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[ CAS No. 148461-14-7 ] {[proInfo.proName]}

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Chemical Structure| 148461-14-7
Chemical Structure| 148461-14-7
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Product Details of [ 148461-14-7 ]

CAS No. :148461-14-7 MDL No. :MFCD03427599
Formula : C24H24NOP Boiling Point : -
Linear Structure Formula :(C6H5)2P(C6H4)C3H3NO(CH(CH3)2) InChI Key :OUQSAXROROGQEE-JOCHJYFZSA-N
M.W : 373.42 Pubchem ID :9807779
Synonyms :

Calculated chemistry of [ 148461-14-7 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 27
Num. arom. heavy atoms : 18
Fraction Csp3 : 0.21
Num. rotatable bonds : 5
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 120.13
TPSA : 35.18 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : Yes
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -4.67 cm/s

Lipophilicity

Log Po/w (iLOGP) : 4.0
Log Po/w (XLOGP3) : 5.51
Log Po/w (WLOGP) : 3.87
Log Po/w (MLOGP) : 5.11
Log Po/w (SILICOS-IT) : 7.04
Consensus Log Po/w : 5.1

Druglikeness

Lipinski : 1.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -5.79
Solubility : 0.000606 mg/ml ; 0.00000162 mol/l
Class : Moderately soluble
Log S (Ali) : -6.01
Solubility : 0.000367 mg/ml ; 0.000000982 mol/l
Class : Poorly soluble
Log S (SILICOS-IT) : -8.68
Solubility : 0.000000778 mg/ml ; 0.0000000021 mol/l
Class : Poorly soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 2.0
Synthetic accessibility : 4.96

Safety of [ 148461-14-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 148461-14-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 148461-14-7 ]

[ 148461-14-7 ] Synthesis Path-Downstream   1~68

  • 1
  • [ 150255-47-3 ]
  • [ 15475-27-1 ]
  • [ 148461-14-7 ]
  • 2
  • Trifluoro-methanesulfonic acid 2-((S)-4-isopropyl-4,5-dihydro-oxazol-2-yl)-phenyl ester [ No CAS ]
  • [ 15475-27-1 ]
  • [ 148461-14-7 ]
  • 3
  • [ 1079-66-9 ]
  • [ 148836-24-2 ]
  • [ 148461-14-7 ]
  • 4
  • [ 2026-48-4 ]
  • [ 34825-99-5 ]
  • [ 148461-14-7 ]
  • 5
  • [ 1079-66-9 ]
  • [ 155049-17-5 ]
  • [ 148461-14-7 ]
  • 6
  • (-)-(4S)-4,5-Dihydro-2-<2'-(diphenylphosphinyl)phenyl>-4-isopropyloxazole [ No CAS ]
  • [ 148461-14-7 ]
  • 7
  • [ 150255-47-3 ]
  • [ 829-85-6 ]
  • [ 148461-14-7 ]
  • 9
  • [ 445-29-4 ]
  • [ 148461-14-7 ]
  • 10
  • [ 88-65-3 ]
  • [ 148461-14-7 ]
  • 12
  • [ 131380-91-1 ]
  • [ 148461-14-7 ]
  • 13
  • [ 15529-49-4 ]
  • [ 148461-14-7 ]
  • RuCl2(PPh3)(C6H4(PPh2)(COCH2CH(i-Pr)N)) [ No CAS ]
  • 14
  • (1,5-cyclooctadiene)dimethylplatinum(II) [ No CAS ]
  • [ 148461-14-7 ]
  • [(4S)-2-(2-(diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline]PtMe2 [ No CAS ]
  • 15
  • (1,2,5,6-η4-cycloocta-1,5-diene)diphenylplatinum(II) [ No CAS ]
  • [ 148461-14-7 ]
  • [(4S)-2-(2-(diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline]PtPh2 [ No CAS ]
  • 16
  • [ 10025-99-7 ]
  • [ 148461-14-7 ]
  • (C6H5)2PC6H4C3NOH3CH(CH3)2PtCl2 [ No CAS ]
  • 17
  • [ 39722-81-1 ]
  • [ 148461-14-7 ]
  • [IrCl(η(2)-C2H4)((4S)-2-[2-(diphenylphosphanyl)phenyl]-isopropyl-1,3-oxazoline)] [ No CAS ]
  • 18
  • chlorobis(ethylene)rhodium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • [RhCl(η(2)-C2H4)((4S)-2-[2-(diphenylphosphanyl)phenyl]-isopropyl-1,3-oxazoline)] [ No CAS ]
  • 19
  • tris(dibenzylideneacetone)dipalladium chloroform complex [ No CAS ]
  • [ 148461-14-7 ]
  • [ 764-42-1 ]
  • (S)-[2-[2'-(diphenylphosphanyl-κP)phenyl]-4,5-dihydro-4-isopropyloxazole-κN](η(2)-fumarodinitrile)palladium(0) [ No CAS ]
  • 20
  • [In(μ-Cl)(η-2-C8H14)2]2 [ No CAS ]
  • [ 148461-14-7 ]
  • [ 603-35-0 ]
  • [Ir(μ-Cl)((4S)-2,(2-(diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)(PPh3)]2 complex [ No CAS ]
  • 21
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 74-85-1 ]
  • [ 148461-14-7 ]
  • [IrCl(η(2)-C2H4)((4S)-2-[2-(diphenylphosphanyl)phenyl]-isopropyl-1,3-oxazoline)] [ No CAS ]
  • [IrCl(η(2)-C2H4)2((4S)-2-[2-(diphenylphosphanyl)phenyl]-isopropyl-1,3-oxazoline)] [ No CAS ]
  • 22
  • ammonium hexafluorophosphate [ No CAS ]
  • di-μ-chlorobis[(η(3)-1,3-dimethylallyl)palladium(II)] [ No CAS ]
  • [ 148461-14-7 ]
  • (η(3)-1,3-dimethylallyl)((4S)-2-[2'-(diphenylphosphino)phenyl]-4-isopropyloxazoline-P,N)palladium(II) hexafluorophosphate [ No CAS ]
  • 23
  • [ 14104-20-2 ]
  • [ 12354-84-6 ]
  • [ 7732-18-5 ]
  • [ 148461-14-7 ]
  • (R(Ir))-[(η5-C5Ne5)Ir((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)(H2O)](BF4)2 [ No CAS ]
  • 24
  • silver hexafluoroantimonate [ No CAS ]
  • [ 12354-84-6 ]
  • [ 7732-18-5 ]
  • [ 148461-14-7 ]
  • (R(Ir))-[(η5-C5Ne5)Ir((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)(H2O)](SbF6)2 [ No CAS ]
  • 25
  • sodium hexafluoroantimonate [ No CAS ]
  • dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • [(η5-C5Ne5)RhCl((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)](SbF6) [ No CAS ]
  • 26
  • [ 12354-84-6 ]
  • sodium hexafluoroantimonate [ No CAS ]
  • [ 148461-14-7 ]
  • [(η5-C5Ne5)IrCl((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)](SbF6) [ No CAS ]
  • 27
  • [ 14104-20-2 ]
  • [ 12354-84-6 ]
  • [ 148461-14-7 ]
  • [ 67-64-1 ]
  • (R(Ir))-[(η5-C5Ne5)Ir((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)(acetone)](BF4)2 [ No CAS ]
  • 28
  • silver hexafluoroantimonate [ No CAS ]
  • [ 12354-84-6 ]
  • [ 148461-14-7 ]
  • [ 67-64-1 ]
  • (R(Ir))-[(η5-C5Ne5)Ir((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)(acetone)](SbF6)2 [ No CAS ]
  • 29
  • [ 95070-52-3 ]
  • [ 148461-14-7 ]
  • (η1-3,3-diphenylprop-2-enyl)((4S)-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(2-propyl)oxazole)palladium(II) chloride [ No CAS ]
  • 30
  • [ 13755-29-8 ]
  • dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • [(η5-C5Ne5)RhCl((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)](BF4) [ No CAS ]
  • 31
  • [ 13755-29-8 ]
  • [ 12354-84-6 ]
  • [ 148461-14-7 ]
  • [(η5-C5Ne5)IrCl((4S)-2-(2-diphenylphosphino)phenyl)-4-isopropyl-1,3-oxazoline)](BF4) [ No CAS ]
  • 32
  • [ 15529-49-4 ]
  • [ 7732-18-5 ]
  • [ 148461-14-7 ]
  • [RuCl2((4S)-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)(triphenylphosphine)(H2O)] [ No CAS ]
  • 33
  • [ 12128-81-3 ]
  • [ 148461-14-7 ]
  • [W(CO)3(C4(2)H8O)((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • fac-[W(CO)3(Ph2PC6H4CNOCH2CHC3H7)2] [ No CAS ]
  • fac-[W(CO)3(Ph2PC6H4CNOCH2CHC3H7)2] [ No CAS ]
  • 34
  • sodium hexaflorophosphate [ No CAS ]
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • iridium(III)bis[(4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-1,3-oxazoline] hexafluorophosphate [ No CAS ]
  • 35
  • [ 17084-13-8 ]
  • bis[dichloro(pentamethylcyclopentadienyl)ruthenium(III)] [ No CAS ]
  • [ 148461-14-7 ]
  • [ 75-05-8 ]
  • [(η5-C5Me5)Ru((4S)-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)(acetonitrile)]PF6 [ No CAS ]
  • 36
  • [ 501909-59-7 ]
  • [ 148461-14-7 ]
  • [IrBr2(η3-allyl)((4S)-2-[2-(diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole)] [ No CAS ]
  • 37
  • [ 501909-58-6 ]
  • [ 148461-14-7 ]
  • exo-[IrCl2(η3-CH2CHPh)((4S)-2-[2-(diphenylphosphino)phenyl]-4-isopropyl-4,5-dihydro-1,3-oxazole)] [ No CAS ]
  • 38
  • [ 13755-29-8 ]
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • iridium(III)bis[(4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-1,3-oxazoline] tetrafluoroborate [ No CAS ]
  • 39
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • [ 123-54-6 ]
  • chloroiridium(III)hydrido(acetylacetonato)[(4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-1,3-oxazoline] [ No CAS ]
  • 40
  • [ 16800-47-8 ]
  • [ 148461-14-7 ]
  • [ 107-05-1 ]
  • [W(CO)4((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • [W(CO)2Cl(CH2CHCH2)((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • 41
  • [ 16800-47-8 ]
  • [ 148461-14-7 ]
  • [ 107-05-1 ]
  • [W(CO)4((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • [W(CO)2Cl(CH2CHCH2)((C6H5)2PC6H4CNOCH2CHC3H7)]*CH2Cl2 [ No CAS ]
  • 42
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • [ 105-56-6 ]
  • hydridoiridium(III)(ethyl α-cyanoacetate)bis[(4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-1,3-oxazoline] chloride [ No CAS ]
  • 43
  • [ 16800-47-8 ]
  • [ 148461-14-7 ]
  • [W(CO)4((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • [W(CO)3(C4(2)H8O)((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • fac-[W(CO)3(Ph2PC6H4CNOCH2CHC3H7)2] [ No CAS ]
  • fac-[W(CO)3(Ph2PC6H4CNOCH2CHC3H7)2] [ No CAS ]
  • 44
  • [ 16800-47-8 ]
  • [ 148461-14-7 ]
  • [W(CO)3(CH3CN)((C6H5)2PC6H4CNOCH2CHC3H7)]*C4H8O [ No CAS ]
  • 45
  • [ 16800-47-8 ]
  • [ 148461-14-7 ]
  • [ 4392-24-9 ]
  • [W(CO)2Br(CH2CHCH(C6H5))((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • 46
  • [ 14040-11-0 ]
  • [ 148461-14-7 ]
  • [W(CO)4((C6H5)2PC6H4CNOCH2CHC3H7)] [ No CAS ]
  • 47
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • [ 105-34-0 ]
  • hydridoiridium(III)(methyl α-cyanoacetate)bis[(4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-1,3-oxazoline] chloride [ No CAS ]
  • 48
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • iridium(Cl)(cyclooctene)[(4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-1,3-oxazoline] [ No CAS ]
  • 49
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • iridium(III)bis[(4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-1,3-oxazoline] chloride [ No CAS ]
  • 50
  • [ 26042-63-7 ]
  • [osmium(II)dichloride(η6-p-cymene)]2 [ No CAS ]
  • [ 7732-18-5 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)Os((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)(OPOF2)][PF6] [ No CAS ]
  • 51
  • [osmium(II)dichloride(η6-p-cymene)]2 [ No CAS ]
  • [ 7732-18-5 ]
  • [ 2923-28-6 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)Os((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)(H2O)](CF3SO3)2 [ No CAS ]
  • 52
  • silver hexafluoroantimonate [ No CAS ]
  • [osmium(II)dichloride(η6-p-cymene)]2 [ No CAS ]
  • [ 7732-18-5 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)Os((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)(H2O)][SbF6]2 [ No CAS ]
  • 53
  • [ 14104-20-2 ]
  • [osmium(II)dichloride(η6-p-cymene)]2 [ No CAS ]
  • [ 7732-18-5 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)Os((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)(H2O)][BF4]2 [ No CAS ]
  • 54
  • [ 37366-09-9 ]
  • sodium hexafluoroantimonate [ No CAS ]
  • [ 148461-14-7 ]
  • [chloro((4S)-2-(2-diphenylphosphanylphenyl)-4-isopropyl-1,3-oxazoline)(benzene)ruthenium(II)] hexafluoroantimonate [ No CAS ]
  • 55
  • sodium hexafluoroantimonate [ No CAS ]
  • [RuCl2(hexamethylbenzene)]2 [ No CAS ]
  • [ 148461-14-7 ]
  • [chloro((4S)-2-(2-diphenylphosphanylphenyl)-4-isopropyl-1,3-oxazoline)(hexamethylbenzene)ruthenium(II)] hexafluoroantimonate [ No CAS ]
  • 56
  • sodium hexafluoroantimonate [ No CAS ]
  • [ 52462-29-0 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)RuCl((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)][SbF6] [ No CAS ]
  • 57
  • sodium hexafluoroantimonate [ No CAS ]
  • [osmium(II)dichloride(η6-p-cymene)]2 [ No CAS ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)OsCl((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)][SbF6] [ No CAS ]
  • 58
  • sodium hexaflorophosphate [ No CAS ]
  • [ 52462-29-0 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)RuCl((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)][PF6] [ No CAS ]
  • 59
  • [ 13755-29-8 ]
  • [ 52462-29-0 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)RuCl((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)][BF4] [ No CAS ]
  • 60
  • [ 52462-29-0 ]
  • [ 2926-30-9 ]
  • [ 148461-14-7 ]
  • [(η6-p-MeC6H4(i)Pr)RuCl((4S)-2-(2-diphenylphosphinophenyl)-4-isopropyl-1,3-oxazoline)](CF3SO3) [ No CAS ]
  • 61
  • [ 219983-27-4 ]
  • (R)-3-(1',3'-di(4''-tolyl)prop-2'-enyl)pentane-2,4-dione [ No CAS ]
  • (S)-3-(1',3'-di(4''-ethylphenyl)prop-2'-enyl)pentane-2,4-dione [ No CAS ]
  • [ 148461-14-7 ]
  • Pd(2+)*C3H3(C6H4CH3)2(1-)*(C6H5)2P(C6H4)C3H3NOCH(CH3)2=Pd(C3H3(C6H4CH3)2)(C6H5)2PC6H4C3H3NOCH(CH3)2(1+) [ No CAS ]
  • Pd(2+)*C3H3(C6H4C2H5)2(1-)*(C6H5)2P(C6H4)C3H3NOCH(CH3)2=Pd(C3H3(C6H4C2H5)2)(C6H5)2PC6H4C3H3NOCH(CH3)2(1+) [ No CAS ]
  • 62
  • [ 219983-27-4 ]
  • N-(R)-(1,3-di(4'-tolyl)prop-2-enyl)phthalimide [ No CAS ]
  • N-(S)-(1,3-di(4'-ethylphenyl)prop-2-enyl)phthalimide [ No CAS ]
  • [ 148461-14-7 ]
  • Pd(2+)*C3H3(C6H4CH3)2(1-)*(C6H5)2P(C6H4)C3H3NOCH(CH3)2=Pd(C3H3(C6H4CH3)2)(C6H5)2PC6H4C3H3NOCH(CH3)2(1+) [ No CAS ]
  • Pd(2+)*C3H3(C6H4C2H5)2(1-)*(C6H5)2P(C6H4)C3H3NOCH(CH3)2=Pd(C3H3(C6H4C2H5)2)(C6H5)2PC6H4C3H3NOCH(CH3)2(1+) [ No CAS ]
  • 63
  • {Os3Rh(μ-H)3(CO)12} [ No CAS ]
  • [ 148461-14-7 ]
  • H3Os3Ru(CO)10((S)-2-(4-isopropyl-2-oxazoline-2-yl)phenyldiphenylphosphane) [ No CAS ]
  • 64
  • H4(ruthenium)4(carbonyl)12 [ No CAS ]
  • [ 148461-14-7 ]
  • H4Ru4(CO)10((S)-2-(4-isopropyl-2-oxazoline-2-yl)phenyldiphenylphosphane) [ No CAS ]
  • 65
  • [ 150255-47-3 ]
  • [ 65567-06-8 ]
  • [ 148461-14-7 ]
  • 66
  • [ 14104-20-2 ]
  • di-μ-chlorido-bis(η3-1,3-diphenylallyl)dipalladium(II) [ No CAS ]
  • [ 148461-14-7 ]
  • C39H37NOPPd(1+)*BF4(1-) [ No CAS ]
  • 67
  • chlorobis(cyclooctene)-iridium(I) dimer [ No CAS ]
  • [ 148461-14-7 ]
  • [IrCl(η2-coe)((4S)-2-[2-(diphenylphosphanyl)phenyl]-4-isopropyl-4,5-dihydrooxazole)] [ No CAS ]
  • 68
  • [ 35138-22-8 ]
  • [ 148461-14-7 ]
  • BF4(1-)*Rh(1+)*C8H12*C24H24NOP [ No CAS ]
YieldReaction ConditionsOperation in experiment
In toluene; at 20.0℃; for 1.0h;Inert atmosphere; 10mL in a reaction tube, was added phosphine ligand R-L7 (1.9mg, 0.005mmol) and bis (1,5Cyclooctadiene) rhodium tetrafluoroborate [Rh (COD) 2] BF4 (2.1mg, 0.005mmol), through the vacuum line system, with3 times purged with nitrogen, was added freshly distilled degassed toluene (2mL), the solution was stirred for 1 hour at room temperature under reduced pressure.Removing the solvent to give a brown solid, after vacuum was 2 hours, the solvent was added 2mL of methanol, the solution was added meansZ has the formula citral (76.1mg, 0.5mmol, E / Z = 1/99, chiral rhodium complex [Rh (R-L7) (COD)] BF4 citral with molar ratio of 1/100) and iodine sodium (7.5mg, 0.05mmol) in a vial, into an autoclave,After 6 times substituted with hydrogen, so that initial hydrogen pressure of 40bar, 60 reaction was stirred for 16 hours. cool down, CAUTION gas evolution, the autoclave was opened, the vials removed, solvent drained, the conversion rate is detected NMR, gas chromatographySpectrum (column beta-DEXTM225) detection enantiomer excess value, column chromatography, to give the product. The yield was 72%R- enantiomeric excess is 78%.
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