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[ CAS No. 153374-33-5 ]

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Chemical Structure| 153374-33-5
Chemical Structure| 153374-33-5
Structure of 153374-33-5 * Storage: {[proInfo.prStorage]}

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Product Details of [ 153374-33-5 ]

CAS No. :153374-33-5 MDL No. :MFCD12923567
Formula : C8H8N2 Boiling Point : 254.2±13.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :132.16 g/mol Pubchem ID :20737640
Synonyms :

Safety of [ 153374-33-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 153374-33-5 ]

  • Downstream synthetic route of [ 153374-33-5 ]

[ 153374-33-5 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 153374-33-5 ]
  • C36H37Cl2N5O11S2 [ No CAS ]
  • C44H45ClN7O10S2(1+)*Cl(1-) [ No CAS ]
  • 2
  • [ 272-49-1 ]
  • [ 74-88-4 ]
  • [ 153374-33-5 ]
YieldReaction ConditionsOperation in experiment
General procedure: To a cold solution of 14a,b (2 mmol) in anhydrous toluene (30 mL), potassium t-butoxide (0.31 g, 2.72 mmol) and tris[2-(2-methoxyethoxy)ethyl]amine (TDA-1) (1 or 2 drops) were added. The reaction mixture was stirred at room temperature for 5 h and then iodomethane (0.1 mL, 2 mmol)was added. TLC analysis (dichloromethane) revealed that methylation was complete after 1 h (for compound 14c) or 24 h (for compound 14d). The solvent was evaporated under reduced pressure. The residue was treated with water, extracted with dichloromethane (3 x 20 mL), dried (Na2SO4), evaporated and purified by column chromatography using dichloromethane (for compound 14c) or dichloromethane/ethyl acetate (7/3) (for compound 14d) as eluent.
  • 3
  • [ 153374-33-5 ]
  • [ 100-97-0 ]
  • [ 860297-51-4 ]
  • 4
  • [ 272-49-1 ]
  • [ 77-78-1 ]
  • [ 153374-33-5 ]
  • 5
  • [ 153374-33-5 ]
  • [ 1128075-82-0 ]
  • 6
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  • [ 4755-77-5 ]
  • [ 1178894-74-0 ]
  • 7
  • [ 153374-33-5 ]
  • [ 598-21-0 ]
  • [ 1639457-23-0 ]
YieldReaction ConditionsOperation in experiment
General procedure: To a solution of 14a-d (2.5 mmol) in anhydrous dichloromethane (10 mL) anhydrous aluminum chloride (1.2 g, 8.8 mmol) was slowly added. The reaction mixture was stirred at room temperature (in the case of 15b) or heated under reflux for 10 min (in the case of 15a,c,d) and bromoacetyl bromide (0.2 mL, 2.5 mmol) in dichloromethane (2 mL) was added dropwise. The resulting solution was allowed to stir under reflux for 15-40 min. After cooling, water and ice were slowly added and the obtained precipitate was filtered off and purified by column chromatography using ethyl acetate (for compounds 15a, c) or dichloromethane/ethyl acetate (95/5) (for compound 15b,d) as eluent. For compounds 15b-d see supplementary material.
  • 8
  • [ 123846-65-1 ]
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  • [ 1639456-84-0 ]
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  • [ 1639456-85-1 ]
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  • [ 1639456-86-2 ]
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  • [ 1639456-90-8 ]
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  • [ 1639457-03-6 ]
  • 14
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  • [ 1639457-04-7 ]
  • 15
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  • [ 1639457-17-2 ]
  • 16
  • [ 153374-33-5 ]
  • [ 1639457-18-3 ]
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