 20 °C / Inert atmosphere; Sealed tube; Irradiation 2.1: 10% Pt/activated carbon; hydrogen / ethanol / 8 h / 25 °C 3.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 20 °C 3.2: 20 °C

Reference： [1]Cong, Fei; Wei, Yongliang; Tang, Pingping [Chemical Communications, 2018, vol. 54, # 35, p. 4473 - 4476]
[2]Current Patent Assignee: NANKAI UNIVERSITY - CN108129348, 2018, A

30
[ 175676-42-3 ]
[ 14568-68-4 ]
2-(2-azido-1-(trifluoromethoxy)ethyl)-1,4-dimethoxybenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
35%	With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; silver fluoride; 1-azido-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine In acetonitrile at 10℃; for 4h; Inert atmosphere; Glovebox; Sealed tube; Irradiation;
35%	With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; silver fluoride; 1-azido-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine In acetonitrile at 20℃; for 4h; Inert atmosphere; Sealed tube; Irradiation;	54 Example 6 1-(2-azido-1-(trifluoromethoxy)ethyl)-2,4,6-trimethylbenzene (4a) General procedure: Under the protection of N2, Ru(bpy)3(PF6)2 (2.4 mg, 0.00300 mmol, 1.0 mol%), AgF (19.2 mg, 0.150 mmol, 50.0 mol%) was added to the sealed tube. 4,4',4"-tri-tert-butyl-2,2':6',2"-terpyridine (tbtpy, 36.0 mg, 0.0900 mmol, 30.0 mol%),1-azido-1,3 benzo[d][1,2]iodohydroxy-3(1H)-one (3) (173.4 mg, 0.600 mmol, 2.00 eq.), then acetonitrile solvent (2.40 mL) ,4-phenylstyrene (1a) (43.9 mg, 0.300 mmol, 1.00 equiv), trifluoromethyl 4-methylbenzenesulfonate (2) (169 μL, 0.9 mmol, 3.00 equiv) was added to the reaction. The resulting mixture was then allowed to stand at room temperature and stirred under irradiation with a 14 W blue LED for 4 hours.After that, the reaction mixture was concentrated in vacuo and purified by silica gel chromatography.Elution with petroleum ether / ethyl acetate 100:1 (v / v) gave the corresponding product (4a), 65.5mg.

Reference： [1]Cong, Fei; Wei, Yongliang; Tang, Pingping [Chemical Communications, 2018, vol. 54, # 35, p. 4473 - 4476]
[2]Current Patent Assignee: NANKAI UNIVERSITY - CN108129348, 2018, A Location in patent: Paragraph 0113; 0114; 0116; 0118; 0119; 0121; 0122; 0144

31
[ 14568-68-4 ]
C₁₁H₁₄F₃NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine; 1-azido-1λ³-benzo[d][1,2]iodaoxol-3(1H)-one; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; silver fluoride / acetonitrile / 4 h / 20 °C / Inert atmosphere; Sealed tube; Irradiation 2: 10% Pt/activated carbon; hydrogen / ethanol / 8 h / 25 °C

Reference： [1]Current Patent Assignee: NANKAI UNIVERSITY - CN108129348, 2018, A

32
[ 14568-68-4 ]
[ 42020-21-3 ]

Yield	Reaction Conditions	Operation in experiment
69%	Stage #1: 1,4-dimethoxy-2-vinylbenzene With N-Bromosuccinimide; water at 80℃; for 2h; Sealed tube; Green chemistry; Stage #2: With ammonium hydroxide; water; iodine at 80℃; for 1h; Sealed tube; Green chemistry;	General experimental procedure for the synthesis of aromatic amides: General procedure: A sealed tube equipped with a magnetic stirring bar was charged with styrene 1 (1.0mmol), NBS (2.0 mmol) and water (2.0mL) at room temperature. The resulting mixture was heated to 80 °C for 2h. After disappearance of the reactant (monitored by TLC), reaction mixture was cooled to room temperature. To this reaction mixture molecular iodine (2.2 mmol) and 30% aq. ammonia solution or n-butylamine (10 mmol) were added and it was heated to 80 °C for 1h. After completion of the reaction (monitored by TLC), saturated Na2S2O3 solution (10 mL) was added to the reaction mixture, and it was extracted with ethyl acetate (2×10 mL). The organic layer was washed with brine solution (10 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue obtained was purified by column chromatography on 60-120 mesh silica gel using ethyl acetate: n-hexane (1:2) as the eluent to obtain the corresponding aromatic amide 2.

Reference： [1]Sathe, Pratima A.; Karpe, Aniket S.; Parab, Aniket A.; Parade, Babasao S.; Vadagaonkar, Kamlesh S.; Chaskar, Atul C. [Tetrahedron Letters, 2018, vol. 59, # 29, p. 2820 - 2823]

33
[ 14568-68-4 ]
3-bromo-4-methyl-7-(octyloxy)-2H-chromen-2-one [ No CAS ]
3-[(E)-2-(2,5-dimethoxyphenyl)ethenyl]-4-methyl-7-(octyloxy)-2H-chromen-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
35%	With triethanolamine; palladium diacetate for 0.5h; Reflux; Microwave irradiation;	General procedure for the Mizoroki-Heck reactions General procedure: Styrene (3 mmol), 3-bromo-7-alkyloxycoumarin (4) or 2-oxo-2H-chromen-7-yl trifluoromethanesulfonate (9)(3 mmol), triethanolamine (3 mL) and Pd(OAc)2 (0.03 g)were placed in a 25 mL flat-bottomed flask equipped with amagnetic stirring bar. The mixture was stirred and heated toreflux for a period of 30 min, under microwave irradiation.The mixture was allowed to cool and then passed through apad of silica using ethyl acetate as solvent. Then the filtratewas evaporated and the crude residue was purified by preparativechromatography (silica gel, hexane/methylenechloride (1:1) mixture) affording the coupling products in35-58% yield.

Reference： [1]Herrera-R, Angie; Castrillón, Wilson; Otero, Elver; Ruiz, Esneyder; Carda, Miguel; Agut, Raúl; Naranjo, Tonny; Moreno, Gustavo; Maldonado, Maria Elena; Cardona-G, Wilson [Medicinal Chemistry Research, 2018, vol. 27, # 8, p. 1893 - 1905]

34
[ 10538-51-9 ]
[ 14568-68-4 ]

Yield	Reaction Conditions	Operation in experiment
	With ferulic acid decarboxylase from Saccharomyces cerevisae In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 18h; Enzymatic reaction;

Reference： [1]Aleku, Godwin A.; Prause, Christoph; Bradshaw-Allen, Ruth T.; Plasch, Katharina; Glueck, Silvia M.; Bailey, Samuel S.; Payne, Karl A. P.; Parker, David A.; Faber, Kurt; Leys, David [ChemCatChem, 2018, vol. 10, # 17, p. 3736 - 3745]

35
[ 75-25-2 ]
[ 14568-68-4 ]
2-(2,2-dibromocyclopropyl)-1,4-dimethoxybenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃;

Reference： [1]Brochetta, Massimo; Borsari, Tania; Gandini, Andrea; Porey, Sandip; Deb, Arghya; Casali, Emanuele; Chakraborty, Arka; Zanoni, Giuseppe; Maiti, Debabrata [Chemistry - A European Journal, 2019, vol. 25, # 3, p. 750 - 753]

36
[ 14568-68-4 ]
3-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)acrylaldehyde [ No CAS ]
(E)-3-(2,5-dimethoxyphenyl)-2-(trifluoromethyl)acrylaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 20 - 60 °C 2: ethylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice 3: silver(l) oxide; dipotassium peroxodisulfate / N,N-dimethyl-formamide / 24 h / 20 °C

37
[ 14568-68-4 ]
1,4-dimethoxy-2-(propa-1,2-dien-1-yl)benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 20 - 60 °C 2: ethylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

38
[ 423-39-2 ]
[ 14568-68-4 ]
C₁₄H₁₀F₇NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	With 1,4-diaza-bicyclo[2.2.2]octane; tert.-butylhydroperoxide; sodium azide; cobalt acetylacetonate In tetrahydrofuran; decane; hexane at 80℃; for 12h; Inert atmosphere;

Reference： [1]Chen, Yuanjin; Li, Liangkui; He, Xiao; Li, Zhiping [ACS Catalysis, 2019, vol. 9, # 10, p. 9098 - 9102]

39
[ 421-70-5 ]
[ 14568-68-4 ]
C₁₂H₁₀BrF₂NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	With 1,4-diaza-bicyclo[2.2.2]octane; tert.-butylhydroperoxide; sodium azide; cobalt acetylacetonate In tetrahydrofuran; decane; hexane at 80℃; for 12h; Inert atmosphere;

Reference： [1]Chen, Yuanjin; Li, Liangkui; He, Xiao; Li, Zhiping [ACS Catalysis, 2019, vol. 9, # 10, p. 9098 - 9102]

40
[ 14568-68-4 ]
[ 1554363-68-6 ]
[ 199620-15-0 ]
(2R,3S,4R)-2-(acetoxymethyl)-5-((E)-3-(2,5-dimethoxyphenyl)-acryloyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With bis(η3-allyl-μ-chloropalladium(II)); N-ethyl-N,N-diisopropylamine; XPhos In 1,4-dioxane at 90℃; for 16h; Sealed tube; Inert atmosphere;

Reference： [1]Darbem, Mariana P.; Esteves, Henrique A.; de Oliveira, Isadora M.; Stefani, Hélio A. [European Journal of Organic Chemistry, 2020, vol. 2020, # 32, p. 5220 - 5226]

41
[ 110-86-1 ]
[ 14568-68-4 ]
C₁₅H₁₇NO₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92 %Spectr.	With triethyl borane; sodium triethylborohydride In tetrahydrofuran at 100℃; for 12h; Inert atmosphere; regioselective reaction;

Reference： [1]Guan, Wei; Li, Runhan; Li, Xiaohong; Li, Yanfei; Wang, Ying; Xiong, Tao; Yin, Jianjun; Zhang, Ge; Zhang, Qian [Chemical Science, 2020, vol. 11, # 42, p. 11554 - 11561]

42
[ 14568-68-4 ]
(2E)-1-(4-bromophenyl)-3-(4-hydroxy-3-methoxyphenyl) prop-2-en-1-one [ No CAS ]
(E)-1-(4-((E)-2,5-dimethoxystyryl)phenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
38%	With pyrrolidine; palladium diacetate; lithium chloride In N,N-dimethyl-formamide at 170℃; for 0.0666667h; Microwave irradiation;	4.1.4. General Procedure for the Mizoroki-Heck Reactions General procedure: Styrene (0.3 mmoL), bromochalcone (0.3 mmoL, 100 mg), pyrrolidine (0.6 mmoL,50 L), Pd(OAc)2 (6 mg, 0.027 mmoL), LiCl (12 mg, 0.28 mmoL) and DMF (1 mL) wereplaced in a 10 mL flat-bottomed flask equipped with a magnetic stirring bar. The mixturewas stirred and heated to 170 C at 200Wfor a period of 4 min, under microwave irradiation.The mixture of reaction was allowed to cool, and then 100 mL of HCl 5% were added. Then,this mixture was extracted with dichloromethane, concentrated and the crude residue waspuried by column chromatography (silica gel, hexane-ethyl acetate mixture) affording thecoupling products in 35-55% yield.

Reference： [1]Cardona-G, Wilson; Hernández, Cristian; Herrera-R, Angie; Moreno, Gustavo [Molecules, 2021, vol. 26, # 9]

43
[ 124-38-9 ]
[ 14568-68-4 ]
[ 99-97-8 ]
C₂₀H₂₅NO₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With dipotassium hydrogenphosphate; 3-benzyl-2,4,5,6-tetra(9H-carbazol-9-yl)benzonitrile In N,N-dimethyl-formamide at 28 - 32℃; for 6h; Schlenk technique; Sealed tube; Irradiation; regioselective reaction;

Reference： [1]Hahm, Hyungwoo; Han, Min Su; Hong, Sukwon; Kim, Jiyun; Ryoo, Jeong Yup [Organic and Biomolecular Chemistry, 2021, vol. 19, # 28, p. 6301 - 6312]

44
[ 14568-68-4 ]
[ 99-97-8 ]
methyl 2-(2,5-dimethoxyphenyl)-4-(methyl(p-tolyl)amino)butanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 3-benzyl-2,4,5,6-tetra(9H-carbazol-9-yl)benzonitrile; dipotassium hydrogenphosphate / N,N-dimethyl-formamide / 6 h / 28 - 32 °C / Schlenk technique; Sealed tube; Irradiation 2: diethyl ether; methanol / 1 h / 0 - 20 °C

Reference： [1]Hahm, Hyungwoo; Han, Min Su; Hong, Sukwon; Kim, Jiyun; Ryoo, Jeong Yup [Organic and Biomolecular Chemistry, 2021, vol. 19, # 28, p. 6301 - 6312]

45
[ 17292-57-8 ]
[ 14568-68-4 ]
[ 100-52-7 ]
C₂₄H₂₂O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With 3-mesityl-4,5,6,7-tetrahydrobenzo[d]thiazol-3-ium perchlorate; N-ethyl-N,N-diisopropylamine In acetonitrile at 65℃; for 16h; Irradiation; regioselective reaction;

Reference： [1]Jin, Shengfei; Sui, Xianwei; Haug, Graham C.; Nguyen, Viet D.; Dang, Hang T.; Arman, Hadi D.; Larionov, Oleg V. [ACS Catalysis, 2022, vol. 12, # 1, p. 285 - 294]

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 14568-68-4 ]

Aryls

[ 612-15-7 ]

1-Methoxy-2-vinylbenzene

Similarity: 0.97

[ 150809-45-3 ]

(E)-4-(2-Methoxystyryl)phenol

Similarity: 0.91

[ 15638-10-5 ]

1-Methoxy-2-styrylbenzene

Similarity: 0.91

[ 143212-74-2 ]

2-(3-Methoxystyryl)phenol

Similarity: 0.91

[ 62895-87-8 ]

2-(2-Vinylphenoxy)ethanol

Similarity: 0.86

Alkenes

[ 612-15-7 ]

1-Methoxy-2-vinylbenzene

Similarity: 0.97

[ 150809-45-3 ]

(E)-4-(2-Methoxystyryl)phenol

Similarity: 0.91

[ 15638-10-5 ]

1-Methoxy-2-styrylbenzene

Similarity: 0.91

[ 143212-74-2 ]

2-(3-Methoxystyryl)phenol

Similarity: 0.91

[ 62895-87-8 ]

2-(2-Vinylphenoxy)ethanol

Similarity: 0.86

Ethers

[ 612-15-7 ]

1-Methoxy-2-vinylbenzene

Similarity: 0.97

[ 150809-45-3 ]

(E)-4-(2-Methoxystyryl)phenol

Similarity: 0.91

[ 15638-10-5 ]

1-Methoxy-2-styrylbenzene

Similarity: 0.91

[ 143212-74-2 ]

2-(3-Methoxystyryl)phenol

Similarity: 0.91

[ 62895-87-8 ]

2-(2-Vinylphenoxy)ethanol

Similarity: 0.86

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 14568-68-4 ] {[proInfo.proName]}

Quality Control of [ 14568-68-4 ]

Related Doc. of [ 14568-68-4 ]

Product Details of [ 14568-68-4 ]

Calculated chemistry of [ 14568-68-4 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 14568-68-4 ]

Application In Synthesis of [ 14568-68-4 ]

[ 14568-68-4 ] Synthesis Path-Upstream 1~1

[ 14568-68-4 ] Synthesis Path-Downstream 1~45

Related Functional Groups of [ 14568-68-4 ]

Aryls

Alkenes

Ethers

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 14568-68-4 ]