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[ CAS No. 15250-41-6 ]

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Chemical Structure| 15250-41-6
Chemical Structure| 15250-41-6
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Product Details of [ 15250-41-6 ]

CAS No. :15250-41-6 MDL No. :MFCD12407161
Formula : C11H18N2O8 Boiling Point : 604.9°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :306.27 g/mol Pubchem ID :6997212
Synonyms :

Safety of [ 15250-41-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 15250-41-6 ]

  • Downstream synthetic route of [ 15250-41-6 ]

[ 15250-41-6 ] Synthesis Path-Downstream   1~17

  • 1
  • [ 15967-72-3 ]
  • [ 15250-41-6 ]
  • 2
  • nickel(II) salicylate [ No CAS ]
  • [ 15250-41-6 ]
  • Λ-(+)546-potassium S-(+)-1,2-propanediaminetriacetatoacetic acid nickelate(II) monohydtrate [ No CAS ]
  • 3
  • nickel(II) iodide [ No CAS ]
  • [ 15250-41-6 ]
  • Λ-(+)546-potassium S-(+)-1,2-propanediaminetriacetatoacetic acid nickelate(II) monohydtrate [ No CAS ]
  • 4
  • rubidium hydroxide [ No CAS ]
  • [ 15250-41-6 ]
  • [ 759403-02-6 ]
  • Λ-(-)546-rubidium[(S-(+)-1,2-propylenediaminetetraacetato)cobaltate]*H2O [ No CAS ]
  • 5
  • cesium hydroxide [ No CAS ]
  • [ 15250-41-6 ]
  • [ 759403-02-6 ]
  • Λ-(-)546-cesium[(S-(+)-1,2-propylenediaminetetraacetato)cobaltate]*H2O [ No CAS ]
  • 6
  • [ 15250-41-6 ]
  • [ 759403-02-6 ]
  • Λ-(-)546-potassium[(S-(+)-1,2-propylenediaminetetraacetato)cobaltate]*H2O [ No CAS ]
  • 7
  • europium(III) oxide [ No CAS ]
  • [ 15250-41-6 ]
  • Eu(3+)*OH(1-)*(O2CCH2)2NC3H6N(CH2CO2)2(4-)=EuOH((O2CCH2)2NC3H6N(CH2CO2)2)(2-) [ No CAS ]
  • 8
  • europium(III) oxide [ No CAS ]
  • [ 15250-41-6 ]
  • Eu(3+)*(HO2CCH2)(O2CCH2)NC3H6N(CH2CO2)2(3-)=Eu((HO2CCH2)(O2CCH2)NC3H6N(CH2CO2)2) [ No CAS ]
  • 9
  • terbium(III, IV) oxide [ No CAS ]
  • [ 15250-41-6 ]
  • Tb(3+)*OH(1-)*(O2CCH2)2NC3H6N(CH2CO2)2(4-)=TbOH((O2CCH2)2NC3H6N(CH2CO2)2)(2-) [ No CAS ]
  • 10
  • terbium(III, IV) oxide [ No CAS ]
  • [ 15250-41-6 ]
  • Tb(3+)*(HO2CCH2)(O2CCH2)NC3H6N(CH2CO2)2(3-)=Tb((HO2CCH2)(O2CCH2)NC3H6N(CH2CO2)2) [ No CAS ]
  • 11
  • [ 15250-41-6 ]
  • Cu(O2CCH(CH3)NHCH2)2C5NH3 [ No CAS ]
  • (O2CCH2)2NCH2CH(CH3)N(CH2COO)2Cu(2-) [ No CAS ]
  • 12
  • [ 15250-41-6 ]
  • Cu(O2CCH(CH3)NHCH2)2C5NH3 [ No CAS ]
  • (O2CCH2)2NCH2CH(CH3)N(CH2COO)2Cu(2-) [ No CAS ]
  • 13
  • [ 15250-41-6 ]
  • Cu(O2CC4NH7CH2)2C5NH3 [ No CAS ]
  • (O2CCH2)2NCH2CH(CH3)N(CH2COO)2Cu(2-) [ No CAS ]
  • 14
  • [ 15250-41-6 ]
  • Cu(O2CC4NH7CH2)2C5NH3 [ No CAS ]
  • (O2CCH2)2NCH2CH(CH3)N(CH2COO)2Cu(2-) [ No CAS ]
  • 15
  • [ 15250-41-6 ]
  • [ 67-63-0 ]
  • [ 1029441-46-0 ]
YieldReaction ConditionsOperation in experiment
Example 4a; Preparation of (S)-(-)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid isopropyl ester; The esterification is performed with the isolated (S)-(+)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid as follows:25.0 g of (S)-(+)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid together with 950 ml of isopropanol and 15.0 g of 95% sulfuric acid are heated under reflux for 162 h. The chilled solution is neutralized with a total of 27.5 g sodium hydrogen carbonate and evaporated to dryness under vacuum. The remaining residue is distributed between 200 ml of deionized water and 200 ml tert-butylmethylether, and the aqueous phase is extracted with 1×100 ml tert-butylmethylether. The unified organic phases are dried with sodium sulfate, filtered off, and the solvent is evaporated to dryness under vacuum (crude yield: 21.2 g).The crude product is dissolved in 300 ml of petroleum ether 40/65, stirred with 40 g of silica gel 0.06-0.2 mm for 30 min, filtered off, the residue is washed with 2×50 ml of solvent and the filtrate is evaporated to dryness under vacuum.Yield: 10.8 g of slight yellow oil (isopropyl ester)Analysis Data: Elementary analysis: C H N O C23H42N2O8 calc: 58.21 8.92 5.90 26.97 found: 58.12 9.08 5.70 Amount of rotation [alpha]D20 (c=4; methanol): -2.6 1H-NMR: 1.05 (d, 3H; -CH-CH3); 1.15-1.35 (dd, 24H; iPr-CH-(CH3)2); 2.5 (m, 1H, N-CH-CH2-); 2.85-3.15 (m, 2H; N-CH-CH2-); 3.5 (2s, 2×4H; N-CH2-CO); 5.0 (2q, 4H; iPr-CH-(CH3)2).13C-NMR: 15.44 (q; -CH2-CH3); 21.79 (q; -CH-(CH3)2); 21.85 (q; -CH-(CH3)2); 52.72 (t; N-CH2-CO); 55.88 (t; N-CH2-CO); 56.25 (d; N-CH-CH2-); 58.53 (t; CH-CH2-N); 67.77; 67.79 2×(t; COO-CH-); 170.99 (s; CO); 171.67 (s; CO).
  • 16
  • [ 64-17-5 ]
  • [ 15250-41-6 ]
  • [ 1029441-45-9 ]
YieldReaction ConditionsOperation in experiment
Example 3a; Preparation of (S)-(+)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid ethyl ester; The esterification is performed with the isolated (S)-(+)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid as follows:25.0 g of (S)-(+)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid together with 725 ml of ethanol and 15.0 g of 95% sulfuric acid are heated under reflux for 120 h. The chilled solution is neutralized with a total of 27.5 g sodium hydrogen carbonate and evaporated to dryness under vacuum. The remaining residue is distributed between 200 ml of deionized water and 200 ml tert-butylmethylether, and the aqueous phase is extracted with 2×100 ml tert-butylmethylether. The unified organic phases are dried with sodium sulfate, filtered off, and the solvent is evaporated to dryness under vacuum (crude yield: 19.7 g).The crude product is dissolved in 300 ml of petroleum ether 60/95, stirred with 40 g of silica gel 0.06-0.2 mm for 30 min, filtered off, the residue is washed with 2×50 ml of solvent and the filtrate is evaporated to dryness under vacuum.Yield: 7.1 g of colourless oil (ethyl ester)Analysis Data: Elementary analysis: C H N O C19H34N2O8 calc: 54.53 8.19 6.69 30.58 found: 54.51 8.36 6.56 Amount of rotation [alpha]D20 (c=4; methanol): +1.1 1H-NMR: 1.08 (d, 3H; -CH-CH3); 1.15-1.35 (dd, 12H; -CH2-CH3); 2.5 (m, 1H, N-CH-CH2-); 2.85-3.15 (m, 2H; N-CH-CH2-); 3.5 (s, 4H; N-CH2-CO); 3.6 (s, 4H; N-CH2-CO); 4.0-4.3 (m, 8H; COO-CH2-CH3)13C-NMR: 13.96 (q; -CH2-CH3); 14.0 (q; -CH2-CH3); 15.12 (q; -CH-CH3); 52.27 (t; N-CH2-CO); 55.28 (t; N-CH2-CO); 56.0 (d; N-CH-CH2-); 58.2 (t; CH-CH2-N); 60.08; 60.15 2×(t; COO-CH2-); 171.22 (s; CO); 171.87 (s; CO)
  • 17
  • [ 19777-66-3 ]
  • [ 79-11-8 ]
  • [ 15250-41-6 ]
YieldReaction ConditionsOperation in experiment
75% With sodium hydroxide; In water; at 25℃; for 12h;pH 8 - 9; 9.2 g of chloroacetic acid was sequentially added to the reaction flask.90m L water,3.3 g of <strong>[19777-66-3](S)-1,2-propanediamine dihydrochloride</strong> (3),A 10 m aqueous sodium hydroxide solution was added dropwise to adjust the pH to 8 to 9, and the mixture was reacted at 25 C for 12 hours.After the reaction is completed, concentrated hydrochloric acid is added dropwise to a pH of 2,Evaporate the solvent under reduced pressure.To the residue was added 100 ml of acetone and stirred.Filtered, recrystallized from water and acetone (1:1),Get 5.1g of white solid(S)-N,N,N',N'-1,2-propanediaminetetraacetic acid (4),Yield 75%,
Example 1; Preparation of (S)-(+)-1,2-diaminopropane-N,N,N',N'-tetraacetic acid; 150.0 g (1.02 Mol) of <strong>[19777-66-3](S)-(-)-1,2-diaminopropane dihydrochloride</strong> are introduced into 780.0 g of deionized water at RT, 578.4 g (6.12 Mol) of chloroacetic acid are added and 1785.0 g (14.28 Mol) of sodium hydroxide 32 percent by weight is proportioned to this solution for 45 min under cooling (at 15 C.). After the addition is completed the reaction mixture is heated to 40 C., wherein starting from 40 C., the reaction is kept exothermal and the temperature is kept under cooling at 40-45 C. After decay of the exothermal reaction stirring for 90 h at 40-45 C. is performed. The alkaline, colourless and clear liquid is narrowed down under vacuum at a bath temperature of 70 C. by approx. the 2.5-fold. The oily crystal slurry is mixed with 1.2 l of methanol, cooled down to 20 C., the salts are filtered off and the residue in the filter is washed with 2×300 ml of methanol. The unified methanolic solutions are completely evaporated in vacuum at a bath temperature of 70 C.The high-viscosity distillation residue is mixed with 300 ml of deionized water at 70 C. and cooled down to 0 C. Under cooling the pH-value is adjusted to 1,5 by adding 343.8 g of 95% sulphuric acid and after a post-reaction period the thick crystal slurry is mixed with 900 ml of deionized water.The crystal slurry is stirred over night at 0 C. with 2 l of acetone. The crystals are filtered off and washed with 2×250 ml of a mixture of water/acetone at a ratio of 1:2 and with 2×500 ml of pure acetone.The unified organic solution is completely evaporated under vacuum at a bath temperature of 70 C., the remaining viscous residue is mixed with a total of 600 ml glacial acetic acid and by adding 5 l of acetone at room temperature the product is precipitated. The suspension is cooled to 5 C., the product is filtered off, washed with 550 ml glacial acetic acid/acetone at a ratio of 1:10 and 2×500 ml acetone and dried at 20 C. under vacuum.Yield: 272.1 g
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