Name: 15029-30-8|3-Oxo-3-(piperidin-1-yl)propanenitrile|95%
Brand: Ambeed
SKU: A685211
Price: 11.0 USD
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1
[ 110-89-4 ]
[ 105-56-6 ]
[ 15029-30-8 ]

Yield	Reaction Conditions	Operation in experiment
92%	In neat (no solvent) at 20℃; Inert atmosphere;	Preparation of N-substituted cyanacetamides 1 and 4 - precursors to the cyanoximes Neat ethylcyanoacetate reacts at room temperature with neat secondary amines at solvent-free conditions to form respective amides [44,45]. The general procedure involves mixing neat piperidine or morpholine with NC-CH2-C(O)OC2H5 at 1.5:1 ratio under stirring and an N2 blanket. These reactions within 24-60h at room temperature lead to prePiPCO (1) and preMCO (4) in high yields (Scheme 1). Course of both reactions was monitored by TLC watching disappearance of the cyanoacetylacetate. Since starting compounds and final cyan-acetamides do not contain chromophores, an I2-chamber was used for plates’ development. Thus, thick off-white precipitates of 1 and 4 were filtered under vacuum, washed with small portions (∼20mL) of toluene and hexane (∼25mL), and then dried in a vacuum dessicator charged with concentrated H2SO4 for several days until smell of the amine was no longer detectable. Data for 1: yield 92%, m.p. 87-90°C. The ring methylene protons in both precursors and target cyanoximes demonstrate complex non-first order 1H NMR spectra of AA′BB′ spin systems. The 1H NMR, ppm, in dmso-d6: 4.01 (singlet, 2H), ring protons - 3.41 (“triplet”, 2H), 3.28 (“tiplet”, 2H), 1.53 (multiplet, 6H). Mass-spectrometry, positive FAB (Ar): for C8H12N2O, calculated - 152.12 (found - 152.1). Data for 4: yield ∼100%, m.p. 78-81°C, Rf=0.12 in EtOAc/hexane (1:2) mobile phase. The 1H NMR, ppm, in dmso-d6: 4.03 (singet, 2H), ring protons - 3.56 (“quartet”, 4H - next to O), 3.43 (“triplet”, next to N), 3.34 (“triplet”, next to N). Mass-spectrometry, positive FAB (Ar): for C7H10N2O2, calculated - 154.07 (found - 154.08).
60%	In ethanol at 20℃;	4.7. Preparation of cyanoacetamides 7(a-q) General procedure: In a simply obtainable screw cap bottle, a mixture of ethylcyanoacetate6 (1.2 mmol) and the suitable amine (1 mmol) in EtOH (10 mL)was stirred at RT for 4-8 h. After completion as indicated by TLC, thereaction liquid was refrigerated down to 4 °C in an ice bath. In severalcases, the precipitation of amide usually took later than some minutesto hours [12]. Filtered off the formed solid, rinsed with ether numeroustimes to obtain pure 7(a-q) in corresponding yield.
37%	With sodium ethanolate In ethanol at 20℃; for 24h;	4.2. General procedure 1: synthesis of cyanoacetamides 2a-d General procedure: A mixture of a solution of sodium ethoxide (0.1 mmol) in ethanol (3 mL), ethyl cyanoacetate (10 mmol) and amine (10 mmol) was stirred at room temperature. The reaction time is 1 h for primary amines and 24 h for secondary amine 2d. The precipitate obtained was separated by filtration, washed with diethylether and recrystallised in ethanol to provide a white solid of cyanoacetamides.

	at 20℃; Inert atmosphere; neat liquid;
	at 20 - 70℃;	4.2. General procedure for the preparation of cyanoacetamide oximes (15-18)⁴⁵ General procedure: Ethyl cyano acetic ester (11.3 g, 100 mmol) and amines (morpholine, piperidine, ethyl amine) (150 mmol) were stirred at 70 °C for 6 h, then left to stir at room temperature overnight. The product precipitated, was filtered and washed with diethyl ether to give the desired 2-cyanoacetamide derivatives, which were used without further purification in the next nitrosation step. Into an ice cooled solution of 2-acetonitrile derivatives (100 mmol) and sodium hydroxide (4 g, 100 mmol) in methanol (30 mL) was introduced gaseous methyl nitrite,45 which was generated from a suspension of sodium nitrite (8.3 g) in a mixture of methanol (10 mL) and water (10 mL) by dropwise addition of a mixture of concentrated sulfuric acid (5 mL) and water (10 mL). The mixture was stirred for 2 h at room temperature and concentrated to dryness. The residue was dissolved in the least amount of water (5 mL), ice cooled, and acidified with concentrated hydrochloric acid to precipitate. In some cases precipitation occurs only by the addition of diethyl ether.
	for 0.5h; Reflux;
	at 20℃; for 50h;
	In ethanol at 20℃;

Reference： [1]Riddles, Courtney N.; Whited, Mark; Lotlikar, Shalaka R.; Still, Korey; Patrauchan, Marianna; Silchenko, Svitlana; Gerasimchuk, Nikolay [Inorganica Chimica Acta, 2014, vol. 412, p. 94 - 103]
[2]Shaik, Jeelan Basha; Yeggoni, Daniel Pushparaju; Kandrakonda, Yelamanda Rao; Penumala, Mohan; Zinka, Raveendra Babu; Kotapati, Kasi Viswanath; Darla, Mark Manidhar; Ampasala, Dinakara Rao; Subramanyam, Rajagopal; Amooru, Damu Gangaiah [Bioorganic Chemistry, 2019, vol. 88]
[3]Location in patent: experimental part Cheikh, Nawel; Bar, Nathalie; Choukchou-Braham, Nourredine; Mostefa-Kara, Bachir; Lohier, Jean-Franois; Sopkova, Jana; Villemin, Didier [Tetrahedron, 2011, vol. 67, # 8, p. 1540 - 1551]
[4]Guareschi [Atti della Accademia delle Scienze di Torino, Classe di Scienze Fisiche, Matematiche e Naturali, vol. 27, p. 225][Chemische Berichte, 25 Ref. <1892>, 326]
[5]Location in patent: scheme or table Ratcliff, Jessica; Kuduk-Jaworska, Janina; Chojnacki, Henryk; Nemykin, Victor; Gerasimchuk, Nikolay [Inorganica Chimica Acta, 2012, vol. 385, p. 1 - 11]
[6]Location in patent: experimental part Khattab, Sherine N.; Subirós-Funosas, Ramon; El-Faham, Ayman; Albericio, Fernando [Tetrahedron, 2012, vol. 68, # 14, p. 3056 - 3062]
[7]Manidhar; Rao, K. Uma Maheswara; Reddy, N. Bakthavatchala; Sundar, Ch. Syama; Reddy, C. Suresh [Journal of the Korean Chemical Society, 2012, vol. 56, # 4, p. 459 - 463]
[8]Hayotsyan, Sargis S.; Mkryan, Gevorg G.; Aghekyan, Asya A.; Melikyan, Gagik S. [Heterocyclic Communications, 2012, vol. 18, # 4, p. 189 - 192]
[9]Basha, Shaik Jeelan; Mohan, Penumala; Yeggoni, Daniel Pushparaju; Babu, Zinka Raveendra; Kumar, Palaka Bhagath; Rao, Ampasala Dinakara; Subramanyam, Rajagopal; Damu, Amooru Gangaiah [Molecular Pharmaceutics, 2018, vol. 15, # 6, p. 2206 - 2223]

2
[ 1440-60-4 ]
[ 151-50-8 ]
[ 15029-30-8 ]

Yield	Reaction Conditions	Operation in experiment
	With ethanol

Reference： [1]Speziale; Hamm [Journal of the American Chemical Society, 1956, vol. 78, p. 5580,5582]

3
[ 15029-30-8 ]
[ 598-50-5 ]
1-[2-cyano-3-(<i>N</i>'-methyl-ureido)-acryloyl]-piperidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With orthoformic acid triethyl ester

Reference： [1]Whitehead; Traverso [Journal of the American Chemical Society, 1955, vol. 77, p. 5872,5875]

4
[ 110-89-4 ]
[ 105-34-0 ]
[ 15029-30-8 ]

Yield	Reaction Conditions	Operation in experiment
75%	With potassium <i>tert</i>-butylate at 140℃; for 0.05h; microwave irradiation;
	at 100℃; for 16h;

Reference： [1]Zradni, Fatima-Zohra; Hamelin, Jack; Derdour, Aicha [Synthetic Communications, 2002, vol. 32, # 22, p. 3525 - 3531]
[2]Gazit, Aviv; Osherov, Nir; Posner, Israel; Yaish, Pnina; Poradosu, Enrique; et al. [Journal of Medicinal Chemistry, 1991, vol. 34, # 6, p. 1896 - 1907]

5
[ 2058-74-4 ]
[ 15029-30-8 ]
2-(1-methyl-2-oxoindolin-3-ylidene)-2-cyanoacetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With piperidine In isopropyl alcohol for 13h; Heating;

Reference： [1]Ukhov, S. V.; Konshin, M. E. [Chemistry of Heterocyclic Compounds, 1992, vol. 28, # 12, p. 1379 - 1381][Khimiya Geterotsiklicheskikh Soedinenii, 1992, # 12, p. 1611 - 1613]

6
[ 15029-30-8 ]
[ 611-09-6 ]
2-[5-Nitro-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-3-oxo-3-piperidin-1-yl-propionitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	With piperidine In isopropyl alcohol for 13h; Heating;

Reference： [1]Ukhov, S. V.; Konshin, M. E. [Chemistry of Heterocyclic Compounds, 1992, vol. 28, # 12, p. 1379 - 1381][Khimiya Geterotsiklicheskikh Soedinenii, 1992, # 12, p. 1611 - 1613]

7
[ 15029-30-8 ]
[ 94127-05-6 ]
[ 141811-02-1 ]
[ 141811-12-3 ]

Yield	Reaction Conditions	Operation in experiment
1: 5% 2: 95%	With sodium methylate In tetrahydrofuran at 0℃; for 0.1h;
	With sodium methylate 1) THF, 15 min, 2) THF, 0 deg C, 48h; Yield given. Multistep reaction. Yields of byproduct given;

Reference： [1]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]
[2]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]

8
[ 15029-30-8 ]
3-phenylcarbamoylazo-crotonic acid ethyl ester [ No CAS ]
[ 141811-04-3 ]

Yield	Reaction Conditions	Operation in experiment
78%	With sodium methylate In tetrahydrofuran at 0℃; for 0.1h;

Reference： [1]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]

9
[ 15029-30-8 ]
[ 23037-61-8 ]
2-[6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-2H-isoquinolin-(1Z)-ylidene]-1-piperidin-1-yl-ethanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; acetic acid In benzene at 60℃; for 0.5h;

Reference： [1]Dormidontov, M. Yu.; Syropyatov, B. Ya.; Dautova, R. Z.; Aleksandrov, B. B.; Shklyaev, V. S.; et al. [Pharmaceutical Chemistry Journal, 1990, vol. 24, # 12, p. 882 - 885][Khimiko-Farmatsevticheskii Zhurnal, 1990, vol. 24, # 12, p. 22 - 24]

10
[ 15029-30-8 ]
[ 63160-41-8 ]
[ 141811-01-0 ]
[ 141811-11-2 ]

Yield	Reaction Conditions	Operation in experiment
1: 10% 2: 89%	With sodium methylate In tetrahydrofuran at 0℃; for 0.1h;
	With sodium methylate 1) THF, 15 min, 2) THF, 0 deg C, 3h; Yield given. Multistep reaction. Yields of byproduct given;

Reference： [1]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]
[2]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]

11
[ 15029-30-8 ]
[ 63160-33-8 ]
[ 141810-99-3 ]

Yield	Reaction Conditions	Operation in experiment
79%	With sodium methylate In tetrahydrofuran at 0℃; for 0.1h;

Reference： [1]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]

12
[ 15029-30-8 ]
[ 95239-03-5 ]
[ 141811-00-9 ]

Yield	Reaction Conditions	Operation in experiment
80%	With sodium methylate In tetrahydrofuran at 0℃; for 0.1h;

Reference： [1]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]

13
[ 15029-30-8 ]
[ 94126-55-3 ]
[ 141811-03-2 ]

Yield	Reaction Conditions	Operation in experiment
90%	With sodium methylate In tetrahydrofuran at 0℃; for 0.1h;

Reference： [1]Attanasi, Orazio A.; Crescentini, Lucia De; Santeusanio, Stefania; Serra-Zanetti, Franco; McKillop, Alexander; Liao, Zhiyuan [Journal of the Chemical Society. Perkin transactions I, 1992, # 8, p. 1009 - 1014]

14
[ 15029-30-8 ]
[ 91-56-5 ]
2-(2-oxoindolin-3-ylidene)-2-cyanoacetic acid piperidide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With piperidine In isopropyl alcohol for 13h; Heating;

Reference： [1]Ukhov, S. V.; Konshin, M. E. [Chemistry of Heterocyclic Compounds, 1992, vol. 28, # 12, p. 1379 - 1381][Khimiya Geterotsiklicheskikh Soedinenii, 1992, # 12, p. 1611 - 1613]

16
[ 15029-30-8 ]
[ 87-48-9 ]
2-[5-Bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-3-oxo-3-piperidin-1-yl-propionitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With piperidine In isopropyl alcohol for 13h; Heating;

Reference： [1]Ukhov, S. V.; Konshin, M. E. [Chemistry of Heterocyclic Compounds, 1992, vol. 28, # 12, p. 1379 - 1381][Khimiya Geterotsiklicheskikh Soedinenii, 1992, # 12, p. 1611 - 1613]

17
[ 15029-30-8 ]
[ 99-61-6 ]
(E)-3-(3-Nitro-phenyl)-2-(piperidine-1-carbonyl)-acrylonitrile [ No CAS ]
3-(3-Nitro-phenyl)-2,4-bis-(piperidine-1-carbonyl)-pentanedinitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 38% 2: 16%	With piperidine In ethanol 1.) reflux, 2 h, 2.) RT, 16 h;

Reference： [1]Bloxham, Jason; Dell, Colin P. [Journal of the Chemical Society. Perkin transactions I, 1994, # 8, p. 989 - 994]

18
[ 15029-30-8 ]
[ 82-45-1 ]
[ 90904-53-3 ]

Yield	Reaction Conditions	Operation in experiment
84%	With trichlorophosphate In 1,4-dioxane at 75 - 80℃; for 4h;

Reference： [1]Tatke, D. R.; Seshadri, S. [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 12, p. 1197 - 1199]

19
[ 15029-30-8 ]
[ 117450-54-1 ]
2-Cyan-2-(3-methyl-tetrahydro-2H-1,3-thiazin-2-yliden)-essigsaeurepiperidid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
19%	With triethylamine In dichloromethane for 0.5h; Heating;

Reference： [1]Hanefeld, Wolfgang; Borho, Brigitte [Archiv der Pharmazie, 1989, vol. 322, p. 593 - 597]

20
[ 15029-30-8 ]
[ 117450-55-2 ]
(3-Benzyl-tetrahydro-2H-1,3-thiazin-2-yliden)-2-cyanessigsaeurepiperidid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
32%	With triethylamine In dichloromethane for 1h; Heating;

Reference： [1]Hanefeld, Wolfgang; Borho, Brigitte [Archiv der Pharmazie, 1989, vol. 322, p. 593 - 597]

21
[ 15029-30-8 ]
[ 117450-56-3 ]
2-Cyan-2-(3-phenyl-tetrahydro-2H-1,3-thiazin-2-yliden)-essigsaeurepiperidid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
32%	With triethylamine In dichloromethane for 2h; Heating;

Reference： [1]Hanefeld, Wolfgang; Borho, Brigitte [Archiv der Pharmazie, 1989, vol. 322, p. 593 - 597]

22
[ 15029-30-8 ]
[ 129759-97-3 ]
[ 129759-74-6 ]

Yield	Reaction Conditions	Operation in experiment
77.5%	With triethylamine In chloroform

Reference： [1]Mitsudera, Hiroyuki; Kamikado, Toshiya; Uneme, Hideki; Manabe, Yukiaki [Agricultural and Biological Chemistry, 1990, vol. 54, # 7, p. 1723 - 1730]

23
[ 15029-30-8 ]
[ 118217-81-5 ]
[ 126832-96-0 ]

Yield	Reaction Conditions	Operation in experiment
77.5%	With triethylamine In chloroform

Reference： [1]Mitsudera, Hiroyuki; Kamikado, Toshiya; Uneme, Hideki; Manabe, Yukiaki [Agricultural and Biological Chemistry, 1990, vol. 54, # 7, p. 1723 - 1730]

24
[ 15029-30-8 ]
[ 118217-83-7 ]
5-(3-Methyl-butylsulfanyl)-2-(piperidine-1-carbonyl)-[1,3]dithiane-2-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77.5%	With triethylamine In chloroform

Reference： [1]Mitsudera, Hiroyuki; Kamikado, Toshiya; Uneme, Hideki; Manabe, Yukiaki [Agricultural and Biological Chemistry, 1990, vol. 54, # 7, p. 1723 - 1730]

25
[ 15029-30-8 ]
[ 185-80-8 ]
2-Amino-3-oxo-3-piperidin-1-yl-propionamide; hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide In toluene at 0℃; for 0.166667h; Yield given;

Reference： [1]Andreae, Siegfried; Schmitz, Ernst; Wulf, Jens-Peter; Schulz, Burkhard [Liebigs Annalen der Chemie, 1992, # 3, p. 239 - 256]

26
[ 15029-30-8 ]
[ 1620-98-0 ]
[ 51866-38-7 ]

Yield	Reaction Conditions	Operation in experiment
54.3%	With piperidine In ethanol at 50 - 60℃; for 4h;

Reference： [1]Katsumi; Kondo; Fuse; Yamashita; Hidaka; Hosoe; Takeo; Yamashita; Watanabe [Chemical and Pharmaceutical Bulletin, 1986, vol. 34, # 4, p. 1619 - 1627]

27
[ 15029-30-8 ]
[ 81730-52-1 ]

Yield	Reaction Conditions	Operation in experiment
55.1%	With diphosphorus pentasulfide In 1,4-dioxane at 100℃; for 1h;
38%	With tetraphosphorus decasulfide In tetrahydrofuran at 50℃; for 0.5h;

Reference： [1]Bobylev, V. A.; Petrov, M. L.; Petrov, A. A. [Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 239 - 245][Zhurnal Organicheskoi Khimii, 1982, vol. 18, # 2, p. 274 - 281]
[2]Kosterina, M. F.; Morzherin, Yu. Yu.; Tkachev, A. V.; Rybalova, T. V.; Gatilov, Yu. V.; Bakulev, V. A. [Russian Chemical Bulletin, 2002, vol. 51, # 4, p. 653 - 658][Izvestiya Akademi Nauk, Seriya Khimicheskaya, 2002, # 4, p. 604 - 608]

28
[ 4224-87-7 ]
[ 15029-30-8 ]
5-Oxo-5-phenyl-2-(piperidine-1-carbonyl)-3-p-tolyl-pentanenitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With sodium ethanolate In ethanol Ambient temperature;

Reference： [1]Tabba, Hani D.; Yousef, Nidal M.; Al-Arab, Mohammad M. [Collection of Czechoslovak Chemical Communications, 1995, vol. 60, # 4, p. 594 - 604]

29
[ 15029-30-8 ]
[ 21551-47-3 ]
5-Oxo-2-(piperidine-1-carbonyl)-3,5-di-p-tolyl-pentanenitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With sodium ethanolate In ethanol Ambient temperature;

Reference： [1]Tabba, Hani D.; Yousef, Nidal M.; Al-Arab, Mohammad M. [Collection of Czechoslovak Chemical Communications, 1995, vol. 60, # 4, p. 594 - 604]

30
[ 15029-30-8 ]
1-(naphth-2-yl)-3-p-tolylprop-2-en-1-one [ No CAS ]
5-Naphthalen-2-yl-5-oxo-2-(piperidine-1-carbonyl)-3-p-tolyl-pentanenitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67%	With sodium ethanolate In ethanol Ambient temperature;

Reference： [1]Tabba, Hani D.; Yousef, Nidal M.; Al-Arab, Mohammad M. [Collection of Czechoslovak Chemical Communications, 1995, vol. 60, # 4, p. 594 - 604]

31
[ 15029-30-8 ]
[ 94-41-7 ]
5-Oxo-3,5-diphenyl-2-(piperidine-1-carbonyl)-pentanenitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With sodium ethanolate In ethanol Ambient temperature;

Reference： [1]Tabba, Hani D.; Yousef, Nidal M.; Al-Arab, Mohammad M. [Collection of Czechoslovak Chemical Communications, 1995, vol. 60, # 4, p. 594 - 604]

32
[ 15029-30-8 ]
3-(4-methoxyphenyl)-1-p-tolylprop-2-en-1-one [ No CAS ]
3-(4-Methoxy-phenyl)-5-oxo-2-(piperidine-1-carbonyl)-5-p-tolyl-pentanenitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With sodium ethanolate In ethanol Ambient temperature;

Reference： [1]Tabba, Hani D.; Yousef, Nidal M.; Al-Arab, Mohammad M. [Collection of Czechoslovak Chemical Communications, 1995, vol. 60, # 4, p. 594 - 604]

33
[ 15029-30-8 ]
[ 21330-56-3 ]
(1-Acridin-9-yl-5-amino-1H-[1,2,3]triazol-4-yl)-piperidin-1-yl-methanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%	With sodium methylate In methanol for 24h;

Reference： [1]Julino, Markus; Stevens, Malcolm F. G. [Journal of the Chemical Society. Perkin transactions I, 1998, # 10, p. 1677 - 1684]

34
[ 15029-30-8 ]
[ 135822-87-6 ]
[(4S,5S)-5-Furan-2-yl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-imidazol-4-yl]-piperidin-1-yl-methanone [ No CAS ]