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[ CAS No. 1532533-75-7 ] {[proInfo.proName]}

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Chemical Structure| 1532533-75-7
Chemical Structure| 1532533-75-7
Structure of 1532533-75-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1532533-75-7 ]

CAS No. :1532533-75-7 MDL No. :
Formula : C31H26F3N5O7S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 669.63 Pubchem ID :-
Synonyms :
RP-5264 sulfate;TGR-1202 sulfate

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Application In Synthesis of [ 1532533-75-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1532533-75-7 ]

[ 1532533-75-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1532533-67-7 ]
  • [ 1532533-75-7 ]
YieldReaction ConditionsOperation in experiment
76% With sulfuric acid; In isopropyl alcohol; at 25 - 28℃; for 24h; (S)-2-(l-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l- yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one sulphate: To (S)-2-(l-(4-amino-3- (3-fluoro-4-isopropoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l-yl)ethyl)-6-fluoro-3-(3- fluorophenyl)-4H-chromen-4-one (15.0 g, 26.24 mmol) in isopropanol (600 ml) was cooled to 0C. To this Sulphuric acid (2.83 g, 28.86 mmol) was added and stirred at room temperature for 24h. The reaction mass was filtered and washed with petroleum ether and dried under vacuum. To the solid, water (150 ml) was added and stirred for 30 min. The solid was filtered, washed with petroleum ether and dried under vacuum to afford the title compound as off-white solid (13.5 g, 76%). MP: 125-127C. 'H-NMR (delta ppm, CDC13, 400 MHz): 8.11 (s, 1H), 7.85 (dd, J = 8.0,3.0 Hz, 1H), 7.51 (dd, J = 9.2,4.2 Hz, 1H), 7.45-7.31 (m, 3H), 7.29 (m, 1H), 7.15 (t, J = 8.3 Hz, 1H), 7.08 (dt, J = 8.5,2.4 Hz, 1H), 6.96 (br s, 1H), 6.88 (br s, 1H), 6.09 (q, J = 7.1 Hz, 1H), 4.676 (quintet, J = 6.1 Hz, 1H), 2.01 (d, J = 7.1Hz, 3H), 1.42 (d, 7 = 6.1 Hz, 6H). Mass : 572.2 (M+ + 1-H2S04). Enantiomeric excess: 89.6% as determined by HPLC on a chiralpak AD-H column, enriched in the fast eluting isomer (retention time = 12.08 min.)
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