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Chemical Structure| 150399-23-8 Chemical Structure| 150399-23-8

Structure of Pemetrexed disodium
CAS No.: 150399-23-8

Chemical Structure| 150399-23-8

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Pemetrexed disodium (LY231514 disodium) is an antifolate with the pentaglutamate form inhibiting thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT) with Kis of 1.3, 7.2, and 65 nM, respectively.

Synonyms: LY231514 disodium

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Product Details of Pemetrexed disodium

CAS No. :150399-23-8
Formula : C20H19N5Na2O6
M.W : 471.37
SMILES Code : O=C([C@H](CCC([O-])=O)NC(C1=CC=C(C=C1)CCC2=CNC(NC(N)=N3)=C2C3=O)=O)[O-].[Na+].[Na+]
Synonyms :
LY231514 disodium
InChI Key :NYDXNILOWQXUOF-GXKRWWSZSA-L
Pubchem ID :135413520

Safety of Pemetrexed disodium

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Pemetrexed disodium

DNA

Isoform Comparison

Biological Activity

Target
  • DHFR

    DHFR, Ki:7.2 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01953419 Gastric Cancer PHASE2 COMPLETED 2025-06-14 Sun Yat-sen UniversityCancer c... More >>enter, Guangzhou, Guangdong, 510060, China Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.61mL

2.12mL

1.06mL

21.21mL

4.24mL

2.12mL

References

 

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