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[ CAS No. 14769-73-4 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 14769-73-4
Chemical Structure| 14769-73-4
Structure of 14769-73-4 *Storage: {[proInfo.prStorage]}

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Product Details of [ 14769-73-4 ]

CAS No. :14769-73-4MDL No. :MFCD00792481
Formula : C11H12N2S Boiling Point : 344.4°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :204.29Pubchem ID :26879
Synonyms :

Computed Properties of [ 14769-73-4 ]

TPSA : 40.9 H-Bond Acceptor Count : 2
XLogP3 : - H-Bond Donor Count : 0
SP3 : 0.36 Rotatable Bond Count : 1

Safety of [ 14769-73-4 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P280-P305+P351+P338UN#:N/A
Hazard Statements:H302Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 14769-73-4 ]

  • Upstream synthesis route of [ 14769-73-4 ]
  • Downstream synthetic route of [ 14769-73-4 ]

[ 14769-73-4 ] Synthesis Path-Upstream   1~15

  • 1
  • [ 16595-80-5 ]
  • [ 14769-73-4 ]
Reference: [1] Organic Letters, 2011, vol. 13, # 15, p. 3794 - 3797
[2] Asian Journal of Chemistry, 2014, vol. 26, # 3, p. 634 - 640
[3] Journal of the American Chemical Society, 2018, vol. 140, # 6, p. 2062 - 2066
  • 2
  • [ 5036-02-2 ]
  • [ 14769-73-4 ]
  • [ 14769-74-5 ]
YieldReaction ConditionsOperation in experiment
39 % ee With O,O'-dibenzoyl-L-tartaric acid In dichloromethane; water at 40℃; Sonication; Irradiation We have used equal amounts for these experiments as well.4.08 g (20 mmol) (RS)-TET was dissolved in 10 ml dichloromethaneand 8 ml water at 40 °C and 2.365 g (6.6 mmol) (R,R)-DBTA in14 ml dichloromethane at 40 °C as well. When the solutions wereadded together, ultrasonic irradiation and cooling (5 °C) wasstarted straightaway.We used a Bandelin Sonopuls HD 2200 ultrasonichomogenizer equipped with MS 72 booster horn probe(diameter 2 mm, length 191 mm; shape: exponential taper; resonancefrequency of the equipment is 20 kHz). The sonotrode wasplaced at the same location during the runs: in a vertical positionwith its tip on the water–dichloromethane phase interface. Thetemperature was controlled throughout the whole experiment toavoid the warming effect of ultrasound. The duration of sonicationwas varied between 1, 5, 10, 20 and 30 min. Then we filtered thediastereomeric salt and washed with 1 ml distiled water (Fig. 2).The salt was analysed with chiral reverse-phase HPLC. We used differentultrasonic power and the real power was measured by thecalorimetric method.
Reference: [1] Tetrahedron Asymmetry, 2002, vol. 13, # 13, p. 1429 - 1434
[2] Ultrasonics Sonochemistry, 2016, vol. 32, p. 8 - 17
  • 3
  • [ 75-15-0 ]
  • [ 62779-70-8 ]
  • [ 106-93-4 ]
  • [ 14769-73-4 ]
Reference: [1] Journal of Molecular Catalysis A: Chemical, 2015, vol. 409, p. 85 - 93
  • 4
  • [ 16595-77-0 ]
  • [ 106-93-4 ]
  • [ 14769-73-4 ]
Reference: [1] Angewandte Chemie - International Edition, 2011, vol. 50, # 40, p. 9478 - 9482
[2] Chemistry - A European Journal, 2013, vol. 19, # 42, p. 14224 - 14232
  • 5
  • [ 51608-60-7 ]
  • [ 14769-73-4 ]
Reference: [1] Journal of Molecular Catalysis A: Chemical, 2015, vol. 409, p. 85 - 93
  • 6
  • [ 112790-83-7 ]
  • [ 14769-73-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 613 - 615
  • 7
  • [ 56613-81-1 ]
  • [ 14769-73-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 613 - 615
  • 8
  • [ 121673-61-8 ]
  • [ 14769-73-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 613 - 615
  • 9
  • [ 186343-35-1 ]
  • [ 14769-73-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 613 - 615
  • 10
  • [ 848186-80-1 ]
  • [ 14769-73-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 613 - 615
  • 11
  • [ 848186-81-2 ]
  • [ 14769-73-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 613 - 615
  • 12
  • [ 62779-70-8 ]
  • [ 14769-73-4 ]
Reference: [1] Angewandte Chemie - International Edition, 2011, vol. 50, # 40, p. 9478 - 9482
[2] Chemistry - A European Journal, 2013, vol. 19, # 42, p. 14224 - 14232
  • 13
  • [ 112790-85-9 ]
  • [ 14769-73-4 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 5, p. 738 - 747
  • 14
  • [ 5036-02-2 ]
  • [ 14769-73-4 ]
Reference: [1] Tetrahedron Asymmetry, 1999, vol. 10, # 7, p. 1275 - 1281
  • 15
  • [ 14769-73-4 ]
  • [ 16595-80-5 ]
YieldReaction ConditionsOperation in experiment
92.1%
Stage #1: With sodium metabisulfite; pyrographite In isopropyl alcohol for 0.5 h;
In 1000 ml four-mouth bottle into L-tetramisole 50g, inputs isopropanol 500g, heating is dissolved, add activated carbon 0.5g, sodium metabisulfite 0.75g stirring decolourizations 30 minutes, filtration, filtrate hydrogen chloride gas under stirring 9g, to pH4-5, filtering, levamisole hydrochloride dried to get 54.3g,yield 92.1percent, the target product without yellow block, long-term storage quality and stability.
Reference: [1] Patent: CN104230959, 2016, B, . Location in patent: Paragraph 0021; 0022
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