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[ CAS No. 1516-37-6 ]

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type HazMat fee
Excepted Quantity Free
Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 83.00
Accessible (Haz class 3, 4, 5 or 8), International USD 133.00
2D
Chemical Structure| 1516-37-6
Chemical Structure| 1516-37-6
Structure of 1516-37-6 *Storage: {[proInfo.prStorage]}

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Product Details of [ 1516-37-6 ]

CAS No. :1516-37-6MDL No. :MFCD00022162
Formula : C8H10N2OS Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :182.24Pubchem ID :-
Synonyms :

Computed Properties of [ 1516-37-6 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1516-37-6 ]

Signal Word:DangerClass:6.1
Precautionary Statements:P501-P270-P264-P301+P310+P330-P405UN#:2811
Hazard Statements:H301Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1516-37-6 ]

  • Upstream synthesis route of [ 1516-37-6 ]
  • Downstream synthetic route of [ 1516-37-6 ]

[ 1516-37-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 1516-37-6 ]
  • [ 5464-79-9 ]
YieldReaction ConditionsOperation in experiment
94.08% at 40℃; for 17 h; Compound 3 (3.76 g, 0.02 mol) was dissolved in acetic acid (36 ml). To which was added lithium bromide (2.6 g, 0.03 mol) at room temperature, and bromine (1 ml, 0.02 mol) was slowly added dropwise in an ice bath, and then heated to 40° C., stirred for 17 h. The reaction system was lowered to room temperature and kept for 2 h. The reaction solution was filtered by suction and washed with acetic acid, and dried in a vacuum oven to give a white solid 4 (3.5 g, 94.08percent).
Reference: [1] Patent: US2016/102066, 2016, A1, . Location in patent: Paragraph 0021; 0025; 0027
[2] Medicinal Chemistry Research, 2012, vol. 21, # 7, p. 1136 - 1148
[3] Helvetica Chimica Acta, 1942, vol. 25, p. 515,519
[4] Yakugaku Zasshi, 1940, vol. 60, p. 462,473; dtsch. Ref. S. 184, 189[5] Chem.Abstr., 1941, p. 452
[6] Bulletin de la Societe Chimique de France, 1956, p. 684,688
[7] Heterocycles, 1980, vol. 14, # 8, p. 1145 - 1149
[8] Acta Poloniae Pharmaceutica - Drug Research, 2009, vol. 66, # 4, p. 387 - 392
[9] Patent: US2011/152246, 2011, A1, . Location in patent: Page/Page column 183
[10] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 6, p. 1351 - 1355
[11] Chemical Biology and Drug Design, 2016, p. 354 - 362
[12] Journal of Medicinal Chemistry, 2016, vol. 59, # 21, p. 9814 - 9824
  • 2
  • [ 67-66-3 ]
  • [ 7726-95-6 ]
  • [ 1516-37-6 ]
  • [ 5464-79-9 ]
Reference: [1] Helvetica Chimica Acta, 1942, vol. 25, p. 515,519
[2] Yakugaku Zasshi, 1940, vol. 60, p. 462,473; dtsch. Ref. S. 184, 189[3] Chem.Abstr., 1941, p. 452
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