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[ CAS No. 1539-06-6 ] {[proInfo.proName]}

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CAS No. :	1539-06-6	MDL No. :	MFCD00014703
Formula :	C₉H₈N₂O₅	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BRQIMWBIZLRLSV-UHFFFAOYSA-N
M.W :	224.17	Pubchem ID :	73758
Synonyms :

Safety of [ 1539-06-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280	UN#:	N/A
Hazard Statements:	H317	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1539-06-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1539-06-6 ]
Downstream synthetic route of [ 1539-06-6 ]

[ 1539-06-6 ] Synthesis Path-Upstream 1~3

1
[ 1539-06-6 ]
[ 619-05-6 ]

Reference： [1] Patent: DE151725, , ,
[2] Chemische Berichte, 1903, vol. 36, p. 4032

2
[ 1539-06-6 ]
[ 36692-49-6 ]

Reference： [1] Patent: DE151725, , ,

3
[ 1539-06-6 ]
[ 76918-64-4 ]

Reference： [1] Patent: DE151725, , ,

[ 1539-06-6 ] Synthesis Path-Downstream 1~19

1
[ 1539-06-6 ]
[ 76918-64-4 ]

Reference： [1]Patent: DE151725,

2
[ 1539-06-6 ]
[ 1588-83-6 ]

Yield	Reaction Conditions	Operation in experiment
90%	With sulfuric acid; at 100℃; for 0.5h;	4-acetamido-3-nitrobenzoic acid (17) (2 g, 8 mmol) was takenin a reaction flask, H2SO4 (30 mL) was added dropwise with stirring for 15 min, and the mixturewas heated for 15 min at 100 C. After the completion of the reaction, the mixture was poured intoice-cooled water and a solid residue was obtained after filtration. The crude was washed three timeswith 100 mL H2O to remove excess acid. The crude was recrystallized in EtOH, yielding (16) (90%). IR (KBr): 3479 and 3362 (NH); 1622 (C=O); 772 (NO2) cm1. 1H-NMR (400 MHz, DMSO-d6) delta ppm: 7.2(s, 1H, C6H3NO2); 7.8 (s, 1H, C6H3NO2); 7.9 (s, 2H, NH2); 8.5 (s, 1H, C6H3NO2); 12.6 (s, 1H, COOH).Calculated analysis for C7H6N2O4: C, 46.16; H, 3.32; N, 15.38. Found: C, 45.89; H, 3.11; N, 15.08.

Reference： [1]Molecules,2017,vol. 22
[2]Chemische Berichte,1903,vol. 36,p. 4032
[3]Patent: DE151725,

3
[ 1539-06-6 ]
[ 709-19-3 ]

Reference： [1]Chemische Berichte,1885,vol. 18,p. 2942

4
[ 556-08-1 ]
[ 1539-06-6 ]

Yield	Reaction Conditions	Operation in experiment
84%	With sulfuric acid; nitric acid; at 0 - 20℃; for 0.666667h;	4-acetamidobenzoic acid (24) (2.5 g, 14 mmol) was addedslowly to a mixture (1:1) of HNO3 and conc. H2SO4 (40 mL) with stirring for 10 min at 0 C. After,the mixture was stirred for 30 min at room temperature. The reaction mixture was poured into icewater and neutralized by adding 15 mL of 5% Na2CO3. The product was obtained by filtration andwashed with an excess of H2O. The crude was purified by recrystallization with ethanol, yielding (17)(84%). IR (KBr): 3324 (NH); 2912 (CH); 1717 and 1672 (C=O); 773 (NO2) cm1. 1H-NMR (400 MHz,DMSO-d6) δ ppm: 2.1 (s, 3H, CH3); 7.8 (s, 1H, C6H3NO2); 8.1 (s, 1H, C6H3NO2); 8.3 (s, 1H, C6H3NO2);10.2 (s, 1H, NH); 12.6 (s, 1H, COOH). Calculated analysis for C9H8N2O5: C, 48.22; H, 3.60; N, 12.50.Found: C, 47.90; H, 3.30; N, 12.20.

Reference： [1]Molecules,2017,vol. 22
[2]Journal of Organic Chemistry USSR (English Translation),1986,vol. 22,p. 578 - 582
Zhurnal Organicheskoi Khimii,1986,vol. 22,p. 645 - 650
[3]Journal of Medicinal Chemistry,1984,vol. 27,p. 1083 - 1089
[4]European Journal of Medicinal Chemistry,1995,vol. 30,p. 561 - 568
[5]Chemische Berichte,1885,vol. 18,p. 2942

5
[ 50342-17-1 ]
[ 1539-06-6 ]
[ 145665-74-3 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine; trichlorophosphate

Reference： [1]Mazumdar, A. K. D.; Karmakar, P. K.; Rahman, M.; Saha, G. C.; Rangachari, K.; Banerji, K. D. [Journal of the Indian Chemical Society, 1992, vol. 69, # 4, p. 207 - 209]

6
[ 699-91-2 ]
[ 1539-06-6 ]
[ 145665-72-1 ]

Reference： [1]Journal of the Indian Chemical Society,1992,vol. 69,p. 207 - 209

7
[ 1539-06-6 ]
[ 24170-23-8 ]

Yield	Reaction Conditions	Operation in experiment
	With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 1h;	Oxalyl chloride (1.25 g) was added dropwise to a solution of 1.00 g of 4-acetylamino-3-nitrobenzoic acid and 0.20 g of N,N-dimethylformamide in 15 ml of methylene chloride while being cooled with ice.. The mixture was further stirred at room temperature for 1 hour.. The reaction solution was concentrated, and diisopropyl ether was added thereto for crystallization.. The crystals were added to a solution of 0.483 g of 2-aminomethylpyridine and 0.35 g of triethylamine in 15 ml of methylene chloride.. After the mixture was stirred at room temperature for 1 hour, the organic layer was washed twice with water (100 ml*2) and then with 100 ml of a sodium hydrogencarbonate aqueous solution.. The organic layer was concentrated to give 0.99 g of N-(2-pyridylmethyl)-4-acetylamino-3-nitrobenzamide. Properties of the compound: 1H-NMR(CDCl3, δ): 2.33(3H, s), 4.76(2H, d, J=4.8 Hz), 7.25(1H, dd, J=5.0 and 7.2 Hz), 7.34(1H, d, J=7.9 Hz), 7.71(1H, dt, J=1.8 and 7.8 Hz), 7.84(1H, s), 8.14(1H, dd, J=2.1 and 8.8 Hz), 8.58(1H, d, J=4.9 Hz), 8.77(1H, d, J=2.1 Hz), 8.90(1H, d, J=8.0 Hz), 10.47(1H, s).
	With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 40℃; for 3h;	Example 1 (i) 4-Acetamido-3-nitrobenzoyl chloride (2) 4-Acetamido-3-nitrobenzoic acid 1 (Alfa Aesar, 5.6g, 25mmol), oxalyl chloride (4.76g, 38mmol), chloroform (50ml), DMF (few drops) were stirred at 40C for 3 hours. The solvent was removed in vacuo to give a yellow solid that was used in the next step without further purification.

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1986,vol. 22,p. 578 - 582
Zhurnal Organicheskoi Khimii,1986,vol. 22,p. 645 - 650
[2]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1990,vol. 29,p. 1077 - 1080
[3]Journal of Medicinal Chemistry,1984,vol. 27,p. 1083 - 1089
[4]European Journal of Medicinal Chemistry,1995,vol. 30,p. 561 - 568
[5]Patent: US6352985,2002,B1 .Location in patent: Page column 61
[6]Patent: WO2007/20400,2007,A1 .Location in patent: Page/Page column 21
[7]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 2133 - 2140

8
[ 1539-06-6 ]
[ 74-88-4 ]
[ 6313-39-9 ]

Reference： [1]Journal of Medicinal Chemistry,1995,vol. 38,p. 3217 - 3225

9
[ 1539-06-6 ]
[ 73166-06-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1212 - 1216

10
[ 1539-06-6 ]
tin [ No CAS ]
[ 84445-93-2 ]

Reference： [1]Journal of Medicinal Chemistry,1995,vol. 38,p. 3217 - 3225

11
[ 1539-06-6 ]
tin [ No CAS ]
4-(acetylamino)-3-<(2,3-dihydroxypropanoyl)amino>benzoic acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1995,vol. 38,p. 3217 - 3225

12
[ 1539-06-6 ]
tin [ No CAS ]
[ 164466-90-4 ]

Reference： [1]Journal of Medicinal Chemistry,1995,vol. 38,p. 3217 - 3225

13
[ 3144-04-5 ]
[ 1539-06-6 ]
N-(1-butanesulfonyl)-4-acetylamino-3-nitrobenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With diaza-bicyclo-undecene; 1,1'-carbonyldiimidazole; In chloroform; water; N,N-dimethyl-formamide;	A. N-(1-Butanesulfonyl)-4-acetylamino-3-nitrobenzamide N,N'-carbonyldiimidazole (9.40 g) is added to an N,N-dimethylformamide (300 ml) solution of 4-acetylamino-3-nitro-benzoic acid (10.0 g), and the solution is stirred for 1 hour at room temperature. Then, 1-butanesulfonamide (7.92 g) and diazabicycloundecene (8.83 g) are added into the solution, and the solution is stirred for 72 hours at 100 C. After chloroform and water are added into the solution and the solution is separated into layers, the residue, which is obtained by concentrating the organic layer, is purified using silica gel column chromatography (elude: ethyl acetate/methanol=4/1), and thus, N-(1-butanesulfonyl)-4-acetylamino-3-nitrobenzamide (10.75 g) is obtained. 1H-NMR (DMSO-d6, δ): 0.87 (3H, t, J=7.4 Hz), 1.37-1.44 (2H, m), 1.64-1.71 (2H, m), 2.12 (3H, s), 3.52 (2H, t, J=7.7 Hz), 7.83 (1H, d, J=8.6 Hz), 8.21 (1H, dd, J=8.6 and 2.1 Hz), 8.54 (1H, d, J=2.2 Hz), 10.56 (1H, s), 12.32 (1H, s).
	With diaza-bicyclo-undecene; 1,1'-carbonyldiimidazole;	PRODUCTION EXAMPLE 55 Production of N-(1-butanesulfonyl)-4-acetylamino-3-nitrobenzamide In the same manner as in Production Example 28, 10.75 g of N-(1-butanesulfonyl)-4-acetylamino-3-nitrobenzamide were formed from 10.0 g of 4-acetylamino-3-nitrobenzoic acid, 9.40 g of N,N'-carbonyldiimidazole, 7.92 g of 1-butanesulfonamide and 8.83 g of diazabicycloundecene. Properties of the compound: 1 H-NMR(DMSO-d6, δ): 0.87(3H, t, J=7.4 Hz), 1.37-1.44(2H, m), 1.64-1.71(2H, m), 2.12(3H, s), 3.52(2H, t, J=7.7 Hz), 7.83(1H, d, J=8.6 Hz), 8.21(1H, dd, J=8.6 and 2.1 Hz), 8.54(1H, d, J=2.2 Hz), 10.56(1H, s), 12.32(1H, s).
	With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole;	In the same manner as in Production Example 28, 10.75 g of N-(1-butanesulfonyl)-4-acetylamino-3-nitrobenzamide were formed from 10.0 g of 4-acetylamino-3-nitrobenzoic acid, 9.40 g of N,N'-carbonyldiimidazole, 7.92 g of 1-butanesulfonamide and 8.83 g of diazabicycloundecene. Properties of the compound: 1H-NMR(DMSO-d6, δ): 0.87(3H, t, J=7.4 Hz), 1.37-1.44(2H, m), 1.64-1.71(2H, m), 2.12(3H, s), 3.52(2H, t, J=7.7 Hz), 7.83(1H, d, J=8.6 Hz), 8.21(1H, dd, J=8.6 and 2.1 Hz), 8.54(1H, d, J=2.2 Hz), 10.56(1H, s), 12.32(1H, s)

Reference： [1]Patent: US6348032,2002,B1
[2]Patent: US6166219,2000,A
[3]Patent: US6352985,2002,B1 .Location in patent: Page column 149

14
[ 1634-04-4 ]
[ 1539-06-6 ]
[ 31643-09-1 ]

Yield	Reaction Conditions	Operation in experiment
	palladium; In ethanol; water;	Production of Ethyl 4-(acetylamino)-3-aminobenzoate A mixture of wet crystals of 4-(acetylamino)-3-nitrobenzoate (45.3 g, purity: 66.2%), ethanol (191.6 g), water (31.9 g), and palladium-on-carbon (palladium content: 5%, water content: 50%, 3.0 g) was stirred at 40 C. for 19 hours at a hydrogen atmosphere. The catalyst was collected by filtration and washed with a mixed solvent of water and ethanol (1/9, 30.0 g). The filtrate was concentrated, and t-butyl methyl ether (33.0 g) was added dropwise thereto at 50 C., and the mixture was cooled to 10 C. to effect crystallization. Crystals were collected and washed with t-butyl methyl ether (30.0 g), and dried at 60 C. under reduced pressure. Thus, ethyl 4-(acetylamino)-3-aminobenzoate (18.2 g) was obtained. [Physicochemical Property of the Compound] 1H-NMR(DMSO-d6, δ ppm): 1.27(3H, t), 2.05(3H, s), 4.23(2H, q), 5.19(2H, s), 7.13(1H, d, J=8.2 Hz), 7.35(1H, s), 7.47(1H, d, J=8.2 Hz), 9.19(1H, s).

Reference： [1]Patent: US6420409,2002,B1

15
3-amino-3-methyl-1-pentynyl hydrochloride [ No CAS ]
methane sulfonyl chloride [ No CAS ]
[ 1539-06-6 ]
N-(3-methylpent-1-yn-3-yl)-4-acetamido-3-nitrobenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In tetrahydrofuran; water; ethyl acetate;	EXAMPLE 8 In a 1000 mL, three-necked, round-bottomed flask fitted with a mechanical stirrer, nitrogen inlet and thermometer were placed 10 g of <strong>[1539-06-6]4-acetamido-3-nitrobenzoic acid</strong>, 200 mL of tetrahydrofuran and 31 mL of triethylamine. The resulting well-stirred mixture was cooled to -30 C. and 3.9 mL of methane sulfonyl chloride were added dropwise while keeping the reaction temperature at -30 C. The resulting suspension was stirred at -30 C. for 30 minutes, after which 6.7 g of 3-amino-3-methyl-1-pentyne hydrochloride were added slowly over a 20 minute period. After the addition was complete, the reaction mixture was stirred at -30 C. for an additional 30 minutes. The reaction mixture was then poured into a mixture of 400 mL water and 200 mL of ethyl acetate. The phases were separated and the aqueous layer was then extracted with ethyl acetate (2150 mL). The combined organic phases were washed sequentially with water (1200 mL), 5% aqueous hydrochloric acid (2200 mL), water (1200 mL), 2% aqueous sodium hydroxide (2200 mL) and water (1200 mL) and then dried over anhydrous magnesium sulfate. The solvent was removed in the rotary evaporator, yielding 8.2 g of N-(3-methylpent-1-yn-3-yl)-4-acetamido-3-nitrobenzamide. In a 500 mL, three-necked, round-bottomed flask fitted with a mechanical stirrer, a thermometer and addition funnel, the N-(3-methylpent-1-yn-3-yl)-4-acetamido-3-nitrobenzaide preapared in the preceeding step was dissolved in 180 mL of methylene chloride.

Reference： [1]Patent: US5929098,1999,A

16
[ 3731-51-9 ]
[ 79-37-8 ]
[ 1539-06-6 ]
[ 193013-63-7 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydrogencarbonate; triethylamine; In dichloromethane; di-isopropyl ether; N,N-dimethyl-formamide;	PRODUCTION EXAMPLE 23 Production of N-(2-pyridylmethyl)-4-acetylamino-3-nitrobenzamide Oxalyl chloride (1.25 g) was added dropwise to a solution of 1.00 g of 4-acetylamino-3-nitrobenzoic acid and 0.20 g of N,N-dimethylformamide in 15 ml of methylene chloride while being cooled with ice. The mixture was further stirred at room temperature for 1 hour. The reaction solution was concentrated, and diisopropyl ether was added thereto for crystallization. The crystals were added to a solution of 0.483 g of 2-aminomethylpyridine and 0.35 g of triethylamine in 15 ml of methylene chloride. After the mixture was stirred at room temperature for 1 hour, the organic layer was washed twice with water (100 ml*2) and then with 100 ml of a sodium hydrogencarbonate aqueous solution. The organic layer was concentrated to give 0.99 g of N-(2-pyridylmethyl)-4-acetylamino-3-nitrobenzamide. Properties of the compound: 1 H-NMR(CDCl3, δ): 2.33(3H, s), 4.76(2H, d, J=4.8 Hz), 7.25(1H, dd, J=5.0 and 7.2 Hz), 7.34(1H, d, J=7.9 Hz), 7.71(1H, dt, J=1.8 and 7.8 Hz), 7.84(1H, s), 8.14(1H, dd, J=2.1 and 8.8 Hz), 8.58(1H, d, J=4.9 Hz), 8.77(1H, d, J=2.1 Hz), 8.90(1H, d, J=8.0 Hz), 10.47(1H, s).

Reference： [1]Patent: US6166219,2000,A

17
[ 98-10-2 ]
[ 1539-06-6 ]
[ 193014-00-5 ]

Yield	Reaction Conditions	Operation in experiment
	With diaza-bicyclo-undecene; 1,1'-carbonyldiimidazole; In methanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;	PRODUCTION EXAMPLE 28 Production of N-benzenesulfonyl-4-acetylamino-3-nitrobenzamide N,N'-carbonyldiimidazole (14.45 g) was added to a solution of 10.00 g of 4-acetylamino-3-nitrobenzoic acid in 300 ml of N,N-dimethylformamide, and the mixture was stirred at room temperature for 1 hour. Subsequently, 14.03 g of benzenesulfonamide and 13.58 g of diazabicycloundecene were added thereto, and the mixture was stirred at 100 C. for 72 hours. The reaction mixture was separated with the addition of chloroform and water. The organic layer was then concentrated, and the resulting residue was purified through silica-gel column chromatography (eluent: a mixture of ethyl acetate and methanol at a ratio of 4:1) to give 12.67 g of N-benzenesulfonyl-4-acetylamino-3-nitrobenzamide. Properties of the compound: 1 H-NMR(DMSO-d6, δ): 2.08(3H, s), 7.39-7.47(3H, m), 7.65(1H, d, J=8.5 Hz), 7.84(2H, dd, J=1.4 and 7.7 Hz), 8.11(1H, dd, J=1.9 and 8.4 Hz), 8.38(1H, d, J=1.9 Hz), 10.34(1H, s).
		N,N'-carbonyldiimidazole (14.45 g) was added to a solution of 10.00 g of 4-acetylamino-3-nitrobenzoic acid in 300 ml of N,N-dimethylformamide, and the mixture was stirred at room temperature for 1 hour.. Subsequently, 14.03 g of benzenesulfonamide and 13.58 g of diazabicycloundecene were added thereto, and the mixture was stirred at 100 C. for 72 hours.. The reaction mixture was separated with the addition of chloroform and water.. The organic layer was then concentrated, and the resulting residue was purified through silica-gel column chromatography (eluent: a mixture of ethyl acetate and methanol at a ratio of 4:1) to give 12.67 g of N-benzenesulfonyl-4-acetylamino-3-nitrobenzamide. Properties of the compound: 1H-NMR(DMSO-d6, δ): 2.08(3H, s), 7.39-7.47(3H, m), 7.65(1H, d, J=8.5 Hz), 7.84(2H, dd, J=1.4 and 7.7 Hz), 8.11(1H, dd, J=1.9 and 8.4 Hz), 8.38(1H, d, J=1.9 Hz), 10.34(1H, s).

Reference： [1]Patent: US6166219,2000,A
[2]Patent: US6352985,2002,B1 .Location in patent: Page column 63

18
[ 110-91-8 ]
[ 1539-06-6 ]
4-acetamido-3-aminobenzoic acid morpholide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; sodium hydroxide; thionyl chloride; acetic acid; In N-methyl-acetamide; methanol; dichloromethane; water;	EXAMPLE XXXIX 11.2 G. of <strong>[1539-06-6]3-nitro-4-acetamidobenzoic acid</strong> [prepared as described in Helv. Chem. Acta 36, 806 (1953)] is suspended in 50 ml of methylene chloride and treated with 5 ml of thionyl chloride and 5 drops of dimethylformamide. The mixture is refluxed until the reaction is complete (~3 hours). The solution is cooled and treated at 10-20 C. with 18 ml of morpholine and left overnight. 25 Ml of water and 10 ml of conc. hydrochloric acid are added. The lower layer is separated and washed with water, and a 5 ml wash of methylene chloride is combined with the main solution. 50 Ml of methanol and 10 ml of 5 N sodium hydroxide solution is added at 20-25 C. After 1 hour, the mixture is neutralized with ~1 ml of acetic acid and concentrated under vacuum to a volume of ~50-60 ml. Water is added until the total volume is about ~200 ml and 2-nitro-4-morpholinocarbonylaniline filtered off and dried. The preparation of 2-acetamido-5-morpholinocarbonylaniline, an unisolated intermediate in the above procedure, is also described in Chem. Absts. 58:45416 (1963).

Reference： [1]Patent: US4139626,1979,A

19
[ 1539-06-6 ]
[ 79-22-1 ]
[ 73166-06-0 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium borohydrid; triethylamine; In tetrahydrofuran; water; ethyl acetate; acetone;	A. N-[4-(Hydroxymethyl)-2-nitrophenyl]acetamide 8.3 ml (108 mmol) methyl chloroformate dissolved in 25 ml tetrahydrofuran (THF) is added dropwise over 15 minutes to a solution of 23.9 g (107 mmol) <strong>[1539-06-6]4-(acetylamino)-3-nitrobenzoic acid</strong> and 14.8 ml (107 mmol) triethylamine in 150 ml dry THF under nitrogen and chilled in an acetone/ice bath. The temperature is kept below -5. After stirring at -5 for 30 minutes, the triethylamine.HCl is filtered off and washed with 30 ml cold THF. The combined filtrates are added dropwise to a stirred solution of 10.3 g (108 mmol) sodium borohydride in 100 ml water chilled in an acetone/ice bath. The temperature is not allowed to exceed 15. The resulting mixture is stirred at room temperature for 4 hours. After acidification with concentrated hydrochloric acid, the reaction mixture is taken up in ethyl acetate which is washed with water, 10% NaOH (X 2), water (X 2), dried (Na2 SO 4), and evaporated: 17 g. This material is crystallized from 20 ml methanol to give 9.1 g of the title compound, m.p. 114-115.

Reference： [1]Patent: US4154846,1979,A

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P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere