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[ CAS No. 1475-13-4 ]

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2D
Chemical Structure| 1475-13-4
Chemical Structure| 1475-13-4
Structure of 1475-13-4 *Storage: {[proInfo.prStorage]}

Quality Control of [ 1475-13-4 ]

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Related Doc. of [ 1475-13-4 ]

SDS

Product Details of [ 1475-13-4 ]

CAS No. :1475-13-4MDL No. :MFCD00004511
Formula :C8H8Cl2OBoiling Point :270.7°C at 760 mmHg
Linear Structure Formula :-InChI Key :KWZDYNBHZMQRLS-UHFFFAOYSA-N
M.W :191.05Pubchem ID :92889
Synonyms :

Computed Properties of [ 1475-13-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1475-13-4 ]

Signal Word:WarningClassN/A
Precautionary Statements:P280-P302+P352-P305+P351+P338-P261UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1475-13-4 ]

  • Upstream synthesis route of [ 1475-13-4 ]
  • Downstream synthetic route of [ 1475-13-4 ]

[ 1475-13-4 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 2234-16-4 ]
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YieldReaction ConditionsOperation in experiment
99% With sodium borohydrid In methanol; water Reference Example 42
To a solution of 2',4'-dichloroacetophenone (3.0 g) in methanol (15 ml) was slowly added sodium borohydride (0.33 g) under ice-cooling.
After stirring the mixture at room temperature for 30 min, water (30 ml) was added, and the mixture was extracted with ethyl acetate (30 mlx2).
The organic layer was washed with brine, dried (MgSO4), filtered and concentrated.
The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (2:1, v/v) to give 1-(2,4-dichlorophenyl)ethanol as colorless oil (3.00 g, yield 99percent).
1H-NMR (300 MHz, CDCl3) δ:1.47 (3 H, d, J = 6.2 Hz), 1.94 (1 H, d, J = 3.6 Hz), 5.25 (1 H, qd, J = 6.3, 3.9 Hz), 7.23 - 7.37 (2 H, m), 7.55 (1 H, d, J = 8.0 Hz).
Reference: [1] Patent: EP1829863, 2007, A1
[2] Patent: WO2006/57448, 2006, A1. Location in patent: Page/Page column 116-117
[3] Zhurnal Obshchei Khimii, 1952, vol. 22, p. 489; engl. Ausg. S. 551
[4] Journal of the Chemical Society, Dalton Transactions, 2001, # 20, p. 2989 - 2995
[5] Advanced Synthesis and Catalysis, 2010, vol. 352, # 10, p. 1779 - 1783
[6] Organometallics, 2013, vol. 32, # 10, p. 3083 - 3090
[7] Organometallics, 2014, vol. 33, # 4, p. 974 - 982
[8] New Journal of Chemistry, 2017, vol. 41, # 21, p. 12736 - 12745
[9] Marine Drugs, 2018, vol. 16, # 2,
[10] Dalton Transactions, 2018, vol. 47, # 26, p. 8738 - 8745
  • 2
  • [ 13692-15-4 ]
  • [ 1475-13-4 ]
Reference: [1] Synthetic Communications, 2010, vol. 40, # 14, p. 2108 - 2112
  • 3
  • [ 75-16-1 ]
  • [ 874-42-0 ]
  • [ 1475-13-4 ]
Reference: [1] European Journal of Medicinal Chemistry, 2018, vol. 159, p. 90 - 103
  • 4
  • [ 541-73-1 ]
  • [ 1475-13-4 ]
Reference: [1] Journal of the American Chemical Society, 1946, vol. 68, p. 861,863[2] Industrial and Engineering Chemistry, 1947, vol. 39, p. 1486,1487
  • 5
  • [ 555-31-7 ]
  • [ 2234-16-4 ]
  • [ 1475-13-4 ]
Reference: [1] Journal of the American Chemical Society, 1946, vol. 68, p. 861,863[2] Industrial and Engineering Chemistry, 1947, vol. 39, p. 1486,1487
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